A5102748996- Advanced NMR Techniques and Applications
- Bacteriophages and microbial interactions
- Muon and positron interactions and applications
- European history and politics
- Crystallography and Radiation Phenomena
- Parkinson's Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Communism, Protests, Social Movements
- French Historical and Cultural Studies
- Supramolecular Self-Assembly in Materials
- Monoclonal and Polyclonal Antibodies Research
- Historical Gender and Feminism Studies
- Neurological disorders and treatments
- Hydrogels: synthesis, properties, applications
- Historical Economic and Legal Thought
- Cancer Immunotherapy and Biomarkers
- Historical Studies and Socio-cultural Analysis
- Atomic and Subatomic Physics Research
- Historical Legal Studies and Society
- Historical and Literary Analyses
- Spine and Intervertebral Disc Pathology
- Historical Studies on Reproduction, Gender, Health, and Societal Changes
- Galectins and Cancer Biology
- thermodynamics and calorimetric analyses
Paul Ehrlich Institut
2024
Interuniversity Consortium for Magnetic Resonance
2020-2023
University of Florence
2020-2023
Istituto Zooprofilattico Sperimentale del Mezzogiorno
2018
Abstract Background Aggregation of α-synuclein (α-syn) is a prominent feature Parkinson’s disease (PD) and other synucleinopathies. Currently, α-syn seed amplification assays (SAAs) using cerebrospinal fluid (CSF) represent the most promising diagnostic tools for However, CSF itself contains several compounds that can modulate aggregation in patient-dependent manner, potentially undermining unoptimized SAAs preventing quantification. Methods In this study, we characterized inhibitory effect...
Recent structural studies show distinct morphologies for the fibrils of Aβ(1-42) and Aβ(1-40), which are believed not to co-fibrillize. We describe here a novel, structurally-uniform 1 : mixed fibrillar species, differs from both pure fibrils. It forms preferentially even when Aβ(1-40) peptides in non-stoichiometric ratio.
Multispecific biologics are an emerging class of drugs, in which antibodies and/or proteins designed to bind pharmacological targets covalently linked or expressed as fusion increase both therapeutic efficacy and safety. Epitope mapping on the target provides key information improve affinity also monitor manufacturing process drug stability. Solid-state NMR has been here used identify pattern residues programmed cell death ligand 1 (PD-L1) ectodomain that involved interaction with a new...
Background: The prion-like misfolding and aggregation of α-synuclein (α-syn) is involved in the pathophysiology Parkinson's disease other synucleinopathies. Seed amplification assays (SAAs) are biophysical tools that take advantage on peculiar properties prion proteins by amplifying small amounts aggregates biological fluids at expense recombinant monomeric protein added solution. SAAs have emerged as most promising for diagnosis synucleinopathies vivo. However, diagnostic outcome depends...
Today it is widely recognized that the PD-1/PD-L1 axis plays a fundamental role in escaping immune system cancers, so anti-PD-1/PD-L1 antibodies have been evaluated for their antitumor properties more than 1000 clinical trials. As result, some of them entered market revolutionizing treatment landscape specific cancer types. Nonetheless, new era based on development small molecules as anti PD-L1 drugs has begun. There are, however, limitations to advancing these compounds into stages...
Biologics are emerging as the most important class of drugs and used to treat a large variety pathologies. Most biologics proteins administered in amounts, either by intramuscular injection or intravenous infusion. Asparaginase is tetrameric protein assembly, currently against acute lymphoblastic leukemia. Here, gadolinium(III)-DOTA derivative has been conjugated asparaginase, its relaxation properties have investigated assess efficiency possible theranostic agent. The field-dependent 1H...
Cet article analyse le canon homophile du couple et de l’ami idéal dans l’Allemagne début des années 1950.Il examine tout d’abord modèle implice couple, véhiculé par les textes images principales revues homophiles la période. Ce modèle, centré sur principes réserve respectabilité, est ensuite considéré à lumière d’un vaste échantillon petites annonces publiées durant mêmes années. Il apparaît finalement que culturel répond exigences relationnelles multiples diversifiées,en leur fournissant...
Biocompatible hydrogels for tissue regeneration/replacement and drug release with specific architectures can be obtained by three-dimensional bioprinting techniques. The preservation of the higher order structure proteins embedded in as drugs or modulators is critical their biological activity. Solution nuclear magnetic resonance (NMR) experiments are currently used to investigate biotherapeutics comparability, similarity, stability studies. However, size pores gel, protein–matrix...
Magnetic resonance imaging (MRI) often requires contrast agents to improve the visualization in some tissues and organs, including gastrointestinal tract. In this latter case, instead of intravascular administration, oral can be used. Natural agents, such as fruit juice, have advantages better taste, tolerability, lower price with respect artificial agents. We characterized relaxometry profiles pineapple juice order understand origin increase relaxation rates (and thus MRI contrast)...
Several fruit juices are used as oral contrast agents to improve the quality of images in magnetic resonance cholangiopancreatography. They often preferred conventional synthetic because their very low cost, natural origin, intrinsic safety, and comparable image qualities. Pineapple blueberry most employed clinical practice due higher content manganese(II) ions. The interest pharmaceutical companies these products is testified by appearance market juice derivatives with improved efficacy....
You have accessJournal of UrologySexual Function/Dysfunction: Evaluation II (PD32)1 May 2024PD32-07 LIMITATIONS OF IIEF-15 IN THE PREOPERATIVE ASSESSMENT PATIENTS UNDERGOING SURGERY FOR PROSTATE DISEASE Giuseppe Maiolino, Francesca Mucciardi, Domenico Rizzo, Raffaele La Mura, Miriam Russo, Alessio Paladini, Ettore Mearini, and Giovanni Cochetti MaiolinoGiuseppe Maiolino , MucciardiFrancesca Mucciardi RizzoDomenico Rizzo MuraRaffaele Mura RussoMiriam Russo PaladiniAlessio Paladini...
Several protein-drug conjugates are currently being used in cancer therapy. These rely on cytotoxic organic compounds that covalently attached to the carrier proteins or interact with them via non-covalent interactions. Human transthyretin (TTR), a physiological protein, has already been identified as possible protein for delivery of drugs. Here we show structure-guided development new stable molecule based known strong binder TTR and well-established anticancer drug. This example is...
Targeting immune checkpoints is a well-established strategy in cancer therapy, and antibodies blocking PD-1/PD-L1 interactions to restore the immunological activity against cells have been clinically validated. High-affinity mutants of PD-1 ectodomain recently proposed as an alternative target PD-L1 on cells, shedding new light this research area. In dynamic scenario, mutant, here reported, largely expands chemical space nonantibody nonsmall-molecule inhibitor therapeutics that can be used...
The regulations over civil marriage in post-unification Italy envisioned the possibility of annulling a union for reasons sexual impotence one spouses. This article examines series judicial proceedings annulment on grounds male and, particular, medical -legal expertise that was adduced course case. incapacity husband and its consequences reveal how body conceptualized through dense nexus between subjectivity, family ties, social norms. In addition, difficulties inherent medial trial raise...
Abstract Several protein‐drug conjugates are currently being used in cancer therapy. These rely on cytotoxic organic compounds that covalently attached to the carrier proteins or interact with them via non‐covalent interactions. Human transthyretin (TTR), a physiological protein, has already been identified as possible protein for delivery of drugs. Here we show structure‐guided development new stable molecule based known strong binder TTR and well‐established anticancer drug. This example...