A5060185393- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Medical Imaging and Pathology Studies
- Scheduling and Optimization Algorithms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Advanced Manufacturing and Logistics Optimization
- RNA modifications and cancer
- Liver Diseases and Immunity
- Viral Infections and Immunology Research
- RNA Research and Splicing
- Neonatal Respiratory Health Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA and protein synthesis mechanisms
- Occupational and environmental lung diseases
- Sarcoma Diagnosis and Treatment
- Respiratory viral infections research
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal Tumor Research and Treatment
- Congenital Diaphragmatic Hernia Studies
- Building Energy and Comfort Optimization
- Gut microbiota and health
- IgG4-Related and Inflammatory Diseases
- Growth Hormone and Insulin-like Growth Factors
- Virus-based gene therapy research
- Neuroendocrine Tumor Research Advances
University of California, San Diego
2016-2025
Fuzhou University
2024-2025
UC San Diego Health System
2012-2024
Emergent BioSolutions (United States)
2020-2022
University of California San Diego Medical Center
2015-2022
Michigan Medicine
2021
Chongqing Maternal and Child Health Hospital
2020
Mayo Clinic in Arizona
2019
Österreichisches Forschungsinstitut für Chemie und Technik
2019
Institute for Information Industry
2012-2015
Retrospective studies have shown that two-dimensional magnetic resonance elastography (2D-MRE), a novel MR method for assessment of liver stiffness, correlates with advanced fibrosis in patients nonalcoholic fatty disease (NAFLD). Prospective data on diagnostic accuracy 2D-MRE the detection NAFLD are needed. The aim this study is to prospectively assess 2D-MRE, noninvasive imaging biomarker, predicting (stage 3 or 4) well-characterized biopsy-proven NAFLD. This cross-sectional analysis...
Ezetimibe inhibits intestinal cholesterol absorption and lowers low-density lipoprotein cholesterol. Uncontrolled studies have suggested that it reduces liver fat as estimated by ultrasound in nonalcoholic steatohepatitis (NASH). Therefore, we aimed to examine the efficacy of ezetimibe versus placebo reducing magnetic resonance imaging-derived proton density-fat fraction (MRI-PDFF) histology patients with biopsy-proven NASH. In this randomized, double-blind, placebo-controlled trial, 50 NASH...
OBJECTIVES: Recent studies show two-dimensional (2D)-magnetic resonance elastography (MRE) is accurate in diagnosing advanced fibrosis (stages 3 and 4) nonalcoholic fatty liver disease (NAFLD) patients. Three-dimensional (3D)-MRE a more version of the technology that can image shear-wave fields 3D entire liver. The aim this study was to prospectively compare diagnostic accuracy 3D-MRE 2D-MRE for patients with biopsy-proven NAFLD. METHODS: This cross-sectional analysis prospective included...
SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage in lungs setting of an overzealous immune response whose origin remains unclear.We present a scalable, propagable, personalized, cost-effective adult stem cell-derived human lung organoid model that is complete with both proximal and distal airway epithelia. Monolayers derived from organoids (ALOs), primary cells, or hiPSC-derived alveolar type II (AT2) pneumocytes were infected SARS-CoV-2 to create vitro models...
In this paper, we present a generic framework for controlling the work flow in computer controlled manufacturing systems. Based on market-like model and combination of objective price mechanism, allows heterogeneous job objectives, admits priorities, recognizes multiple resources types, step negotiation between parts resources. The is designed to accommodate frequent changes environment such as machine failures, tool shortages, process requirement variations. An object-oriented simulation...
ATP-dependent chromatin remodeling by the CHD family of proteins plays an important role in regulation gene transcription. Here we report that full-length CHD8 interacts directly with beta-catenin and is also recruited specifically to promoter regions several beta-catenin-responsive genes. Our results indicate negatively regulates beta-catenin-targeted expression, since short hairpin RNA against activation target This conserved through evolution; interference kismet, apparent Drosophila...
Abstract BACKGROUND: The distinction of benign from malignant mesothelial proliferations in cytologic specimens can be problematic. In this study, the authors investigated utility immunohistochemical (IHC) markers making distinction. METHODS: Archival paraffin‐embedded cell blocks pleural and peritoneal fluids 52 patients with meothelioma (MM) 64 reactive hyperplasia (MH) were retrieved. IHC stains included desmin, epithelial membrane antigen (EMA), glucose‐transport protein 1 (GLUT‐1),...
