A5101577021- Inflammatory Bowel Disease
- Catalytic C–H Functionalization Methods
- Digestive system and related health
- Immune Response and Inflammation
- Oxidative Organic Chemistry Reactions
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Pharmacological Effects of Medicinal Plants
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Hydrogen's biological and therapeutic effects
- Chemical Synthesis and Analysis
- Cancer Research and Treatments
- Asymmetric Hydrogenation and Catalysis
- Click Chemistry and Applications
- Genomics, phytochemicals, and oxidative stress
- Genetics, Aging, and Longevity in Model Organisms
- Alkaloids: synthesis and pharmacology
- Nanoparticle-Based Drug Delivery
- Mesenchymal stem cell research
- Congenital gastrointestinal and neural anomalies
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Glycosylation and Glycoproteins Research
Huazhong University of Science and Technology
2020-2024
Union Hospital
2022-2024
Union Hospital
2020-2023
Yangzhou University
2014
Oxidative stress, caused by excessive production of reactive oxygen species (ROS), plays a crucial role in the occurrence and development ulcerative colitis (UC). We developed ROS-responsive nanoparticles (NPs) as an efficacious nanomedicine against UC with oral administration. The NPs were fabricated d-α-tocopherol polyethylene glycol succinate-b-poly(β-thioester) copolymer (TPGS-PBTE) for ROS cleavage via colitis-targeted delivery luteolin (LUT), natural flavonoid good anti-inflammation...
Compound sophorae decoction (CSD), a Chinese Herbal decoction, is frequently clinically prescribed for patients suffered from ulcerative colitis (UC) characterized by bloody diarrhea. Yet, the underlying mechanism about how this formulae works remain elusive. In present study, experimental in C57BL/6 J mice was induced oral administration of standard diets containing 3% dextran sodium sulfate (DSS), and CSD given orally treatment at same time. The clinical symptoms including stool body...
Intestinal stem cells (ISCs) are critical for the development and rapid turnover of intestinal epithelium. The regulatory effects gut microbiota their metabolites on ISCs stemness remain elusive. Fucose has been demonstrated to mediate host–microbe interactions in intestine. However, association between fucose, bacteria, remains unclear. To investigate fucose ISCs-mediated epithelial (IECs) development, we administered 4-week-old mice 4 weeks. stemness, IECs proliferation, differentiation...
Th subsets particularly T helper 17 and regulatory cells play a critical role in immune balance colonic mucosa of Inflammatory Bowel Disease. Recent studies have indicated miR-155 is overexpressed the IBD patients. Thus, whether how influences Th17/Treg cell patients worthy researching. We divided mice into four groups: oral administration 3.0 % DSS fresh drinking water for 7 days except normal group. In this period, starting from fifth day, NC antagomir group were carried out by...
The intestinal epithelial repair after injury is coordinated by stem cells (ISCs). Fucosylation catalyzed fucosyltransferase 2 (FUT2) of the epithelium beneficial to mucosal healing but poorly defined influence on ISCs. dextran sulfate sodium (DSS) and lipopolysaccharide (LPS) model were used assess role FUT2 ISCs injury. apoptosis, function, stemness analyzed using organoids from WT Fut2ΔISC (ISC-specific Fut2 knockout) mice incubated with LPS fucose. N-glycoproteomics, UEA-1...
Fut2-mediated α1,2-fucosylation is important for gut homeostasis, including the intestinal stem cell (ISC). The stemness of ISC declines with age, and aging-associated dysfunction closely related to many age-related diseases. We previously found epithelial in some aged Fut2 knockout mice. However, how affects aging still unknown. On this basis, herein study aims investigate role aging. Aging models ISC-specific mice were established. ISCs isolated proteomics N-glycoproteomics analysis....
Intestinal barrier dysfunction is a hallmark of inflammatory bowel disease (IBD). MiR-155 increased in colitis and downregulates expression hypoxia-inducible factor 1α (HIF-1α). Here, we investigated the effects miR-155 on intestinal dextran sulfate sodium (DSS)-induced colitis. We found that antagomir treatment relieved weight loss damage IBD mouse models (P < 0.05). Furthermore, electron microscopy immunofluorescence imaging showed downregulated tight junction proteins DSS-induced FG-4497,...
The recovery of the intestinal epithelial barrier is goal for curing various injurious diseases, especially IBD. However, there are limited therapeutics restoring function in stemness stem cells (ISCs) can differentiate into mature cells, thus playing a key role rapid regeneration epithelium. IL-22 secreted by CD4+ T and ILC3 was reported to maintain ISCs. Our previous study found that L-fucose significantly ameliorated DSS-induced colonic inflammation injury. In this study, we discovered...
Transition-metal ion catalyzed intramolecular dual C-H activation to construct polycyclic heteroarene skeletons is merited for its step and atom-economic advantages in organic synthesis. However, most cases, stoichiometric oxidants, elevated temperature, other harsh conditions were commonly faced this reaction, which apparently block the synthetic applications. Herein, we report a Pd(II)/LA (LA: Lewis acid) indoloquinolinone derivatives under mild with dioxygen as sole oxidant. It was found...
Pd( ii )/Lewis acid can catalyze indole olefination faster with electron-rich olefins than electron-deficient ones, and dioxygen is employed as the sole oxidant.
Direct C-H activation and functionalization offer a convenient protocol for pharmaceutical material syntheses. Although versatile mechanisms have been proposed to depict transition-metal-catalyzed activation, date, the shared key agostic hydrogen intermediate in several major has not observed yet, which apparently puzzles mechanism-based catalyst design. This work reports direct observations of this Pd(II)/Sc(III)-catalyzed acetanilides, its stability reactivity are investigated. Remarkably,...