We investigated the gut microbiota in patients with non-alcoholic fatty liver disease (NAFLD) and its correlation fibrosis steatosis stratified by body mass index, as reflected controlled attenuation parameter transient elastography values. A cross-sectional study was performed on 37 NAFLD at Cipto Mangunkusumo National General Hospital from December 2018 to March 2019. The fecal samples 16S RNA sequencing using MiSeq next-generation platform (Illumina). more common metabolic syndrome....

Pandemi Coronavirus disease 2019 (COVID-19) telah berlangsung sejak Maret 2020 hingga saat ini sudah hampir dua tahun melanda dunia, tak terkecuali Indonesia. Dalam perjalanannya sebagai patogen, SARS-CoV-2 mengalami beberapa mutasi menjadi berbagai varian yang perhatian dunia. Varian-varian virus dikhawatirkan menghambat resolusi wabah, bahkan membuat wabah tidak terkendali. Masih banyak kontroversi dan riset berjalan tentang varian-varian baru SARS-CoV-2. Mekanisme penularan cepat belum...

Background: White light imaging (WLI) is the current standard colonoscopy technique for diagnosing colorectal polyps in Indonesia. Various endoscopic techniques have been developed to improve accuracy of polyps, one which narrow band (NBI). We conducted a diagnostic study comparing performance NBI against WLI distinguishing neoplastic from non-neoplastic polyps. Methods: This was that analyzes pictures patients who underwent using and techniques. Previously collected biopsy tissue specimens...

Abstract Background and aims Hepatocellular carcinoma (HCC), the most common type of liver cancer, is one leading causes cancer-related death worldwide with an inferior prognosis. In Indonesia, average life expectancy less than 5 months, patients being in advanced stage wherein survival rate very low. Early detection through surveillance program crucial. HCC guidelines have provided recommendation examination α-fetoprotein (AFP) ultrasound for at risk developing HCC. However, there been some...

Non-alcoholic fatty liver disease (NAFLD) is an emerging disease, where it can progress to non-alcoholic steatohepatitis (NASH) and lead cirrhosis or cancer. Small intestinal bacterial overgrowth (SIBO) has been hypothesized play important role in NAFLD development progression, however, there still conflicting data about this phenomenon. Transient Elastography (TE) examination using controlled attenuation parameter (CAP) validated for progression assessment NAFLD. It non-invasive method easy...

Whether acute or chronic, liver failure is a state of dysfunction that can progress to multiorgan failure. Mortality in patients approximately 80–90% and caused by detoxification failure, which triggers other immediate complications, such as encephalopathy, coagulopathy, jaundice, cholestasis, kidney The ideal treatment for transplantation, but the long waiting period right donor match causes unavoidable deaths most patients. Therefore, new therapies, tissue engineering, hepatocyte stem...

Based on genetic and antigenic differences their cell tropism, human herpes virus-6 (HHV-6) has been classified into two variants, HHV-6A HHV-6B. Recently, these variants were re-classified as different species. The glycoprotein complex, gH/gL/gQ1/gQ2 binds to its cellular receptor, CD46; however, the corresponding complex in HHV-6B rarely CD46. To determine which viral molecules HHV-6A-CD46 binding, each molecule of (i.e., gH, gL, gQ1, or gQ2) was replaced with molecule, ability protein be...

Diabetes mellitus (DM) is a significant risk factor for peripheral arterial disease (PAD). PAD affects 20% of DM patients over 40 and has increased by 29% in the last 50 years. The gut microbiota produces short-chain fatty acids (SCFAs) that affect atherosclerosis. SCFA inhibits inflammation, which contributes to This study tried link feces levels atherosclerosis people with diabetes included 53 PAD: gas chromatography-mass spectrometry measured acetate, butyrate, propionate samples (GC-MS)....

Human herpesvirus 6 (HHV-6) is a T-lymphotropic virus belonging to the betaherpesvirus family. Several HHV-6-encoded glycoproteins are required for cell entry and virion maturation. Glycoprotein M (gM) conserved among all herpesviruses, therefore thought have important functions; however, HHV-6 g has not been characterized. Here, we examined expression of g, its function in viral replication, using mutant revertant gM. was expressed on virions as glycoprotein modified with complex N-linked...

Abstract Portal hypertension (PH) poses significant challenges. This paper presents an innovative study on the utilization of endoscopic ultrasound (EUS) for both diagnosis and management PH. Conducted at Dr. Cipto Mangunkusumo National General Hospital in Jakarta, this retrospective case series included patients diagnosed with PH through clinical examination, imaging evaluation, esophagogastroduodenoscopy. Exclusion criteria comprised a history reduced blood consumption within last 5 days,...

<ns4:p><ns4:bold>Background: </ns4:bold>Persistent immune activation and inflammation in HIV-infection are linked to excess cardiovascular risk other non-communicable diseases. Periodic asymptomatic CMV-reactivity HIV infected patients over a lifetime may contribute non-AIDS defining morbidity. Despite undetectable levels of CMV, these continue have increased biomarkers activations. Statin administration is thought reduce subclinical atherosclerosis by decreasing LDL-C levels. It also add...

A liver organoid is an in vitro reconstruction of the that mimics vivo microstructure and performs functions. Liver organoids can be used for drug testing, as a model disease pathogenesis, bioartificial prototype material to develop promising alternative therapies failure. In this study, we reconstructed using primary rat hepatocytes, hepatic stellate cell line (LX2), human umbilical cord-mesenchymal stem cells (UC-MSCs), cord blood (UCB)-CD34+ hematopoietic stem/progenitor cells....

Human herpesvirus 6 (HHV-6) is a T-lymphotrophic virus belongs to the genus Roseolovirus within beta subfamily. The U20-U24 gene cluster unique Roseoloviruses; however, both their function and whether they are essential for growth unknown. Recently, bacterial artificial chromosome (BAC) techniques have been used investigate HHV-6A. This study describes generation of genome lacking U21-U24 (HHV-6ABACΔU21-24) shows that infectious particles can be reconstituted from this BAC DNA. Our data...

Abstract Aim The presence of esophageal collateral veins (ECV) has been reported to be associated with the recurrence varices (EV) and bleeding in liver cirrhotic (LC) patients. This study aimed see potential clinical value deep assessment using endoscopic ultrasound (EUS) patients EV. Methods During 6 months period, a prospective is conducted, where we identified LC who were admitted for esophagogastroduodenoscopy (EGD) screening at Department Internal Medicine, Dr. Cipto Mangunkusumo...

Abstract Background Anxiety and depression are psychosomatic disorders that frequently observed in chronic conditions such as systemic lupus erythematosus (SLE). can be induced by immunological neurotransmitter dysregulation, which is characterized hypothalamic–pituitary–adrenal (HPA) axis dysfunction, production of proinflammatory cytokines, activation complement the blood, C3 C4. The causes anxiety SLE complex, ranging from neuropsychiatric involvement to drug adverse effects. Detecting...

Gastric varices (GVs) occur in 10-30% of liver cirrhotic patients, with a mortality rate up to 45%. Rupture isolated GVs (IGVs) is less prevalent but often results more severe hemorrhage and higher risk than rupture esophageal (EVs). However, there no clear consensus yet about the optimal management for incidentally discovered IGVs.To determine clinical significance IGVs patients.This was retrospective cohort endoscopy database study within 2-year period (2016-2017). All subjects were...