Background: The outbreak of the COVID-19 pandemic brought unique challenges to field healthcare, particularly surgical field. This retrospective cohort study aims compare risk site infection (SSI) and secondary between colorectal cancer (CRC) patients with a history those without. Method: A 200 CRC patients, comprising 100 documented without, were retrospectively analyzed. Independent sample t-tests for continuous variables, Chi-square tests categorical additionally univariate multivariate...

Aim: Subclinical hypothyroidism (SCH) is frequently observed in patients with type 2 diabetes mellitus (T2DM) and may exacerbate macrovascular complications due to its impact on metabolic thyroid function parameters. This study aims explore the association between varying levels of thyroid-stimulating hormone (TSH) risk complications, alongside analyzing key metabolic, demographic, clinical factors T2DM SCH. Methods: A retrospective was conducted at Second Affiliated Hospital Dalian Medical...

Abstract Background Streptococcus agalactiae or group B (GBS) asymptomatically colonizes the genitourinary tracts of up to 30% pregnant women. Globally, GBS is an important cause neonatal morbidity and mortality. has recently been linked adverse pregnancy outcomes. The potential interactions between vaginal microbiome composition remain poorly understood. In addition, little known about microbiota Egyptian Results Using V3-V4 16S rRNA next-generation sequencing, we examined in...

Recently, we identified a novel receptor, CD134, which interacts with the human herpesvirus 6B (HHV-6B) glycoprotein (g)H/gL/gQ1/gQ2 complex and plays key role in entry of HHV-6B into target cells. However, details interaction between gH/gL/gQ1/gQ2 CD134 were unknown. In this study, cysteine-rich domain (CRD), CDR2, that is critical for binding to infection. Furthermore, found expression gQ1 gQ2 subunits was sufficient binding, different from 6A (HHV-6A) its CD46. Finally, region function....

Microbial communities residing in the nose play important roles human health and disease. We report marked differences nasal microbiota between a rural community an industrial setting located near major urban city. Nasal samples were collected from 19 healthy male subjects: 9 persons living village, 10 ceramic factory workers Egyptian The sample had higher distinct diversity compared with exposed to pollution daily. Taxonomic analysis of sequences revealed five phyla; among these phyla...

The tegument protein U14 of human herpesvirus 6B (HHV-6B) constitutes the viral virion structure and is essential for growth. To define characteristics functions U14, we determined crystal N-terminal domain HHV-6B (U14-NTD) at 1.85 Å resolution. U14-NTD forms an elongated helix-rich fold with a protruding β hairpin. exists as dimer exhibiting broad electrostatic interactions network hydrogen bonds. This first report dimerization U14. surface reveals multiple clusters negatively-...

Glycoprotein O (gO) is conserved among betaherpesviruses, but little known about the maturation process of gO in human herpesvirus 6 (HHV-6). We found that HHV-6 was accompanied by cleavage its carboxyl terminus and required coexpression gH gL, which promoted export out endoplasmic reticulum (ER). Finally, we also not for HHV-6A growth T cells.

Escherichia coli is one of the most important etiologic agents childhood diarrhea that represents a major public health problem in developing countries and now being recognized as emerging entero-pathogens well developed countries. Among diarrhegenic Coli (DEC) this work was focused on Enterohemorrhagic (EHEC) produce Shigatoxins (Stxs). The infection mainly transmitted through food bovine origin such beef dairy products has been often associated with outbreaks which ranged from mild to...

Bacteria regulate their social activities and physiological processes through a quorum sensing (QS) mechanism. Many bacteria inhabit the mesohyl matrix of sponges. This symbiotic relationship is believed to contribute health nutrition sponges by production protective antibiotics, acquisition limiting nutrients nitrogen fixation. Marine isolates were analysed bioassays using two different acylated homoserine lactone (AHL) reporter Chromobacterium violaceum 026 (CV026) Agrobacterium...

Chlamydial and gonococcal infections are recognized as two of the major causes sexually transmissible human bacterial infection which may lead to infertility. In this cross sectional study, we aimed determine prevalence Neisseria gonorrhoeae, Chlamydia trachomatis among Egyptian women using different microbiological methods. One hundred fifty cervical swabs were collected, 100 from infertile women. Culture ELISA technique used for screening gonorrhoeae individually. addition, PCR was all...

Marine and ecosystem pollution due to oil spills can be addressed by identifying the aromatic hydrocarbon (HC)-degrading microorganisms their responsible genes for biodegradation. Moreover, screening coding secondary metabolites is invaluable drug discovery. We report here, first metagenomic study investigating shotgun metagenome of Suez Canal water sampled at Ismailia city concerning its HC degradation potential in comparison seawater Halayeb Red Sea Sallum Mediterranean Sea. an in-depth...

Phyllodes tumor (PT) is a variant of fibroepithelial proliferations the breast, histologically demonstrating leaf-like pattern. The WHO has categorized PTs as benign, borderline, or malignant based on their histological characteristics. objective this paper to assess clinicopathological factors with malignancy in PT breast. Medical records 101 diagnosed patients Second Affiliated Hospital Dalian University between 2008 and 2023 were reviewed. Information clinical presentation...

Human herpesvirus 6A (HHV-6A) glycoprotein B (gB) is a consisting of 830 amino acids and essential for the growth virus. Previously, we reported that neutralizing monoclonal antibody (MAb) called 87-y-13 specifically reacts with HHV-6A gB, identified its epitope residue at asparagine (Asn) 347 on gB. In this study, examined whether recognized by MAb infection. We constructed bacterial artificial chromosome (BAC) genomes harboring substitutions Asn347, namely, BACgB(N347K) BACgB(N347A). These...

In 1869, the Suez Canal was opened, which brought waters of Mediterranean and Red Sea into direct contact. Notably, constructed for navigation purposes without focusing on ecological impacts. The paved way species migration from to through Lessepsian migration, named after Ferdinand de Lesseps, while is called anti-Lessepsian migration. It has been argued in past that migrating had negative consequences host environment as well humans. Few studies date have attempted map microorganism...

Abstract The aim of this study is to evaluate the effect radiotherapy (RT) as one modalities treatment in patients with head and neck tumors on Eustachian tube middle ear. This a prospective study. included 20 suffering from squamous cell carcinoma other than nasopharynx parotid. They were treated either by surgery postoperative or primary alone concomitant chemoradiotherapy. Audiological evaluation was performed both pre-treatment post- form pure tone threshold audiometry (PTA),...