Background Functional magnetic resonance imaging (fMRI) continues to develop as a clinical tool for patients with brain cancer, offering data that may directly influence surgical decisions. Unfortunately, routine integration of preoperative fMRI has been limited by concerns about reliability. Many pertinent studies have undertaken involving healthy controls, but work tumor limited. To fully tool, it will be critical examine these reliability issues among tumors. The present is the first...

There are no disease modifying therapies for Huntington's (HD), a rare but fatal genetic neurodegenerative condition. To develop and test new management strategies, better understanding of the mechanisms underlying HD progression is needed. Aberrant changes in thalamo-cortical striato-cerebellar circuitry have been observed asymptomatic HD, along with transient enlargement dentate nucleus. evaluate relationship between thalamo-cerebellar connectivity progression. Prospective retrospective....

With extensive research efforts in place to address the clinical relevance of cerebral microbleeds (CMBs), there remains a need for fast and accurate methods detect quantify CMB burden. Although some computer-aided detection algorithms have been proposed literature with high sensitivity, their specificity consistently poor. More sophisticated machine learning appear be promising ability minimize false positives (FP) through high-level feature extraction discrimination hard-mimics. To achieve...

Deep brain stimulation (DBS) of the anterior limb internal capsule (ALIC) has been used to treat refractory obsessive-compulsive disorder (OCD) and depression, but outcomes are variable, with some patients not responding this form invasive neuromodulation. A lack benefit in may be due suboptimal positioning DBS leads. Recently, studies have suggested that specific white matter tracts within ALIC associated improved outcomes. Here, we present case a patient who initially had modest...

Background Although radiation therapy (RT) contributes to survival benefit in many brain tumor patients, it has also been associated with long‐term injury. Cerebral microbleeds (CMBs) represent an important manifestation of radiation‐related Purpose To characterize the change size and number CMBs over time evaluate their relationship white matter structural integrity as measured using diffusion MRI indices. Study Type Longitudinal, retrospective, human cohort. Population In all, 113 patients...

An optical coherence tomography (OCT) microvascular imaging platform, consisting of Doppler (DOCT) and speckle variance (svOCT) modalities, image quantification tools are developed. The methods extract blood flow-related parameters from DOCT images vessel morphological svOCT images. This platform is used to assess the (DOCT svOCT) obtained during a clinical study on late oral radiation toxicity. specific pathology was considered suitable scenario for verifying performance developed because...

Object: Preoperative functional magnetic resonance imaging (fMRI) remains a promising method to aid in the surgical management of patients diagnosed with brain tumors. For that are candidates for awake craniotomies, decisions can potentially be improved by fMRI but this depends on level concordance between preoperative maps and provided gold standard intraoperative method, direct cortical stimulation (DCS). There have been numerous studies DCS using sensitivity specificity measures, however...

Background Pathophysiological changes of Huntington's disease (HD) can precede symptom onset by decades. Robust imaging biomarkers are needed to monitor HD progression, especially before the clinical onset. Purpose To investigate iron dysregulation and microstructure alterations in subcortical regions as biomarkers, associate such with motor cognitive impairments. Study Type Prospective. Population Fourteen individuals premanifest (38.0 ± 11.0 years, 9 females; far‐from‐onset N = 6,...

Abstract The ability of humans to coordinate stereotyped, alternating movements between the two legs during bipedal walking is a complex motor behavior that requires precisely timed activities across multiple nodes supraspinal network. Understanding neural network dynamics underlie natural in limited. We investigated cortical and subthalamic overground evaluated spectral biomarkers decode gait cycle three patients with Parkinson’s disease without disturbances. Patients were implanted chronic...

A computerized platform has been developed to enhance behavioral testing during intraoperative language mapping in awake craniotomy procedures. The system is uniquely compatible with the environmental demands of both operating room and preoperative functional MRI (fMRI), thus providing standardized toward improving spatial agreement between 2 brain techniques. Details architecture, its advantages over traditional methods, use for are described. Four illustrative cases demonstrate efficacy...

PURPOSE: Precise quantification of cerebral arteries can help with differentiation and prognostication cerebrovascular disease. Existing image processing segmentation algorithms for magnetic resonance angiography (MRA) are limited to the analysis either 2D maximum intensity projection images or entire 3D volume. The goal this study was develop a fully automated, hybrid 2D-3D method robust accurate vessel radii using MRA at varying thicknesses. METHODS: A novel algorithm that employs an...

The importance and benefits of interdisciplinary practice in health care have been well documented. Despite this, few medical schools developed formal curriculum opportunities for teaching. Here, as an example nursing students teaching learning together, we describe a novel approach to peer-assisted led by on fluid electrolyte balance.Teaching sessions were collaborative group fourth-year students, under the supervision staff. Each session had different stations aimed at encouraging...

OBJECTIVE Direct visualization of the ventral intermediate nucleus (VIM) thalamus on standard MRI sequences remains elusive. Therefore, deep brain stimulation (DBS) surgery for essential tremor (ET) indirectly targets VIM using atlas-derived consensus coordinates and requires awake intraoperative testing to confirm clinical benefits. The objective this study was evaluate utility proton density (PD)–weighted tractography intersecting dentato-rubro-thalamic tract (DRTT) direct “intersectional”...

Quantitative susceptibility mapping (QSM) is a promising tool for investigating iron dysregulation in neurodegenerative diseases, including Huntington's disease (HD). Many diverse methods have been proposed to generate accurate and robust QSM images. In this study, we evaluated the performance of different dipole inversion algorithms iron-sensitive imaging at 7T on healthy subjects large age range patients with HD. We compared an iterative least-squares-based method (iLSQR), that use...

Although combined spin‐ and gradient‐echo (SAGE) dynamic susceptibility‐contrast (DSC) MRI can provide perfusion quantification that is sensitive to both macrovessels microvessels while correcting for T 1 ‐shortening effects, spatial coverage often limited in order maintain a high temporal resolution DSC quantification. In this work, we SAGE echo‐planar imaging (EPI) sequence with simultaneous multi‐slice (SMS) excitation blipped controlled aliasing parallel (blipped CAIPI) at 3 achieve...

Stepping and arm swing are stereotyped movements that require coordination across multiple muscle groups. It is not known whether the encoding of these in human primary motor cortex confined to limbs' respective somatotopy. We recorded subdural electrocorticography activities from hand/arm area 6 subjects undergoing deep brain stimulation surgery for essential tremor Parkinson's disease who performed stepping (all patients) (n = 3 tasks. show stepping-related low frequency oscillations over...

Neurocognitive deficits in pediatric cancer survivors occur frequently; however, individual outcomes are unpredictable. We investigate clinical, genetic, and imaging predictors of neurocognition survivors, with a focus on central nervous system (CNS) tumors exposed to radiation.One hundred eighteen patients benign or malignant cancers (median diagnosis age: 7; 32% embryonal CNS tumors) were selected from an existing multi-institutional cohort (RadART Pro) if they had: 1) neurocognitive...