A5072986244- Congenital Heart Disease Studies
- Microbial Metabolic Engineering and Bioproduction
- Enzyme Catalysis and Immobilization
- Child Abuse and Related Trauma
- Cardiac pacing and defibrillation studies
- Food Quality and Safety Studies
- Protein Structure and Dynamics
- Restraint-Related Deaths
- Fermentation and Sensory Analysis
- Autopsy Techniques and Outcomes
- Fungal and yeast genetics research
- Coronary Artery Anomalies
- Cardiovascular Health and Disease Prevention
- Cardiac Structural Anomalies and Repair
- Shoulder Injury and Treatment
- Mechanical Circulatory Support Devices
- Crime and Detective Fiction Studies
- Cancer Immunotherapy and Biomarkers
- Neuroscience of respiration and sleep
- Cardiovascular Issues in Pregnancy
- Historical Geography and Cartography
- Bladder and Urothelial Cancer Treatments
- Opioid Use Disorder Treatment
- Enzyme Production and Characterization
- Mycorrhizal Fungi and Plant Interactions
Guy's and St Thomas' NHS Foundation Trust
2017-2024
University of California, San Francisco
2024
Ochsner Medical Center
2007-2022
Hammersmith Hospital
2020
Central Baptist Hospital
2020
E Ink (South Korea)
2020
Regis University
2020
Guy's Hospital
2019
Heartland Research Associates
2010-2018
Ochsner Health System
2014-2018
The mechanical motions, which take place in an animal body, are regulated by the same general laws as motions of inanimate bodies. Thus force gravitation acts precisely manner, and degree, on living dead matter; optics most accurately observed all refractive substances belonging to eye; there is no case it can be proved, that animated bodies exempted from any affections liable, except when powers life capable instituting a process, calculated overcome those affections, others, commensurate...
Whether insomnia, a known correlate of depression, predicts depression longitudinally warrants elucidation. The authors examined 555 Wisconsin Sleep Cohort Study participants aged 33-71 years without baseline or antidepressant use who completed and follow-up overnight polysomnography had complete questionnaire-based data on insomnia for 1998-2006. Using Poisson regression, they estimated relative risks (Zung scale score > =50) at 4-year (average) according to symptoms polysomnographic...
The aim was to predict survival of glioblastoma at 8 months after radiotherapy (a period allowing for completing a typical course adjuvant temozolomide), by applying deep learning the first brain MRI completion.
Our objectives were to examine the heritability of arterial stiffness measured as pulse-wave velocity (PWV), and its dependence on ethnicity, gender, blood pressure (BP). As part Georgia Cardiovascular Twin Study, we aorto-radial (radial) aorto-dorsalis-pedis (foot) PWV in 702 twins (41% black; 49% male) aged 12 30 years (mean age, 17.7 ± 3.3 years), including monozygotic dizygotic pairs same well opposite gender. Ethnicity gender effects genetic environmental contributions estimated by...
The gene encoding an acid extracellular protease (AXP) from Yarrowia lipolytica (Candida olea) 148 was cloned and the complete nucleotide sequence determined. amino deduced reveals that mature AXP consists of 353 acids with M r 37427. also encodes a putative 17 hydrophobic prepeptide 27 propeptide containing no potential N-glycosylation sites. enzyme is produced by cleavage between Phe Ala. member aspartyl family proteases. shows homology to proteases several fungal genera human...
Candida olea 148 secreted a single acid protease when cultured at acidic pH. In unbuffered medium, the culture pH eventually became alkaline and was produced. This only proteolytic enzyme produced organism grown in buffered medium Both enzymes were purified to homogeneity (as assessed by SDS-PAGE). The Mr of 30900, isoelectric point 4.5; optimum activity against haemoglobin 42 degrees C 3.3. inactivated temperatures above 46 inhibited either pepstatin diazoacetyl-norleucine methyl ester but...
Since the degree and manner in which circulation of blood depends upon muscular elastic powers heart arteries are questions belonging to most refined departments hydraulics, author has already submitted Society those general principles he designs, present lecture, 1st, inquire what would be nature if vessels were as inelastic glass or bone; 2ndly, pulse transmitted tubes merely elastic; 3rdly, actions may ascribed their coats; and, lastly, disturbances occasioned different kinds fevers...
Summary: The pH-regulated expression of the acid (AXP) and alkaline (AEP) extracellular proteases yeast Yarrowia lipolytica 148 was analysed. Expression in batch continuous cultures determined at mRNA level by Northern blotting, enzyme assays Western blotting. Culture pH regulated AEP AXP predominantly content. Highest levels were detected 6.5 whereas highest 5.5. At values either side these maxima progressively down-regulated. For both enzymes, variation with culture occurred rather than...
Yeast belonging to various genera were screened for extracellular protease activity. Of the 119 strains examined most prolific producers belonged Candida, Kluyveromyces and Hansenula. No of Sacharomyces found secrete protease. In general only those proteases secreted by genus Candida possessed chill-proofing However one strain Debaryomyces Pichia also produced with
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A critical comparison has been made of the relative efficacy primary purification an extracellular acid protease produced by yeast Yarrowia lipolytica. The performance conventional, discrete sequences fermentation, broth clarification and fixed bed, anion exchange chromatography compared with fluidised bed adsorption directly interfaced post-term fermentation integrated productive fermentations (so-called direct product sequestration; DPS). Advantages latter, in terms improved yield...
The use of U.S. vital statistics for surveillance drug-related mortality may be limited by the way in which certifiers complete death certificates and constraints International classification diseases, Ninth Revision (ICD-9). ICD-9 is system used National Center Health Statistics (NCHS) to compile national, cause-specific data from information reported on certificates. To investigate extent variability certification practices among medical examiners (MEs), we conducted a mailout survey asked...
Septa in the sporangiophore of Tieghemiomyces californicus, as revealed by light, scanning, and transmission electron microscopy, comprise a crosswall with flared, lenticular central pore region which encloses an electron-dense biumbonate plug. On each side septum, closely associated plug, is amorphous, electron-dense, globose body lacking bounding membrane. The consists central, sometimes stratified, electron-lucent layer overlain layer. vegetative hypha are structurally similar. liberated...