A5088605057- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pleural and Pulmonary Diseases
- Ethics in medical practice
- Palliative Care and End-of-Life Issues
- Airway Management and Intubation Techniques
- Organ Donation and Transplantation
- Tracheal and airway disorders
- Family and Patient Care in Intensive Care Units
- Patient Dignity and Privacy
- Religion, Spirituality, and Psychology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Intensive Care Unit Cognitive Disorders
- Congenital Diaphragmatic Hernia Studies
- Medical Imaging and Pathology Studies
- Transplantation: Methods and Outcomes
- Biblical Studies and Interpretation
- Obstructive Sleep Apnea Research
- Esophageal and GI Pathology
- Organ Transplantation Techniques and Outcomes
- American Constitutional Law and Politics
- Lung Cancer Diagnosis and Treatment
- Organ and Tissue Transplantation Research
- Delphi Technique in Research
- Asthma and respiratory diseases
Temple University
2004-2019
Heidelberg University
2019
Temple University Hospital
2004-2018
Archdiocese of Chicago
2018
Worcester Memorial Hospital
2012
St Vincent Hospital
2012
Philadelphia University
1996
Einstein Medical Center Philadelphia
1996
University of Maryland, Baltimore
1991-1995
University of Maryland Medical Center
1991
Rationale: This is the first multicenter randomized controlled trial to evaluate effectiveness and safety of Zephyr Endobronchial Valve (EBV) in patients with little no collateral ventilation out 12 months.Objectives: To EBV heterogeneous emphysema treated lobe.Methods: Subjects were enrolled a 2:1 randomization (EBV/standard care [SoC]) at 24 sites. Primary outcome months was ΔEBV–SoC subjects post-bronchodilator FEV1 improvement from baseline greater than or equal 15%. Secondary endpoints...
Several uncontrolled studies report improvement in lung function, gas exchange, and exercise capacity after bilateral volume reduction surgery (LVRS). We recruited 200 patients with severe chronic obstructive pulmonary disease (COPD) for a prospective randomized trial of rehabilitation versus LVRS stapling resection 20 to 40% each lung. Pulmonary function tests, 6-min walk distance, symptom-limited maximal testing were done all at baseline 8 wk rehabilitation. Patients then either 3...
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Free radical injury is believed to be important in diaphragm dysfunction. N-Acetylcysteine (NAC) a potent free scavenger shown animal models attenuate fatigue; however, its effects on human function are unknown. We assessed by electrophrenic twitch stimulation (PdiT) and occlusion (to yield Pdimax) four healthy subjects 35 ± 3 yr of age (mean SD). intravenously administered NAC (150 mg/kg 250 ml D5W) or placebo (CON) (250 randomized manner after were premedicated with antihistamines. There...
Since lung volume reduction surgery (LVRS) reduces end-expiratory volume, we hypothesized that it may improve diaphragm strength. We evaluated 37 patients for pulmonary rehabilitation and LVRS. Before 8 wk after rehabilitation, 24 had spirometry, volumes, diffusion capacity, incremental symptom limited maximum exercise test, 6-min walk maximal static inspiratory expiratory mouth pressures, transdiaphragmatic pressures during efforts bilateral supramaximal electrophrenic twitch stimulation...
Lung volume reduction surgery (LVRS) has been suggested as improving respiratory mechanics in patients with severe chronic obstructive pulmonary disease (COPD). We hypothesized that LVRS might lengthen the diaphragm, increase its area of apposition chest wall, and thereby improve mechanical function. To determine effect bilateral on diaphragm length, we measured length at TLC, using plain roentgenograms (CXRs), 25 (11 males 14 females) before 3 to 6 mo after LVRS. A subgroup seven (reference...
This article is a complement to “A Template for Non-Religious-Based Discussions Against Euthanasia” by Melissa Harintho, Nathaniel Bloodworth, and E. Wesley Ely which appeared in the February 2015 Linacre Quarterly. Herein we build upon Daniel Sulmasy's opening closing arguments from 2014 Intelligence Squared debate on legalizing assisted suicide, supplemented other non-faith-based thoughts, providing four nontheistic against physician-assisted suicide euthanasia: (1) “it offends me”; (2)...
Rationale: Bronchoscopic lung volume reduction with Zephyr Valves improves function, exercise tolerance, and quality of life patients hyperinflated emphysema little to no collateral ventilation.Objectives:Post hoc analysis patient-reported outcomes (PROs), including multidimensional measures dyspnea, activity, life, in the LIBERATE (Lung Function Improvement after Lung Volume Reduction Pulmonx Endobronchial used Treatment Emphysema) study are reported.Methods: A total 190 severe...
Patients with severe chronic obstructive pulmonary disease (COPD) have varying degrees of hypercapnia. Recent studies demonstrated inconsistent effects lung volume reduction surgery (LVRS) on PaCO2 ; however, most series excluded patients moderate to In addition, no study has examined the mechanisms responsible for in post-LVRS. We obtained spirometry, body plethysmography, diffusion capacity, respiratory muscle strength, 6-min walk test, and incremental symptom-limited maximal exercise data...
Alveolar adenomas are extremely rare, benign, primary lung tumors of unknown histogenesis that characterized by proliferative type II alveolar epithelium and septal mesenchyma. Mostly incidental, they clinically important as can imitate benign secondary malignant at times difficult to differentiate from early-stage cancer. We describe the case a 59-year-old man with an incidental microscopic adenoma coexisting poorly differentiated carcinoma.A Caucasian medical history smoking chronic...
Low frequency diaphragm fatigue (LFF) may play a major role in the pathogenesis of ventilatory failure; however, recovery from LFF is not well studied. We measured transdiaphragmatic twitch pressure (PdiT) at FRC (using reduction PdiT as an index LFF) and maximum (Pdimax) before after induction seven normal subjects, age 31 ± 3 yr (mean SD). Fatigue was induced by breathing through inspiratory resistive load. produced bilateral transcutaneous supramaximal electrophrenic stimulation baseline,...