A5057850950- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Restless Legs Syndrome Research
- Botulinum Toxin and Related Neurological Disorders
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Amyotrophic Lateral Sclerosis Research
- Obsessive-Compulsive Spectrum Disorders
- Cerebrospinal fluid and hydrocephalus
- Palliative Care and End-of-Life Issues
- Childhood Cancer Survivors' Quality of Life
- Neuroblastoma Research and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Cancer survivorship and care
- Neurology and Historical Studies
- Distributed and Parallel Computing Systems
- Parkinson's Disease and Spinal Disorders
- Simulation-Based Education in Healthcare
- Glioma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Surgical Simulation and Training
- Balance, Gait, and Falls Prevention
- Dementia and Cognitive Impairment Research
- Vascular Procedures and Complications
- Electroconvulsive Therapy Studies
Memorial Sloan Kettering Cancer Center
2009-2018
King's College Hospital NHS Foundation Trust
2011-2017
Kings Health Partners
2012-2016
King's College Hospital
2001-2016
King's College - North Carolina
2015-2016
University of Cambridge
2001-2014
King's College London
2011-2013
West London Mental Health NHS Trust
2013
Oregon Health & Science University
2013
Florence Nightingale Foundation
2013
ABSTRACT Subcutaneous apomorphine infusion (Apo) and intrajejunal levodopa (IJLI) are two treatment options for patients with advanced Parkinson's disease (PD) refractory motor complications, varying cost of treatment. There no multicenter studies comparing the effects strategies. This open‐label, prospective, observational, 6‐month, study compared 43 on Apo (48.8% males, age 62.3 ± 10.6 years; duration: 14 4.4 median H & Y stage 3; interquartile range [IQR]: 3‐4) 44 IJLI (56.8% 62.7 9.1...
To test the effects of a novel cognitive-behavioral therapy (CBT)-based intervention delivered by nurse therapist to patients with Parkinson disease (PD) clinically significant impulse control behaviors (ICB).This was randomized controlled trial comparing up 12 sessions CBT-based compared waiting list condition standard medical care (SMC). A total 27 were and 17 list. Patients Mini-Mental State Examination score <24 excluded. The coprimary outcomes overall symptom severity neuropsychiatric...
Apomorphine infusion therapy remains under-used and there are no comparative studies of motor non-motor effects apomorphine infusion.In this paper we report preliminary results from an ongoing clinical observational "real life" surveillance-based study focused on symptoms health-related quality life in a group patients apomorphine.Apomorphine led to highly significant improvements UPDRS 3 (p = 0.0003), 4 PDQ-8 (Parkinson's disease questionnaire, p 0.001) NMSS total (non scale, 0.0003)....
Background: Palliative care is rarely being offered to patients with Parkinson’s disease. Aim: To assess symptom prevalence, severity and palliative needs in advanced stages of Parkinsonism. Design: A cross-sectional survey using a assessment tool, the Outcome Scale was administered patients. Setting/participants: Eight-two diagnosis idiopathic disease, multiple systems atrophy or progressive supranuclear palsy were included study. Results: Their mean age disease 3–5 Hoehn Yahr 67 years 4.1,...
Seventeen patients with advanced Parkinson disease (PD) were treated intrajejunal L-dopa infusion (IJL) and compared a matched group of 9 (termed comparator [C]) not given IJL because funding restriction by primary care trusts (PCTs) in the UK, although considered to be clinically eligible for IJL. Assessments baseline follow-up (6 months) Hoehn Yahr staging, unified PD rating scale (UPDRS-III UPDRS-IV), questionnaire (PDQ-8, quality life [QoL]) nonmotor symptom (NMSS).Baseline...
Cancer and Aging: Reflections for Elders (CARE) is a novel, telephone-delivered intervention designed to alleviate distress in older cancer patients. This pilot randomized controlled trial tested the feasibility initial efficacy of CARE, drawing from age-appropriate developmental themes well-established coping theory.Eligible patients were ≥70 years old; ≥6 months post-diagnosis lung, prostate, breast, lymphoma, or gynecological cancer; on active treatment within 6 ending treatment; had...
