A5082951347- Cellular Mechanics and Interactions
- Genetics and Neurodevelopmental Disorders
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Cell Adhesion Molecules Research
- Glycogen Storage Diseases and Myoclonus
- 14-3-3 protein interactions
- Wnt/β-catenin signaling in development and cancer
- Marine Biology and Environmental Chemistry
- Protist diversity and phylogeny
- Axon Guidance and Neuronal Signaling
- Thermoelastic and Magnetoelastic Phenomena
- Spaceflight effects on biology
- Ultrasound and Hyperthermia Applications
- Protein Degradation and Inhibitors
- HER2/EGFR in Cancer Research
- Marine Invertebrate Physiology and Ecology
- Magnetic and Electromagnetic Effects
- Metabolism, Diabetes, and Cancer
Inserm
2015-2024
Sorbonne Université
2022-2024
Institut Curie
2015-2024
Université Paris Sciences et Lettres
2015-2024
Physique des Cellules et Cancers
2015-2022
Centre National de la Recherche Scientifique
2010-2022
MRC Protein Phosphorylation and Ubiquitylation Unit
2016
University of Dundee
2009-2016
Institut Pasteur
2006-2010
Centro de Investigaciones Biológicas Margarita Salas
2007
Lafora progressive myoclonus epilepsy (LD) is a fatal autosomal recessive neurodegenerative disorder characterized by the presence of glycogen-like intracellular inclusions called bodies. LD caused mutations in two genes, EPM2A and EPM2B, encoding respectively laforin, dual-specificity protein phosphatase, malin, an E3 ubiquitin ligase. Previously, we others have suggested that interactions between laforin PTG (a regulatory subunit type 1 phosphatase) malin are critical pathogenesis LD....
The creation of translation-competent mRNA is dependent on RNA polymerase II transcripts being modified by addition the 7-methylguanosine (m7G) cap. factors that mediate splicing, nuclear export, and translation initiation are recruited to transcript via cap structure formed several activities completed RNMT (RNA guanine-7 methyltransferase), which catalyzes N7 methylation guanosine. We report CDK1-cyclin B1 phosphorylates regulatory domain T77 during G2/M phase cell cycle. phosphorylation...
The COP9 signalosome (CSN) is a conserved, multisubunit complex first identified as developmental regulator in plants. Gene inactivation of single CSN subunits results early embryonic lethality mice, indicating that the essential for mammalian development. pleiotropic function may be related to its ability remove ubiquitin-like peptide Nedd8 from cullin-RING ubiquitin ligases, such SCF complex, and therefore regulate their activity. However, mechanism regulatory action on cullins has been...
The c-Myc proto-oncogene promotes mRNA cap methylation, which is essential for almost all translation. methylation reaction produces an inhibitory byproduct, S-adenosyl homocysteine. Here we report that Myc upregulation of homocysteine hydrolase (SAHH), enzyme hydrolyzes homocysteine, thus neutralizing its effects, and this required c-Myc-induced methylation. was repressed by inhibiting the expression or activity SAHH, whereas same treatments did not have a significant effect on...
Abstract How mechanical stress actively impacts the physiology and pathophysiology of cells tissues is little investigated in vivo. The colon constantly submitted to multi-frequency spontaneous pulsatile waves, which highest frequency functions, 2 s period, remain poorly understood. Here we find vivo that high stresses maintain physiological level mice stem (SC) through mechanosensitive Ret kinase. When permanently stimulated by a magnetic mimicking-tumor growth analogue pressure, SC levels...
The evolutionary emergence of the primitive gut in Metazoa is one decisive events that conditioned major transition, leading to origin animal development. It thought have been induced by specification endomesoderm (EM) into multicellular tissue and its invagination (i.e., gastrulation). However, biochemical signals underlying EM gastrulation remain unknown. Herein, we find hydrodynamic mechanical strains, reminiscent soft marine flow, trigger active invagination/gastrulation or curvature...