A5077659318- Dermatology and Skin Diseases
- melanin and skin pigmentation
- Allergic Rhinitis and Sensitization
- Skin Protection and Aging
- Food Allergy and Anaphylaxis Research
- Neonatal skin health care
- Mobile Health and mHealth Applications
- Ethics in Clinical Research
- Insect Utilization and Effects
- Silk-based biomaterials and applications
- Bee Products Chemical Analysis
- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Infant Nutrition and Health
- Atherosclerosis and Cardiovascular Diseases
- Contact Dermatitis and Allergies
- Infant Development and Preterm Care
- Breastfeeding Practices and Influences
- American and British Literature Analysis
- Olfactory and Sensory Function Studies
- HIV/AIDS Research and Interventions
- Psychology of Development and Education
- American Sports and Literature
- Infant Health and Development
- Circadian rhythm and melatonin
University of Nottingham
2015-2024
Queen's Medical Centre
2015-2020
Williams (United States)
2020
University of Aberdeen
1951
BackgroundSkin barrier dysfunction precedes eczema development. We tested whether daily use of emollient in the first year could prevent high-risk children.MethodsWe did a multicentre, pragmatic, parallel-group, randomised controlled trial 12 hospitals and four primary care sites across UK. Families were approached via antenatal or postnatal services for recruitment term infants (at least 37 weeks' gestation) at high risk developing (ie, one first-degree relative with parent-reported eczema,...
Atopic eczema (AE) is a common skin problem that impairs quality of life and associated with the development other atopic diseases including asthma, food allergy allergic rhinitis. AE treatment significant cost burden for health care providers. The purpose trial to investigate whether daily application emollients first year can prevent developing in high-risk infants (first-degree relative or rhinitis). This protocol pragmatic, two-arm, randomised controlled, multicentre trial. Up 1400 term...
Introduction ACOSOG-Z0011(Z11) trial showed that axillary node clearance (ANC) may be omitted in women with ≤2 positive nodes undergoing breast conserving surgery (BCS) and whole radiotherapy (RT). A confirmatory study is needed to clarify the role of treatment macrometastases BCS groups were not included Z11 for example, mastectomy those microscopic extranodal invasion. The primary objective POsitive Sentinel NOde: adjuvant therapy alone versus plus Clearance or (POSNOC) evaluate whether...
Abstract Background The effectiveness of emollients for preventing atopic dermatitis/eczema is controversial. Barrier Enhancement Eczema Prevention trial evaluated the effects daily during first year life on dermatitis and conditions to age 5 years. Methods 1394 term infants with a family history disease were randomized (1:1) emollient plus standard skin‐care advice (693 group) or alone (701 controls). Long‐term follow‐up at ages 3, 4 years was via parental questionnaires. Main outcomes...
Background The role of clothing in the management eczema (also called atopic dermatitis or eczema) is poorly understood. This trial evaluated effectiveness and cost-effectiveness silk garments (in addition to standard care) for children with moderate severe disease. Methods findings was a parallel-group, randomised, controlled, observer-blind trial. Children aged 1 15 y were recruited from secondary care community at five UK medical centres. Participants allocated using online randomisation...
Evidence for the effectiveness of vitiligo treatments is limited. To determine (i) handheld narrowband UVB (NB‐UVB) and (ii) a combination potent topical corticosteroid (TCS) NB‐UVB, compared with TCS alone, localized vitiligo. A pragmatic, three‐arm, placebo‐controlled randomized controlled trial (9‐month treatment, 12‐month follow‐up). Adults children, recruited from secondary care community, aged ≥ 5 years active affecting < 10% skin, were 1 : to receive (mometasone furoate 0·1% ointment...
Atopic eczema (AE) is a chronic, itchy, inflammatory skin condition that affects the quality of life children and their families. The role specialist clothing in management AE poorly understood. To assess effectiveness cost-effectiveness silk garments for with moderate to severe disease. Parallel-group, observer-blind, randomised controlled trial 6 months' duration, followed by 2-month observational period. A nested qualitative study evaluated beliefs participants, health-care professionals...
Background Systematic reviews suggest that narrowband ultraviolet B light combined with treatments such as topical corticosteroids may be more effective than monotherapy for vitiligo. Objective To explore the clinical effectiveness and cost-effectiveness of corticosteroid compared (1) hand-held (2) light/topical combination treatment localised Design Pragmatic, three-arm, randomised controlled trial 9 months a 12-month follow-up. Setting Sixteen UK hospitals – participants were recruited...
Abstract Background Cow's milk allergy (CMA) overdiagnosis in young children appears to be increasing and has not been well characterised. We used a clinical trial population characterise CMA identify individual‐level primary care practice‐level risk factors. Methods analysed data from 1394 born England 2014–2016 (BEEP trial, ISRCTN21528841). Participants underwent formal diagnosis at ≤2 years. was defined three separate ways: parent‐reported reaction; record of hypersensitivity symptoms;...
