A5004370806- Cancer-related molecular mechanisms research
- Urologic and reproductive health conditions
- Urological Disorders and Treatments
- MicroRNA in disease regulation
- Sexual function and dysfunction studies
- RNA modifications and cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Hormonal and reproductive studies
- Genital Health and Disease
- Urinary and Genital Oncology Studies
- RNA Research and Splicing
- Sperm and Testicular Function
- Circular RNAs in diseases
- Spectroscopy Techniques in Biomedical and Chemical Research
- Prenatal Substance Exposure Effects
- HVDC Systems and Fault Protection
- Cardiovascular Disease and Adiposity
- HIV/AIDS Research and Interventions
- Menstrual Health and Disorders
- Immune Cell Function and Interaction
- Ureteral procedures and complications
- Gastric Cancer Management and Outcomes
- Advanced Optical Sensing Technologies
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
The University of Queensland
2024
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2024
First Affiliated Hospital Zhejiang University
2019-2023
Zhejiang University
2006-2021
Creative Commons
2017
Fistula Foundation
2017
National Natural Science Foundation of China
2017
Emerging discoveries of dynamic and reversible N6-methyladenosine (m6A) modification on RNA in mammals have revealed the key roles human tumorigenesis. As known m6A readers, insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) are upregulated most cancers mediates enhancement m6A-modified mRNAs stability. However, mechanisms IGF2BPs renal cell cancer (RCC) still remain unclear. Bioinformatic analysis RT-qPCR were performed to evaluate expression writer Wilms tumor 1-associating...
Downregulation of miR-502-5p has emerged as a critical factor in tumour progression several cancers. Herein, we elucidated the role bladder cancer.RT-qPCR was performed to examine expression cancer. And DNA methylation analysis showed that epigenetic mechanisms may contribute downregulation miR-502-5p. Then, wound-healing assay, transwell colony formation CCK8 assay and flow cytometry were applied evaluate function cancer cell lines. Western blot conducted measure protein levels related...
Abstract The aim of this study is to investigate the functions and mechanisms miR‐608 in prostate cancer (PCa). CISH qRT‐PCR analysis demonstrated that was low expressed PCa tissues cells, which partly attributed methylation CpG island adjacent transcription start site (TSS) gene. Intracellular overexpression inhibited vivo tumor growth, suppressed cell proliferation, G2/M transition, migration vitro, independent EMT‐associated mechanisms. Then RAC2, a GTPase previously deemed...
To investigate the effect of cocaine on apoptosis and caspase-3 activity in germ cells male rats at different ages.Cocaine hydrochloride was given (15 mg/kg body weight s.c.) to Sprague-Dawley 3 weeks (n = 8), 6 8) 12 age, daily for 28 Days. The serum levels follicle stimulating hormone (FSH), luteinizing (LH), prolactin (PRL), testosterone (T) estrogen (E2) were assayed, DNA fragmentation determined by gel eletronphoresis. cell cycle, tested flow cytometry.After 28-day treatment, testes...
Atherosclerosis (AS) is the leading cause of coronary heart disease, which primary death worldwide. Recent studies have identified disulfidptosis as a new type cell that may be involved in onset and development many diseases. However, role AS not clear. In this study, bioinformatics analysis experiments vivo vitro were performed to evaluate potential relationship between AS. AS-related sequencing data obtained from Gene Expression Omnibus (GEO). Bioinformatics techniques used differentially...
MicroRNA-155 (miR-155) is an important regulator of immune responses in humans. However, its role T-cell activation hepatitis B virus (HBV) infection remains unclear.Eighty-one patients with chronic (CHB), 77 HBV carriers, and 51 healthy controls were recruited. DNA serologic tests carried out for each subject. Levels miR-155 peripheral blood detected by quantitative reverse transcription/polymerase chain reaction. Immune T-cells was determined detection surface molecules CD38 HLA-DR using...
Although skin avulsions to male external genitalia are rare, they can be both physically and psychologically traumatic. Thus, the necessity for judicious management poses significant challenges surgeons in order avoid potential permanent disabilities. We report a case of massive penoscrotal avulsion composite graft was creatively applied cover defect which achieved good results. believe that this is great reference value fellow surgeons.A 52-year-old presented with traumatic penile scrotal...
Abstract R-loops are prevalent three-stranded nucleic acid structures, comprising a DNA-RNA hybrid and displaced single-stranded DNA, that frequently form during transcription may be attributed to genomic stability gene expression regulation. It was recently discovered RNA modification contributes maintain the of such as N6-methyladenosine (m 6 A). Yet, m A-modified in regulating remains poorly understood. Here, we demonstrated insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs)...
Currently, as obesity rates continue to rise globally, its complications are becoming increasingly detrimental public health. Beyond close association with chronic diseases such cardiovascular disease and diabetes, is also recognized an important contributor immune dysfunction. This study aims investigate how obesity-induced metabolic changes interact the response increase risk of infection inflammation. Through a systematic literature review, this paper explores affect system through...
Urethral amyloidosis is a rare condition in which eosinophilic amyloid proteins are deposited the urethra. Only small number of reports on urethral have been published. Increased interest has associated with this disease due to its clinical similarities urothelial carcinoma. A biopsy lesion and histological examination essential for correct diagnosis. Conservative management suggested by various urologists as optimal treatment approach amyloidosis; however, recurrence stricture common,...
Objective Coreceptors are important for HIV-1 entry into target cells and disease progression. The impact of highly active antiretroviral treatment (HAART) on coreceptor expression has been little studied. Methods Expression C–C chemokine receptor (CCR) 5 C–X–C (CXCR) 4 CD4+ CD8 + T was compared in HIV-1-infected individuals who had/had not received HAART, healthy controls. Relationships between coreceptors their ligands were Results This study included 23 controls 88 individuals, 35 whom...