A5001481996- Electromagnetic Fields and Biological Effects
- Electrospun Nanofibers in Biomedical Applications
- Immune Cell Function and Interaction
- Liver physiology and pathology
- Tissue Engineering and Regenerative Medicine
- Education and Critical Thinking Development
- Pancreatic function and diabetes
- CAR-T cell therapy research
- Virus-based gene therapy research
- Biopolymer Synthesis and Applications
- Cancer Research and Treatment
- Nutrition, Genetics, and Disease
- Hydrogels: synthesis, properties, applications
- Andrographolide Research and Applications
- Immune cells in cancer
- Medicinal Plant Research
- Musculoskeletal pain and rehabilitation
- Online Learning and Analytics
- Orthopaedic implants and arthroplasty
- Spine and Intervertebral Disc Pathology
- biodegradable polymer synthesis and properties
- Innovative Teaching and Learning Methods
- Animal Genetics and Reproduction
- Biofield Effects and Biophysics
- Spaceflight effects on biology
University of Indonesia
2020-2025
Syarif Hidayatullah State Islamic University Jakarta
2018
Objective: This study aims to investigate the possibility of additive cytotoxic effects cisplatin and Andrographis paniculate (Burm. f.) Nees(AP) via apoptotic, cell cycle angiogenesis pathways. Methods: CC50 cisplatin, AP Andrographolide (AG) were determined by viability SKOV3 after its exposure these substances. cells then divided into 6 experimental groups: one negativecontrol group, with alone, three where was combined AP, ½CC50 1.5CC50 respectively. The effect or AG evaluated through...
Mesenchymal stem cells (MSC) and induced pluripotent (iPSC) have been reported to be able differentiate hepatocyte in vitro with varying degree of maturation. A simple method decellularize liver scaffold has established by the Department Histology, Faculty Medicine, Universitas Indonesia, SCTE IMERI lab.15 This study aims evaluate differentiation from iPSCs compared MSCs derived our decellularized scaffold. The research stages started iPSC culture, decellularization, seeding cell culture...
A liver organoid is an in vitro reconstruction of the that mimics vivo microstructure and performs functions. Liver organoids can be used for drug testing, as a model disease pathogenesis, bioartificial prototype material to develop promising alternative therapies failure. In this study, we reconstructed using primary rat hepatocytes, hepatic stellate cell line (LX2), human umbilical cord-mesenchymal stem cells (UC-MSCs), cord blood (UCB)-CD34+ hematopoietic stem/progenitor cells....
Various implant treatments, including total disc replacements, have been tried to treat lumbar intervertebral (IVD) degeneration, which is claimed be the main contributor of lower back pain. The however, come with peripheral issues. This study proposes a novel approach that complies anatomical features IVD, so-called monolithic replacement (MTDR). As name suggests, MTDR one-part device consists lattice and rigid structures mimic nucleus pulposus annulus fibrosus, respectively. can made two...
Bone morphogenetic protein 2 (BMP-2) is a or growth factor that plays an important role in osteogenic differentiation. Recently, there increasing demand for BMP-2, as it the only osteoinductive approved by Food and Drug Administration (FDA) substitute bone grafts. However, recombinant BMP-2 production suffers from low yields changes biological function of due to efficiency translocation hosts. One key regulators influences signal peptide (SP). SP regulates process post-translational...
Background: Reprogrammed cell therapy has not been applied for clinical purposes due to the malignancy issue. The aim of this study was design recombinant vector transcription factors and analyze effectiveness cell-penetrating peptide delivering system human primary fibroblast transfection avoid issue.Materials methods: constructions CCAT/enhancer binding protein alpha (CEBPA), hepatocyte nuclear factor 4 (HNF4A), receptor subfamily 1 group I member 2 (NR1I2) were confirmed with DNA...
The pathway for the introduction of NK cell into abnormal cells is mediated by receptor-ligand interaction on surface. Among all activation receptors, NKP44 has become a unique receptor because it an ITIMs signaling and actively plays important role in several functions stimulated cells. A potential ligand that can specifically regulate activity receptors NID1. NID1 novel initiate two different regulations activity. In addition, also provides predictions are compatible with electrophoretic...
Ovarian cancer is one of the gynecologic cancers with a high mortality rate and increased incidence. Surgery therapies are used to treat ovarian patients. Therapies such as chemotherapy radiotherapy can cause resistance therefore immunotherapy using natural killer (NK) cells be an alternative therapy. NK have shown important role in anticancer activity because it able kill target without prior sensitization acquire immunology memory. However, low capacity efficacy on infiltrating cancer's...
Scientific reasoning is useful in order to solving problems life.The discussion of socioscientific issues has potential improve students' scientific reasoning.This research aimed determine the use virus and improving used experimental method with two group pretest posttest design.Sample was students class X SMAN 87 Jakarta academic year 2016/2017.Sample divided into 1 2. Each consisted 32 students.The learning process methods that are issues.The abilities were excavated through test form...
Abstract Pulsed electromagnetic fields (PEMFs) have an important role in cell differentiation. Previous study reported that PEMFs had positive and negative effect towards differentiation depends on their frequencies applied to the cells. Human adipose-derived stem cells (ASCs) are mesenchymal ability differentiate into several types of including adipocytes, chondrocytes osteocytes. This aimed evaluate human ASCs adipogenic during exposure. were isolated from adipose tissue. The then cultured...