Food allergy diagnosis in clinical studies can be challenging. Oral food challenges (OFC) are time-consuming, carry some risk and may, therefore, not acceptable to all study participants.To design evaluate an algorithm for detecting IgE-mediated participants who do undergo OFC.An trial the Barrier Enhancement Eczema Prevention (BEEP) were unwilling or unable attend OFC was developed. BEEP is a pragmatic, multi-centre, randomized-controlled of daily emollient first year life primary...
Abstract Background In the UK, approximately 8% of live births are preterm (before 37 weeks gestation), more than 90% whom born between 30 and 36 weeks, forming largest proportion a neonatal units’ workload. Neonatologists cautious in initiating full milk feeds for infants due to fears necrotising enterocolitis (NEC). There is now evidence dispute this fear. Small studies have shown that feeding enterally from birth could result shorter length hospital stay, which important parents,...
Failure to collect outcome data in randomised trials can result bias and loss of statistical power. Further evaluations strategies increase retention are required. We assessed the effectiveness two for a prevention trial using two-by-two factorial study within (SWAT).
Recent discoveries have led to the suggestion that enhancing skin barrier from birth might prevent eczema and food allergy.To determine cost-effectiveness of daily all-over-body application emollient during first year life for preventing atopic in high-risk children at 2 years a health service perspective. We also considered 5-year time horizon as sensitivity analysis.A within-trial economic evaluation using data on resource use quality captured part BEEP trial alongside data. Parents/carers...
Atopic eczema is a common childhood skin problem linked with asthma, food allergy and allergic rhinitis that impairs quality of life.
Eczema is a chronic, itchy skin condition that can have large impact on the quality of life patients and their families. People with eczema are often keen to try out non-pharmacological therapies like silk therapeutic garments could reduce itching or damage caused by scratching. However, effectiveness cost-effectiveness these in management has yet be proven. The CLOTHES Trial will test hypothesis 'silk plus standard care' superior 'standard care alone' for children moderate severe...
Background Economic evidence for vitiligo treatments is absent. Objectives To determine the cost-effectiveness of (i) handheld narrowband ultraviolet B (NB-UVB) and (ii) a combination topical corticosteroid (TCS) NB-UVB compared with TCS alone localized vitiligo. Methods Cost-effectiveness analysis alongside pragmatic, three-arm, placebo-controlled randomized controlled trial 9 months' treatment. In total 517 adults children (aged ≥ 5 years) active affecting < 10% skin were recruited from...
Palmar hyperlinearity is a feature of ichthyosis vulgaris, the monogenic skin disorder caused by FLG loss-of-function mutations.To investigate how well presence or absence hyperlinear palms (HLP) detect genotype in children.STARD criteria are used to report this diagnostic accuracy study. Phenotype and data (four most prevalent null mutations) were obtained from total 3656 children three studies: UK CLOTHES trial (children 1-5 years with moderate-severe atopic eczema); BEEP (2 year olds at...
Introduction Vitiligo is a condition resulting in white patches on the skin. People with vitiligo can suffer from low self-esteem, psychological disturbance and diminished quality of life. often poorly managed, partly due to lack high-quality evidence inform clinical care. We describe here large, independent, randomised controlled trial (RCT) assessing comparative effectiveness potent topical corticosteroid, home-based hand-held narrowband ultraviolet B-light (NB-UVB) or combination two, for...
Abstract Background Education and advice is provided for tinnitus management in all UK audiology clinics. Sound therapy, including provision of hearing aids may be offered, but this often dependent on a clinician’s decision rather than policy. This inconsistent reflects lack evidence around the effectiveness tinnitus. open-label, two-arm multicentre randomised controlled feasibility trial gathered data recruitment, acceptability outcome assessments to determine conducting large investigating...
Abstract Background The most common management strategy for tinnitus provided in the UK audiology clinics is education and advice. This may also be combined with some form of sound therapy (e.g. digital hearing aids). While advice generally by all clinics, there a marked variability provision aids that depends very much on clinical decisions. A recent Cochrane review concluded lack evidence to support or refute aid use as routine intervention people loss. reflected inconsistency UK. aim HUSH...
Abstract Background The HI-Light Trial demonstrated that for active, limited vitiligo, combination treatment with potent topical corticosteroid (TCS) and handheld narrowband ultraviolet B offers a better response than TCS alone. However, it is unclear how to implement these findings. Aim We sought answer three questions: (i) Can be used safely effectively by people vitiligo?; (ii) Should made available as routine clinical care?; (iii) integrated within current healthcare provision? Methods...
Abstract Background Failure to collect outcome data in randomised trials can result bias and loss of statistical power. Further evaluations strategies increase retention are required. We assessed the effectiveness two for a prevention trial using two-by-two factorial study within (SWAT). Methods Parents babies included host were (1) Short message service (SMS) notification prior sending questionnaires at 3, 6, 12 18 months versus no SMS (2) £10 voucher sent with invitation letter primary...