A5002519253- Glutathione Transferases and Polymorphisms
- Catalysis and Oxidation Reactions
- Genomics, phytochemicals, and oxidative stress
- Catalytic Processes in Materials Science
- Pharmacogenetics and Drug Metabolism
- Multiple Myeloma Research and Treatments
- Peripheral Neuropathies and Disorders
- Infection Control and Ventilation
- Pregnancy and Medication Impact
- Cardiovascular Health and Disease Prevention
- Polyoxometalates: Synthesis and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Cerebral Venous Sinus Thrombosis
- Infectious Diseases and Mycology
- Pediatric Urology and Nephrology Studies
- Pediatric Hepatobiliary Diseases and Treatments
- COVID-19 epidemiological studies
- Renal function and acid-base balance
- Neurological Disease Mechanisms and Treatments
- Copper-based nanomaterials and applications
- Chronic Kidney Disease and Diabetes
- COVID-19 Impact on Reproduction
- Odor and Emission Control Technologies
- Sulfur Compounds in Biology
- Barrier Structure and Function Studies
University of Bologna
2022-2024
Azienda USL di Bologna
2021-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2023
University of Chieti-Pescara
2003-2018
University of Rome Tor Vergata
2008-2015
Zero to Three
2010
University of Udine
1996-2000
Istituto Nazionale per la Fisica della Materia
1999
Public Risk Management Association
1979
Acquired drug resistance was found to be suppressed in the doxorubicin-resistant breast cancer cell line MCF7/Dx after pre-treatment with GSNO (nitrosoglutathione). The effect accompanied by enhanced protein glutathionylation and accumulation of doxorubicin nucleus. Among glutathionylated proteins, we identified three members histone family; this is, our knowledge, first time that has been reported. Formation potential NO donor dinitrosyl-diglutathionyl-iron complex, bound GSTP1-1...
The room-temperature high energy ball-milling technique was used to prepare nanophase Ce1-xZrxO2 (x=0; 0.2; 0.5; 0.8; 1) catalysts. acid–base properties of these catalysts were investigated by means adsorption microcalorimetry, using NH3 and CO2 as probe molecules. catalytic activity for 4-methylpentan-2-ol dehydration tested at atmospheric pressure in a fixed-bed flow microreactor. inclusion increasingly contents zirconium into the ceria lattice has complex influence on acidity basicity...
The aim of the present study was to evaluate serum and urinary nitric oxide (NO) concentrations in children adolescents with diabetes compared age-matched healthy control subjects find out whether Doppler ultrasonography could be used detect changes renal resistive indexes (RIs) assess there are correlations between these parameters NO excretion.We studied 42 type 1 41 matched subjects, both divided into prepubertal or pubertal children. Serum nitrite nitrate (NO2-+NO3-) were evaluated as an...
Abstract We evaluated glutathione transferase (GST) activities and the levels of glutathionylated hemoglobin in RBC 42 workers exposed to 1,3-butadiene a petrochemical plant, using 43 not 82 foresters as internal external controls, respectively. Median exposure were 1.5, 0.4, 0.1 μg/m3 1,3-butadiene-exposed workers, directly 1,3-butadiene, foresters, In addition, we determined peripheral blood lymphocytes same individuals presence GST polymorphic genes GSTT1 GSTM1 distribution GSTP1 allelic...
To assay the presence of SARS-CoV-2 genome in vaginal, rectal, and placental swabs among pregnant women newborn nasopharyngeal to investigate immunological response maternal antibody transfer through umbilical cord blood milk unvaccinated mothers.Vaginal, specimens, neonatal serum, were collected from a wide cohort Italian with confirmed infection admitted hospital between February 25, 2020 June 30, 2021. Samples tested selected reference laboratories according shared interlaboratory...
Although clinically evident diabetes-related microvascular complications are extremely rare in childhood, early functional and structural abnormalities may be present a few years after the onset of disease. Renal Doppler resistance index (RI) is widely used for evaluation blood flow renal parenchymal diseases. This study was designed to investigate possible alteration intrarenal RI children with diabetes compared healthy children.The performed 42 (age range, 6-18 years) 41 age-matched...
The effect of the Y108V mutation human glutathione S-transferase P1-1 (hGST P1-1) on binding diuretic drug ethacrynic acid (EA) and its conjugate (EASG) was investigated by calorimetric, spectrofluorimetric, crystallographic studies. Tyr 108 --> Val resulted in a 3D-structure very similar to wild type (wt) enzyme, where both hydrophobic ligand site (H-site) (G-site) are unchanged except for itself. However, due slight increase hydrophobicity H-site, as consequence mutation, an entropy...
Corticosteroids are commonly used in the treatment of stroke, although their clinical effectiveness has not been established. Side effects, especially gastrointestinal complications, occur patients with cerebral disease. A necroscopy study 124 investigated occurrence lesions acute stroke treated high-dose corticosteroids compared to untreated and dying from non-vascular neurological diseases. significant relationship between use steroids lesion strokes is demonstrated.
The diuretic drug ethacrynic acid (EA), both an inhibitor and substrate of pi class glutathione S-transferase (GST P1-1), has been tested in clinical trials as adjuvant chemotherapy. We recently studied the role active site residue Tyr-108 binding EA to enzyme found that analysis was complicated by covalent this highly reactive Cys-47. Previous attempts eliminate chemical modification yielded ambiguous results therefore we decided here produce a double mutant C47S/Y108V directed mutagenesis...
Abstract Human glutathione S‐transferase P1‐1 (hGST P1‐1) is involved in cell detoxification processes through the conjugation of its natural substrate, reduced (GSH), with xenobiotics. GSTs are known to be overexpressed tumors, and naturally occurring isothiocyanates, such as benzyl isothiocyanate (BITC), effective cancer chemopreventive compounds. To identify characterize potential inhibitory mechanisms GST induced by conjugates, we studied binding some cysteine mutants BITC–SG conjugate...
Environmental contamination by SARS-CoV-2 from patients with COVID-19 undergoing noninvasive ventilation (NIV) in the ICU is still under investigation. This study set out to investigate presence of on surfaces near subjects receiving NIV controlled conditions (ie, use dual-limb circuits, filters, adequate room ventilation).
Mycobacterium chimaera, belonging to the avium complex, is an opportunistic environmental mycobacterium which has been isolated from medical device water samples such as Heater Cooler Units (HCU). Laboratories currently use culture-based diagnostic methods detect M. but these take a long time obtain results. The aim of this study test and define Limit Detection (LoD) Real-Time Polymerase Chain Reaction (RT-PCR) specific for using sample-to-result InGenius platform, performed on collected at...