A5081906623- Electron Spin Resonance Studies
- Boron and Carbon Nanomaterials Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Analytical Chemistry and Chromatography
- Fullerene Chemistry and Applications
- Insect and Pesticide Research
- Ion Channels and Receptors
- Metal and Thin Film Mechanics
- Free Radicals and Antioxidants
- Photochromic and Fluorescence Chemistry
- X-ray Diffraction in Crystallography
- Neurobiology and Insect Physiology Research
- Crystallization and Solubility Studies
- Structural and Chemical Analysis of Organic and Inorganic Compounds
University of Leeds
2023-2024
Leiden University
2022
Structural and mechanistic studies give new insights into calcium-dependent lipopeptide antibiotics that target C 55 -P.
ABSTRACT Directly probing the endogenous biological roles of target proteins with high spatial and temporal resolution, as non-invasively reproducibly possible, is a shared conceptual goal for research across many fields, well targeted therapies. Here we describe rational design test-case practical implementation photopharmacological paradigm to empower high-performance photomodulation studies in vivo . TRPC4/5 ion channels are involved spatiotemporally resolved circuits, from pain anxiety,...
Electron paramagnetic resonance (EPR) spectroscopy is a powerful technique for the study of proteins in solution and under native conditions. Paramagnetic spin centres are usually introduced by site-directed labelling (SDSL) engineered cysteine residues. However, many (membrane) protein classes, engineering not possible without affecting their structural functional integrity. Here, we report development xanthine-based aminoxyl probes that allow non-covalent human TRPC5 ion channels. The...
2-, 4-, 5-, and 6-hydroxynicotinic acids were crystallized in a pH-dependent manner using only water as the preferred solvent. The crystallization outcome was quite diverse: individual crystals of different sizes shapes, microcrystalline powders, crystalline aggregates, almost amorphous solids. Such variety solid forms demonstrates relevance pH control during processes.