Abstract Background Impulse‐control behaviors ( ICB s) are increasingly recognized in Parkinson's disease PD ) as drug‐related effects of dopaminergic mediation that occur 15% to 35% patients with . The authors describe the design and evaluation a new, clinician‐rated severity scale for assessment syndromal subsyndromal forms impulse‐control disorders ICD s), simple (punding) complex (hobbyism) repetitive behaviors, compulsive overuse medication (dopamine dysregulation syndrome). Methods...
The aim of this study was to investigate the clinical, neuropsychological, and self-awareness correlates impulse-control disorder (ICD) in a group 17 Parkinson's disease (PD) subjects with an active ICD comparison PD without ICD. Self-awareness assessed Beck Cognitive Insight Scale patient–caregiver discrepancy scores from ratings on Dysexecutive Questionnaire Everyday Memory Questionnaire–Revised. comparable or increased those ICD, versus without, measures neuropsychological functioning did...
Background: The negative impact of wearing-off on the quality life (QoL) people with Parkinson's (PWPs) is well established. However, most studies have been performed from clinician's perspective, and needs PwPs care partners considered separately. Objective: This s urvey aimed to better understand both patient partner lives assess how often they are asked about their QoL in specialist consultations. Methods: registered Cure Trust database were invited participate an online survey consisting...
Dopamine agonist withdrawal syndrome (DAWS) has been reported in patients with Parkinson's disease (PD) who rapidly decrease or stop their dopamine (DA) treatment. Retrospective studies suggest a high prevalence of DAWS (14%-18%) PD, but there are no prospective studies. We report data from the first pilot European multicenter study addressing frequency probable (Rabinak-Nirenberg criteria) PD patients. The self-completed Nonmotor Symptoms Questionnaire (which addresses core features DAWS)...
Background The objective of this study was to investigate in vivo the ability levodopa/carbidopa intestinal gel infusions produce sustained striatal dopamine levels and improve clinical outcomes Parkinson's disease patients. Methods Six advanced patients had serial [11C]raclopride PET assess infusion-induced rises as reflected by a fall dopamine-D2/3 receptor availability. baseline scan OFF-dopaminergic stimulation 2 scans following initiation infusions. Striatal D2/3 binding measured...
Fatigue is a common yet poorly understood and underresearched nonmotor symptom in Parkinson's disease. Although fatigue recognized to significantly affect health-related quality of life, it remains underrecognised empirically treated. In this paper, the prevalence as measured by validated visual analogue scale disease symptoms (PDNMSS) was correlated with other motor comorbidities. cohort patients from range stages, occurrence closely more advanced disease, well depression, anxiety, sleep...
Elderly patients with cancer face unique physical and psychiatric challenges in coping their illness. Optimal psychosocial therapy for older requires recognizing certain enhanced psychological capacities such as better illness, which is associated age. This strength can be combined the most appropriate cognitive strategies to develop a model intervention. paper describes model, integrates Erik Erikson's eighth final developmental life stage, task achieve ego integrity (equanimity) or...
Aims: Papillary meningioma is a rare meningeal tumour. To date only few cases have been reported and their immunohistochemical features not fully documented. Methods results: A 49‐year‐old woman presented with 2‐month history of headaches memory disturbance. CT MRI imaging showed an enhancing pineal mass extension into the occipital lobes invasion splenium. At surgery, tumour was found to be tough vascular well‐defined capsule. No recurrence noted 19 months after operation. In another case...
Purpose: The experience of working for people with Parkinson's disease (PD) is known to vary substantially and affects the length time in employment after diagnosis. This study aims at exploring PD create a model detailing factors that influence their workplace success.Method: A qualitative grounded theoretical approach was used. Seventeen were selected individual interviews which conducted sequentially. Data analyzed an iterative, inductive process coding identify common themes generate...
Parkinson's is the second most common neurodegenerative disorder. Characterised by both motor and non-motor symptoms, it affects young as well old. Offering treatment with minimal disruption providing an easily accessible support network vital for quality of life people living Parkinson's, particularly younger people. King's College Hospital offers full specialist care Parkinson's. At heart this Disease Nurse Specialist (PDNS), who provides continuous within health-care setting in people's...