A5004580681- Ion Channels and Receptors
- Plant Stress Responses and Tolerance
- Ion channel regulation and function
- Mass Spectrometry Techniques and Applications
- Photochromic and Fluorescence Chemistry
- Postharvest Quality and Shelf Life Management
- Semiconductor materials and devices
- Spacecraft and Cryogenic Technologies
- Neurobiology and Insect Physiology Research
- Particle accelerators and beam dynamics
- Semiconductor materials and interfaces
Max Planck Institute of Molecular Physiology
2018-2024
Canonical transient receptor channels (TRPC) are non-selective cation channels. They involved in receptor-operated Ca2+ signaling and have been proposed to act as store-operated (SOC). Their malfunction is related cardiomyopathies their modulation by small molecules has shown be effective against renal cancer cells. The molecular mechanism underlying the complex activation regulation poorly understood. Here, we report electron cryo-microscopy structure of zebrafish TRPC4 its unliganded...
Canonical transient receptor potential channels (TRPC) are involved in receptor-operated and/or store-operated Ca2+ signaling. Inhibition of TRPCs by small molecules was shown to be promising treating renal diseases. In cells, the regulated calmodulin (CaM). Molecular details both CaM and drug binding have remained elusive so far. Here, we report structures TRPC4 complex with three pyridazinone-based inhibitors CaM. The reveal that all bind same cavity voltage-sensing-like domain allow us...
ABSTRACT Directly probing the endogenous biological roles of target proteins with high spatial and temporal resolution, as non-invasively reproducibly possible, is a shared conceptual goal for research across many fields, well targeted therapies. Here we describe rational design test-case practical implementation photopharmacological paradigm to empower high-performance photomodulation studies in vivo . TRPC4/5 ion channels are involved spatiotemporally resolved circuits, from pain anxiety,...
ABSTRACT Canonical transient receptor channels (TRPC) are non-selective cation channels. They involved in receptor-operated Ca 2+ signaling and have been proposed to act as store-operated (SOC). Their malfunction is related cardiomyopathies their modulation by small molecules has shown be effective against renal cancer cells. The molecular mechanism underlying the complex activation regulation poorly understood. Here, we report electron cryo-microscopy structure of zebrafish TRPC4 its...
ABSTRACT Canonical transient receptor potential channels (TRPC) are involved in receptor-operated and/or store-operated Ca 2+ signaling. Inhibition of TRPCs by small molecules was shown to be promising treating renal diseases. In cells, the regulated calmodulin. Molecular details both calmodulin and drug binding have remained elusive so far. Here we report structures TRPC4 complex with a pyridazinone-based inhibitor activator The reveal that bind same cavity voltage-sensing-like domain allow...
Canonical transient receptor channels (TRPC) are non-selective cation channels. They involved in receptor-operated Ca2+ signaling and have been proposed to act as store-operated (SOC). Their malfunction is related cardiomyopathies their modulation by small molecules has shown be effective against renal cancer cells. The molecular mechanism underlying the complex activation regulation poorly understood. Here, we report electron cryo-microscopy structure of zebrafish TRPC4 its unliganded...