A5014295965- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Respiratory Support and Mechanisms
- Anesthesia and Pain Management
- Airway Management and Intubation Techniques
- Osteoarthritis Treatment and Mechanisms
- Acupuncture Treatment Research Studies
- Inflammatory mediators and NSAID effects
- Pain Management and Placebo Effect
- Flexible and Reconfigurable Manufacturing Systems
Saarland University
2020-2023
Deutsches Herzzentrum München
2023
Charité - Universitätsmedizin Berlin
2023
In this retrospective study, we compared inhaled sedation with isoflurane to intravenous propofol in invasively ventilated COVID-19 patients ARDS (Acute Respiratory Distress Syndrome).Charts of all 20 admitted the ICU a German University Hospital during first wave pandemic between 22/03/2020 and 21/04/2020 were reviewed. Among screened 333 days, was used 97 while 187 for 12 h or more. The effect dose these two sedatives compared. Mixed days excluded.Patients' age (median [interquartile...
Spontaneous breathing is desirable in most ventilated patients. We therefore studied the influence of isoflurane versus propofol sedation on early spontaneous surgical intensive care patients and evaluated potential mediation by opioids arterial carbon dioxide during first 20 h study sedation.We included a single-center subgroup 66 patients, who participated large multi-center trial assessing efficacy safety sedation, with 33 each randomized to or sedation. Both sedatives were titrated depth...
The aim of our prospective, randomized, double-blind, placebo-controlled study was to investigate the effect laser acupuncture on postoperative pain in women undergoing cesarean section.99 (mean age 32 ± 5 years) scheduled for section under spinal anesthesia at Saarland University Hospital Medical Center, Homburg (Germany) were enrolled this trial after giving written consent. Patients randomized two groups receiving a course 3 treatments over days with either active or placebo laser. Each...
BACKGROUND: Contemporary anesthetic circle systems, when used at low fresh gas flows (FGF) to allow rebreathing of anesthetic, lack the ability for rapid dose titration. The small-scale reflection device Anaesthetic Conserving Device (50mL Version; AnaConDa-S) permits administration volatile anesthetics with high-flow ventilators. We compared washin, washout, and sevoflurane consumption using AnaConDa-S versus a system minimal FGF. METHODS: Forty patients undergoing breast surgery were...
Background: Adequate sedation is important for the treatment of ICU patients. AnaConDa (Anesthetic-Conserving-Device; ACD; Sedana Medical, Sweden), connected between ventilator and patient, retains isoflurane during expiration, releases it back inspiration. The reflection efficiency (RefEff) corresponds to percentage expired anesthetic molecules that are re-inspired. We compared RefEff AnaConDa-S (ACD-50) AnaConDa-100 (ACD-100) under laboratory (DRY) simulated clinical conditions (CLIN)...
As volatile anaesthetic gases contribute to global warming, improving the efficiency of their delivery can reduce environmental impact. This be achieved by rebreathing from a circle system, but also reflection with an open intensive care ventilator. We investigated whether such system could increased warming reflector during inspiration and cooling it expiration (thermocycling).The Sedaconda-ACD-S (Sedana Medical, Danderyd, Sweden) was connected between ventilator test lung. Liquid...
Numerous of factors affect the immunological response during surgery. Despite intensive research, impact different anesthetic techniques on immune system remains unclear. Aim this ex vivo / in vitro study was to determine effects general and neuraxial anesthesia monocyte subset alteration release prototypical pro- anti-inflammatory cytokines.Twenty patients undergoing total knee replacement surgery were randomly assigned receive either (ITN) or combined spinal/epidural (CSE). Samples venous...