Defang Chen

ORCID: 0000-0001-7975-1787
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About
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Research Areas
  • Urinary Bladder and Prostate Research
  • Neuroscience of respiration and sleep
  • Neonatal Respiratory Health Research
  • Fungal Biology and Applications
  • Neonatal and Maternal Infections
  • Seaweed-derived Bioactive Compounds
  • Neurogenetic and Muscular Disorders Research
  • Gastrointestinal disorders and treatments
  • Endometriosis Research and Treatment
  • Mechanical stress and fatigue analysis
  • RNA modifications and cancer
  • Traumatic Brain Injury Research
  • Appendicitis Diagnosis and Management
  • Glaucoma and retinal disorders
  • Retinal Imaging and Analysis
  • Wound Healing and Treatments
  • Urologic and reproductive health conditions
  • Alzheimer's disease research and treatments
  • Pelvic floor disorders treatments
  • Neuroendocrine regulation and behavior
  • Nanoparticles: synthesis and applications
  • Hydrogels: synthesis, properties, applications
  • Polysaccharides and Plant Cell Walls
  • RNA Research and Splicing
  • Medical Imaging Techniques and Applications

Jinan Central Hospital
2013-2024

Shandong First Medical University
2020-2024

Sichuan University
2023

West China Hospital of Sichuan University
2023

University of Science and Technology of China
2023

Nanchang Institute of Science & Technology
2021

Shandong University
2013-2020

Ministry of Culture
2010

Third People 's Hospital of Chongqing
2006

Spinal muscular atrophy (SMA), which results from the deletion or/and mutation in SMN1 gene, is an autosomal recessive neuromuscular disorder that leads to weakness and muscle atrophy. SMN2 a paralogous gene of SMN1. copy number affects severity SMA, but its role patients treated with disease modifying therapies unclear. The most appropriate individualized treatment for SMA has not yet been determined. Here, we reported case type I normal breathing swallowing function. We genetically...

10.1093/hmg/ddae052 article EN cc-by Human Molecular Genetics 2024-03-23

Stress urinary incontinence (SUI) is more common in women than men, and sex differences anatomic structure physiology have been suggested as causes; however, the underlying cellular molecular mechanisms remain unclear. The spontaneous tone (STT) of urethra has shown to a fundamental effect on preventing occurrence SUI. Here, we investigated whether urethral STT exhibited differences. First, isolated smooth muscle (USM) detected female mice women. No was found male or men. Furthermore,...

10.1152/ajprenal.00174.2020 article EN AJP Renal Physiology 2020-07-20

In recent years, nanoparticles have been widely used in many fields, ranging from cosmetics, agriculture, environment, and biomedical areas. The increasing use of nanoproducts induces a potential exposure to human body, then, unknown pathological consequences could increase.The database was searched 2008 2018 by the Web Science Core Collection. bibliometric methods, CiteSpace HistCite, were for analysis visualization data.The 2932 publications analyzed annual grew 78 512 decade. United...

10.1177/0748233719900844 article EN Toxicology and Industrial Health 2020-01-01

Conditional image synthesis based on user-specified requirements is a key component in creating complex visual content. In recent years, diffusion-based generative modeling has become highly effective way for conditional synthesis, leading to exponential growth the literature. However, complexity of modeling, wide range tasks, and diversity conditioning mechanisms present significant challenges researchers keep up with rapid developments understand core concepts this topic. survey, we...

10.48550/arxiv.2409.19365 preprint EN arXiv (Cornell University) 2024-09-28

Bleeding and infection can cause significant increases in mortalities. Hydrogel sealants have attracted extensive attention for their ability to control bleeding. In this study, the adjuvant treatment with antibacterial adhesive hydrogel dressings was applied patients deep second-degree burns/scalds. The traditional medical dressing regarded as treatment. results indicated that total positive rate of bacteria wound secretions pain during change who used were significantly reduced. number...

10.1155/2021/8212518 article EN Computational and Mathematical Methods in Medicine 2021-11-30

Background: As an emerging arrhythmia monitor, ambulatory smartwatch electrocardiogram (ECG) provides option for home-based monitoring of delayed new-onset arrhythmic events after transcatheter aortic valve replacement (TAVR). We aimed to validate the diagnostic efficacy a consumer ECG in TAVR recipients, while further explore occurrence rate both tachy- and brady-arrhythmia 30 days discharge support risk management. Methods: Consecutive recipients from February 26th, 2021 December 13th,...

10.31083/j.rcm2401011 article EN cc-by Reviews in Cardiovascular Medicine 2023-01-04

This paper introduces LCPNN, a novel complex neural network that leverages Laplacian pyramid methodologies to effectively reconstruct magnetic resonance images of superior quality from sparsely sampled k-space data. The study elucidates three pivotal contributions: 1) implementation framework adeptly exploits the advantageous multi-scale attributes decomposition, 2) formulation sequential structure integrates intricate convolutions within aforementioned framework, and 3) verification...

10.1109/ccis59572.2023.10263273 article EN 2022 IEEE 8th International Conference on Cloud Computing and Intelligent Systems (CCIS) 2023-08-12

Abstract This study explored factors influencing ellipsoid zone (EZ) tear in pathologic myopia choroidal neovascularization (PM-CNV) and its relationship with visual acuity mainly using optical coherence tomography (OCT). We divided 21 (22 eyes) PM-CNV patients, who were into non-tear (n=10) (n=12) groups by whether the EZ was torn or not. Measured central macular thickness (CMT), lesion hyperreflectivity (HF) height area, myoid (MEZ)) on OCT. Analyzing relationships between these tearing....

10.21203/rs.3.rs-1645165/v1 preprint EN cc-by Research Square (Research Square) 2022-05-19

Research shows that the sports risks of enthusiasts and professional athletes are not only caused by a single reason, but usually superposition multiple factors. Traditional risk assessment methods can assess existing in sports, there problems such as long time-consuming process poor accuracy, which be used for large-scale assessment. Therefore, this paper puts forward an evaluation model method improper exertion injury track field based on big data network analysis. The makes multi-layer...

10.1145/3482632.3487512 article EN 2021-09-24
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