A Pilot Comparative Study of Quantitative Ultrasound, Conventional and MRI for Predicting Histology-Determined Steatosis Grade in Adult Nonalcoholic Fatty Liver DiseaseJeremy S. Paige1, Gregory Bernstein1, Elhamy Heba1, Eduardo A. C. Costa1, Marilia Fereirra1, Tanya Wolfson1,2, Anthony Gamst1,2, Mark Valasek3, Grace Y. Lin3, Aiguo Han4, John W. Erdman, Jr.5, William D. O'Brien, Jr.4, Michael P. Andre1,6, Rohit Loomba7,8 Claude B. Sirlin1Audio Available | Share Claim CREDIT
Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by a fibrotic thrombus persisting and obliterating the lumen of arteries; its pathogenesis remains poorly defined. This study investigates potential contribution for progenitor cell types in development vascular obliteration remodeling CTEPH patients. Endarterectomized tissue from patients undergoing thromboendarterectomy was collected examined structure cellular composition. Our data show an organized fibrin network...
Malignant mesothelioma (MM) arises from mesothelial cells that line the pleural, peritoneal and pericardial surfaces. The majority of MMs are pleural have been associated with asbestos exposure. Previously, genetically characterized by loss BAP1 (40-60%) as well NF2 (75%) CDKN2A (60%). rare form MM occurs in ~10% cases. With only ~300 cases diagnosed US per year, its link to exposure is not clear mutational landscape unknown.We analyzed somatic 12 epitheloid subtype using copy number...
ABSTRACT Infection of cells by many viruses affects the cell division cycle host to favor viral replication. We examined ability paramyxovirus simian parainfluenza virus 5 (SV5) affect progression, and we found that SV5 slows rate proliferation HeLa T4 cells. The SV5-infected had a delayed transition from G 1 S phase prolonged progression through phase, some infected were arrested in 2 or M phase. levels p53 p21 CIP1 not increased compared mock-infected cells, suggesting changes occur...
The IBM Supply Chain Simulator (SCS) is a software tool that can help company or group of companies make strategic business decisions about the design and operation its supply chain. SCS predecessors were originally developed by Research to improve IBM's internal chains. has played an important role in resurgence over last six years (1992-8). In 1997 Industry Solution Units began using clients their After year business, successful engagements have been completed variety geographies segments....
Factors contributing to the development of a fibrotic vascular scar and pulmonary remodeling leading chronic thromboembolic hypertension (CTEPH) are still unknown. This study investigates potential contribution multipotent progenitor cells myofibroblasts progression CTEPH. Histological examination endarterectomized tissues from patients with CTEPH identified significant neointimal formation. Morphological heterogeneity was observed in isolated these tissues, including network-like growth...
Pulmonary veno-occlusive disease is caused by excessive cell proliferation and fibrosis, which obliterate the lumen of pulmonary venules, leading to hypertension, right ventricular failure, death. This condition has no effective treatment a 5-year survival <5%. Understanding mechanism this designing therapies are urgently needed.We show that mice with homozygous deletion Ets transcription factor Erg die between embryonic day 16.5 3 months age as result disease, capillary hemorrhage,...
Surveillance donor-specific antibody (DSA) and pathologic antibody-mediated rejection (pAMR) testing is recommended in the first year after heart transplantation (HTx) adult patients. Whether pAMR adds prognostic information to contemporary DSA has not been fully studied. This was a single-center study of consecutive endomyocardial biopsies (EMB) performed between November 2010 February 2023 HTx The primary objective evaluate whether contributes additional better predict overall survival....
Abstract Deep learning technology is increasingly used in the field of power system fault detection and diagnosis, its powerful feature capability makes it play an important role intelligent process control. In this paper, we propose a method for high resistance systems design CNN-Attention-LSTM diagnosis model using various deep models such as convolutional neural network. The training simulation experiments are carried out on collected dataset. accuracy, reliability security proposed phase...
Cancer genetics studies have dramatically advanced the understanding of molecular drivers in various types neoplasms. This progress is also leading to discovery more new agents block those drivers, which has significantly improved cancer patient survival, especially non-small cell lung (NSCLC). However, about 25% NSCLC tumors are not yet known. Herein, we present a poorly differentiated carcinoma involving and mediastinum. Next generation sequencing-based RNAseq identified novel fusion,...
ABSTRACT In some cell types the paramyxovirus simian virus 5 (SV5) causes little cytopathic effect (CPE) and infection continues productively for long periods of time; e.g., SV5 can be produced from MDBK cells up to 40 days with CPE. differs most paramyxoviruses in that it encodes a small (44-amino-acid) hydrophobic integral membrane protein (SH). When were infected recombinant containing deletion SH gene (rSV5ΔSH), exhibited an increase CPE compared wild-type (recovered cDNA; rSV5). The...