A5028710077- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune responses and vaccinations
- Inflammatory Bowel Disease
- Single-cell and spatial transcriptomics
- Immunodeficiency and Autoimmune Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Reproductive Biology and Fertility
- Inflammatory Myopathies and Dermatomyositis
- SARS-CoV-2 and COVID-19 Research
- Sperm and Testicular Function
- Hemoglobinopathies and Related Disorders
- Dental Research and COVID-19
- Plant Stress Responses and Tolerance
- Caveolin-1 and cellular processes
- Layered Double Hydroxides Synthesis and Applications
- Neural Networks and Reservoir Computing
- Scientific and Engineering Research Topics
University of California, San Diego
2020-2025
Jacobs (United States)
2020-2024
Shiraz University
2024
San Diego Supercomputer Center
2021-2022
Yasouj University
2022
Shenandoah University
2022
University of Technology Malaysia
2020-2021
Rady Children's Hospital-San Diego
2020
Islamic Azad University, Damghan Branch
2020
Weill Cornell Medical College in Qatar
2020
SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage in lungs setting of an overzealous immune response whose origin remains unclear.We present a scalable, propagable, personalized, cost-effective adult stem cell-derived human lung organoid model that is complete with both proximal and distal airway epithelia. Monolayers derived from organoids (ALOs), primary cells, or hiPSC-derived alveolar type II (AT2) pneumocytes were infected SARS-CoV-2 to create vitro models...
BackgroundSingle-cell transcriptomic studies have greatly improved organ-specific insights into macrophage polarization states are essential for the initiation and resolution of inflammation in all tissues; however, such yet to translate therapies that can predictably alter fate.MethodUsing machine learning algorithms on human macrophages, here we reveal continuum is shared across diverse contexts. A path, comprised 338 genes accurately identified both physiologic pathologic spectra...
Coronavirus Disease 2019 (Covid-19) continues to challenge the limits of our knowledge and healthcare system. Here we sought define host immune response, a.k.a, "cytokine storm" that has been implicated in fatal COVID-19 using an AI-based approach.
Macrophages engulf and digest microbes, cellular debris, various disease-associated cells throughout the body. Understanding dynamics of macrophage gene expression is crucial for studying human diseases. As both bulk RNAseq single cell datasets become more numerous complex, identifying a universal reliable marker becomes paramount. Traditional approaches have relied upon tissue specific patterns. To identify biomarkers macrophage, we used previously published computational approach called...
Summary SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage in lungs setting of an overzealous immune response whose origin remains unclear. We present a scalable, propagable, personalized, cost-effective adult stem cell-derived human lung organoid model that is complete with both proximal and distal airway epithelia. Monolayers derived from organoids (ALOs), primary cells, or hiPSC-derived alveolar type-II (AT2) pneumocytes were infected SARS-CoV-2 to create vitro...
Abstract Lung macrophages mature after birth, placing newborn infants, particularly those born preterm, within a unique window of susceptibility to disease. We hypothesized that in preterm lung macrophage immaturity contributes the development bronchopulmonary dysplasia (BPD), most common serious complication prematurity. By measuring changes gene expression patients at risk BPD, we show here eventually developing BPD had higher inflammatory mediator even on first day life. Surprisingly, ex...
Crohn's disease (CD) is a complex, clinically heterogeneous of multifactorial origin; there no perfect pre-clinical model, little insight into the basis for such heterogeneity, and still cure. To address these unmet needs, we sought to explore translational potential adult stem cell-derived organoids that not only retain their tissue identity, but also genetic epigenetic disease-driving traits. We prospectively created biobank CD patient-derived organoid cultures (PDOs) using biopsied...
We sought to define the host immune response, a.k.a, "cytokine storm" that has been implicated in fatal COVID-19 using an AI-based approach. Over 45,000 transcriptomic datasets of viral pandemics were analyzed extract a 166-gene signature ACE2 as 'seed' gene; was rationalized because it encodes receptor facilitates entry SARS-CoV-2 (the virus causes COVID-19) into cells. Surprisingly, this conserved all vi ral p andemics, including COVID-19, and subset 20-genes classified disease severity,...
Background: Probiotics are living bacteria, which can be used as a food supplement to produce inhibitory agents and compete with pathogens in the guts. Nowadays, because of easy accessibility misuse antibiotics, probiotic usage is increasing. The goal our study assess effects probiotics on colorectal surgery complications.
 Methods: enrolled cases were selected from candidate patients, who referred Sina Imam Reza Hospitals Tabriz University April 2016 2017. They divided into two groups...
Personality is the fundamental thing that forms behavioral tendencies of each individuality in a situation. A common model used to describe personality big five divides traits into dimensions neuroticism, extraversion, openness, agreeableness, and conscientiousness. assessment through physiological signals offers objectivity reliability test results due minimal role takers examination process. One widely recommended approach signal-based analysis electroencephalography (EEG). The EEG signal...
For a sperm to successfully fertilize an egg, it must first undergo capacitation in the female reproductive tract and later acrosomal reaction (AR) upon encountering egg surrounded by its vestment. How premature AR is avoided despite rapid surges signaling cascades during remains unknown. Using combination of conditional knockout (cKO) mice cell-penetrating peptides, we show that GIV (CCDC88A), guanine nucleotide-exchange modulator (GEM) for trimeric GTPases, highly expressed spermatocytes...
Background:Anti-MDA5 (Melanoma differentiation-associated protein-5) positive dermatomyositis (MDA5+-DM) is characterised by rapidly progressive interstitial lung disease (ILD) and high mortality. MDA5 senses single-stranded RNA a key pattern recognition receptor for the SARS-CoV-2 virus.Methods: This retrospective observational study of surge in autoimmunity, as determined using 15 muscle-specific autoantibodies (MSAs) panel, between Janurary 2018-December 2022 Yorkshire, UK....
Most deep learning accelerators in the literature focus only on improving design of inference phase. We propose a novel photonics-based backpropagation accelerator for high performance training. The proposed MEMTONIC architecture is first-of-its-kind memristor-integrated end-to-end training and prediction. evaluate using photonic CAD framework (IPKISS) benchmark models including LeNet VGG-Net. achieves at least 35× acceleration time, 31× improvement computational efficiency, 45× energy...
Abstract Since the pandemic spread of COVID-19, it has posed a unique public health concern worldwide due to its increased death rate all around world. The disease is caused by SARS-CoV-2, which main cause Middle East Respiratory Syndrome (MERS) and severe acute respiratory syndrome (SARS). Risk assessment vital action toward risk reduction as increases understanding factors associated with allows existing data decide on adequate preventive mitigation measures. Machine learning techniques...
Abstract Single-cell transcriptomic studies have greatly improved organ-specific insights into macrophage polarization states are essential for the initiation and resolution of inflammation in all tissues; however, such yet to translate therapies that can predictably alter fate. Using machine learning algorithms on human macrophages, here we reveal continuum is shared across diverse contexts. A path, comprised 338 genes accurately identified both physiologic pathologic spectra “ reactivity ”...