A5051519072- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Cardiomyopathy and Myosin Studies
- Radiation Dose and Imaging
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Biotin and Related Studies
- Retinoids in leukemia and cellular processes
- Cardiac Fibrosis and Remodeling
- Histone Deacetylase Inhibitors Research
- Pulmonary Hypertension Research and Treatments
- Advanced X-ray and CT Imaging
- Metabolism and Genetic Disorders
- Cardiovascular Function and Risk Factors
- Radiomics and Machine Learning in Medical Imaging
- Pleural and Pulmonary Diseases
- Meningioma and schwannoma management
- Neonatal Respiratory Health Research
- Oral health in cancer treatment
- Ultrasound and Hyperthermia Applications
- Telomeres, Telomerase, and Senescence
- Medical Imaging and Analysis
- Redox biology and oxidative stress
- Hepatitis B Virus Studies
- Folate and B Vitamins Research
Emory University
2021-2024
Konkuk University Medical Center
2020-2023
Seoul National University Bundang Hospital
2015-2021
University of Arizona
2010-2020
Asan Medical Center
2016
Hanyang University
2007
Hallym University Kangnam Sacred Heart Hospital
2001
Catholic University of Korea
1999-2000
Ajou University
1998-2000
The polypurine/polypyrimidine (pPu/pPy) tract of the human vascular endothelial growth factor (VEGF) gene is proposed to be structurally dynamic and have potential adopt non-B DNA structures. In present study, we further provide evidence for existence G-quadruplex structure within this both in vitro vivo using dimethyl sulfate (DMS) footprinting technique nucleolin as a structural probe specifically recognizing We observed that overall reactivity guanine residues toward DMS was significantly...
Objective: To compare the image quality of low-dose (LD) computed tomography (CT) obtained using a deep learning-based denoising algorithm (DLA) with LD CT images reconstructed filtered back projection (FBP) and advanced modeled iterative reconstruction (ADMIRE).Materials Methods: One hundred routine-dose (RD) abdominal studies FBP were used to train DLA.Simulated made at dose levels 13%, 25%, 50% RD (DLA-1, -2, -3) FBP.We trained DLAs simulated as input data ground truth.To test DLA,...
Background It is uncertain whether a deep learning-based automatic detection algorithm (DLAD) for identifying malignant nodules on chest radiographs will help diagnose lung cancers. Purpose To evaluate the efficacy of using DLAD in observer performance cancers radiographs. Materials and Methods Among patients diagnosed with between January 2010 December 2014, 117 (median age, 69 years; interquartile range [IQR], 64-74 57 women) were retrospectively identified whom visible previous For...
To determine predictors of invasiveness lesions with US-guided biopsy-confirmed ductal carcinoma in situ (DCIS), focusing on US features, including shear wave elastography (SWE).From January 2015 to September 2016, a total 80 DCIS were detected patients who underwent preoperative mammography, B-mode US, and SWE. Data retrospectively reviewed from clinical records, pathologic reports, imaging assessments. Imaging data included mammographic findings, findings based the American College...
To investigate whether monoenergetic images captured with dual-layer spectral computed tomography (CT) can improve the repeatability of subsolid nodule measurement, and this approach further reduce radiation dose CT while maintaining its measurement repeatability.An anthropomorphic phantom simulated nodules at three different levels was repeatedly scanned both conventional single-energy CT. A proxy for in National Lung Screening Trial (proxy NLST) calculated typical protocol used NLST. Using...
In this study, we aimed to assess the prevalence of interstitial lung abnormalities (ILAs) and investigate rates risk factors associated with radiologic ILA progression among patients cancer following surgical resection. Patients who underwent resection for at our institution from January 2015 December 2020 were retrospectively evaluated grouped according their status as having no ILAs, equivocal or ILAs. Progression was determined by simultaneously reviewing baseline corresponding follow-up...
Galactosaemia appears to be one of the most appropriate disorders for routine newborn screening as almost normal outcome can achieved in identified cases. Galactose and galactose‐1‐phosphate were determined using Guthrie cards a commercial kit based on colorimetric microassay. Among 199 642 newborns, nine cases with classic galactosaemia, three epimerase deficiency, six compound Duarte 2 /heterozygotes galactosaemia four homozygosity found. Even though number found among screened neonates is...
This study aimed to evaluate the clinical benefits and risks of CT-guided percutaneous transthoracic needle lung biopsies (PTNBs) in patients with a suspected pulmonary infection. included 351 PTNBs performed 342 (mean age, 58.9 years [range, 17-91 years]) infection from January 2010 December 2016. The proportion that revealed causative organism for influenced patient's treatment were measured. Multivariate analyses identify factors associated PTNB or affected treatment. Finally,...
This research evaluated the diagnostic accuracy and complication rate of computed tomography (CT)-guided percutaneous transthoracic lung biopsy (PTNB) in patients 80 years older. The study sought to identify risk factors for failures or complications PTNBs. We examined 247 CT-guided PTNBs performed from January 2017 through December 2020, noting patient demographics, lesion procedure types, pathology reports, other procedure-related complications. Study groups were divided into two: one with...
Background: Myofibroblasts mediate tissue fibrosis and are a driver of disease progression in heart failure (HF). Reactive oxygen species (ROS) generated by NADPH oxidase-4 (NOX4) required for transforming growth factor-beta (TGFb)-induced myofibroblast activation. Therapeutic targeting NOX4 inhibited development reversed existing an aging model lung fibrosis. However, the cell-specific roles have not been fully explored. Objective: We sought to define cardiac cell-type specific expression...
The polymerase chain reaction in situ hybridization (PCR-ISH) is a new technique that combines the sensitivity of PCR with localizing ability ISH. To investigate expression pattern hepatitis B virus (HBV) tissue hepatocellular carcinoma (HCC), we detected HBV-DNA PCR-ISH paraffin-embedded tumor and corresponding non-tumor tissues from 11 HCC patients. was 4 7 10 tissues. In tissues, positive signals were scattered occasional clustering, found mainly cytoplasm cells rather than nucleus....
Rationale: Idiopathic pulmonary fibrosis (IPF) is a fatal disease, characterized by progressive scar tissue formation leading to respiratory failure.Aging well-recognized risk factor for IPF.However, the contribution of aging cellular/molecular mechanism(s) involved in pathogenesis IPF remains poorly understood.Our previous studies demonstrate that myofibroblast apoptosis promotes resolution young mice, whereas myofibroblasts from aged mice acquire senescent and apoptosis-resistant phenotype...
Comparison of Stress Levels Induced by Two Types Pet Dryers Using Salivary Cortisol Measurement in Dogs The common pet dryer (CD) is typically used to dry dogs after bathing, but the excessive heat and noise can induce stress. Dog owners facilities housing many animals, such as research facilities, have begun widely adopt room (PDR) a more convenient drying alternative. In present study, stress induced CD or PDR was assessed measuring salivary cortisol. Ten healthy beagles at laboratory were...