A5062192619- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Advances in Oncology and Radiotherapy
- Extracellular vesicles in disease
- Health Sciences Research and Education
- Pediatric health and respiratory diseases
- Global Cancer Incidence and Screening
- Head and Neck Anomalies
- Pleural and Pulmonary Diseases
- Clinical Nutrition and Gastroenterology
- Pneumocystis jirovecii pneumonia detection and treatment
- Obstructive Sleep Apnea Research
- Inhalation and Respiratory Drug Delivery
- Hemoglobinopathies and Related Disorders
- Tracheal and airway disorders
- Respiratory and Cough-Related Research
- Delphi Technique in Research
- Electrolyte and hormonal disorders
- Asthma and respiratory diseases
- Ultrasound in Clinical Applications
- Palliative Care and End-of-Life Issues
Royal Free London NHS Foundation Trust
2024-2025
Assiut University
2019-2024
Royal Brompton Hospital
2018-2020
Chelsea and Westminster Hospital
2020
Royal Brompton & Harefield NHS Foundation Trust
2019
Imperial College London
2018-2019
Rationale: This is the first multicenter randomized controlled trial to evaluate effectiveness and safety of Zephyr Endobronchial Valve (EBV) in patients with little no collateral ventilation out 12 months.Objectives: To EBV heterogeneous emphysema treated lobe.Methods: Subjects were enrolled a 2:1 randomization (EBV/standard care [SoC]) at 24 sites. Primary outcome months was ΔEBV–SoC subjects post-bronchodilator FEV1 improvement from baseline greater than or equal 15%. Secondary endpoints...
<title>Extract</title> COPD causes significant morbidity and mortality – it is the fourth leading cause of death worldwide(1) there urgent need to develop test new therapeutics. Barriers recruitment into clinical trials include complex equipment technical specifications for spirometry imaging, 'clinical stability' in a target population with high risk exacerbations separation trial expertise from usual patient care(2). Strategies improve are therefore required.
Rationale: Bronchoscopic lung volume reduction with Zephyr Valves improves function, exercise tolerance, and quality of life patients hyperinflated emphysema little to no collateral ventilation.Objectives:Post hoc analysis patient-reported outcomes (PROs), including multidimensional measures dyspnea, activity, life, in the LIBERATE (Lung Function Improvement after Lung Volume Reduction Pulmonx Endobronchial used Treatment Emphysema) study are reported.Methods: A total 190 severe...
Despite advances in the pathophysiology of chronic obstructive pulmonary disease (COPD), there is a distinct lack biochemical markers to aid clinical management. Microvesicles (MVs) have been implicated inflammatory diseases including COPD, but their association COPD severity remains unknown. We analyzed different MV populations plasma and bronchoalveolar lavage fluid (BALF) taken from 62 patients with mild very severe (51% male; mean age: 65.9 yr). These underwent comprehensive evaluation...
Recent advances in bronchoscopic lung volume reduction offer new therapies for patients with emphysema and hyperinflation. Pulmonary lobe segmentation quantification of lobar volumes severity plays a pivotal role treatment planning post-interventional assessment. Computed tomography (CT)-derived could reflect more accurate regional changes pulmonary function.The aim our study is to validate the reliability an in-house CT Lung Segmentation software (LungSeg; Hamlyn Centre, Imperial College...
<b>Background:</b> Endobronchial Ultrasound guidance allows lymph nodes in the mediastinum to be sampled under direct vision. The currently available EBUS-TBNA needles usually provide adequate samples for cytological assessment, but do not always contain sufficient material preparation of a cell block, thereby precluding histological assessment. Larger core tissue biopsy specimens are more likely establish diagnosis suspected lung cancer patients. It can also improve diagnostic yield...
<h3>Introduction</h3> Clinical trial recruitment in COPD is challenging for multiple reasons, including mismatch between location of care and clinical expertise. Lung Cancer Screening (LCS) offers a way reaching more patients who are already showing willingness to engage with healthcare. We report the response rate characteristics individuals self-reported invited an interventional through LCS. <h3>Methods</h3> The SUMMIT LCS study (NCT03934866) used screening questionnaire determine lung...
<b>Background:</b> Microvesicles (MV) play an important role in mediating intra-alveolar inflammation during acute lung injury (Soni et al. Thorax 2016). We investigated the profile of MVs present within bronchoalveolar lavage fluid (BALF) and plasma patients with another inflammatory disease, COPD, assessed relationship to disease severity. <b>Methods:</b> Moderate severe COPD (n=30) underwent clinical evaluation (symptom scores, function, exercise testing) bronchoscopy. Paired plasma/BALF...
Abstract Background Sixty moderate diseased COVID-19 patients were divided into two equal groups and enrolled in a randomized double - blind clinical trial. Group C was delivered standard enteral nutrition plus 100 ml/day of 0.9% normal saline. L fish-oil-based lipid emulsion (FOBLE) supplementation to at dose ml/day. Both infused rate 12.5 ml/h over 8 h for 5 days. We aimed compare the effect FOBLE versus placebo disease clarify impact on number shifted ICU, oxygenation, inflammatory...
<b>Rationale:</b> Conventional ventilation/perfusion (V̇A/Q) scan is currently used to identify the target lobe for lung volume reduction (LVR) in patients with emphysema. <b>Methods:</b> We aimed assess agreement between conventional V̇A/Q and quantitative computed tomography (QCT) estimating lobar V̇A perfusion 53 emphysema, candidate LVR. The LungSeg software was estimate vessel on QCT. <b>Results:</b> There were no significant differences QCT [RUL (-2.1%(-21.5-17.2)), mean difference...