A5064867696- Ultrasound Imaging and Elastography
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Hyperthermia Applications
- Advanced MRI Techniques and Applications
- Neonatal and fetal brain pathology
- Neural dynamics and brain function
- Medical Image Segmentation Techniques
- Electrical and Bioimpedance Tomography
- Optical Imaging and Spectroscopy Techniques
- Neuroscience and Neural Engineering
- Ultrasonics and Acoustic Wave Propagation
- EEG and Brain-Computer Interfaces
- Neonatal Respiratory Health Research
- Cell Image Analysis Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Speech and Audio Processing
- Cellular Mechanics and Interactions
- Cardiac Arrest and Resuscitation
- Thermal Regulation in Medicine
- Neuroscience and Music Perception
- Hearing Loss and Rehabilitation
- Heart Rate Variability and Autonomic Control
- Barrier Structure and Function Studies
- Thermoelastic and Magnetoelastic Phenomena
- Birth, Development, and Health
ESPCI Paris
2016-2025
Centre National de la Recherche Scientifique
2016-2025
Université Paris Sciences et Lettres
2015-2025
Inserm
2016-2025
Physique pour la médecine Paris
2019-2024
ParisTech
2014-2022
Institut Langevin
2014-2020
Université Paris Cité
2015-2020
Institut Jean Nicod
2018
PremUP
2015
Ultrafast ultrasonic imaging is a rapidly developing field based on the unfocused transmission of plane or diverging ultrasound waves. This recent approach to leads large increase in raw data available per acquisition. Bigger synchronous datasets can be exploited order strongly improve discrimination between tissue and blood motion Doppler imaging. Here we propose spatiotemporal singular value decomposition clutter rejection acquired at ultrafast frame rate. The (SVD) takes benefits...
Singular value decomposition of ultrafast imaging ultrasonic data sets has recently been shown to build a vector basis far more adapted the discrimination tissue and blood flow than classical Fourier basis, improving by large factor clutter filtering estimation. However, question optimally estimating boundary between subspace remained unanswered. Here, we introduce an efficient estimator for automatic thresholding subspaces compare it exhaustive list thirteen estimators that could achieve...
Functional ultrasound imaging with high spatiotemporal resolution monitors brain function in babies.
The advent of neuroimaging has increased our understanding brain function. While most brain-wide functional imaging modalities exploit neurovascular coupling to map activity at millimeter resolutions, the recording responses microscopic scale in mammals remains privilege invasive electrophysiological or optical approaches, but is mostly restricted either cortical surface vicinity implanted sensors. Ultrasound localization microscopy (ULM) achieved transcranial cerebrovascular flow, up...
Abstract Remote and precisely controlled activation of the brain is a fundamental challenge in development brain–machine interfaces for neurological treatments. Low-frequency ultrasound stimulation can be used to modulate neuronal activity deep brain, especially after expressing ultrasound-sensitive proteins. But so far, no study has described an ultrasound-mediated strategy whose spatiotemporal resolution acoustic intensity are compatible with mandatory needs interfaces, particularly visual...
<b>Purpose:</b> Objective Shear wave elastography (SWE) enabled living tissue assessment of stiffness. This is routinely used for breast, thyroid and liver diseases, but there currently no data the brain. We aim to characterize elasticity normal brain parenchyma tumors using SWE. <b>Materials Methods:</b> Patients with scheduled tumor removal were included in this study. In addition standard ultrasonography, intraoperative SWE an ultrafast ultrasonic device was measure each its surrounding...
Ultrafast Doppler imaging was introduced as a technique to quantify blood flow in an entire 2-D field of view, expanding the application ultrasound highly sensitive anatomical and functional mapping vessels. We have recently developed 3-D ultrafast imaging, that can produce thousands volumes per second, based on plane diverging wave emissions, demonstrated its clinical feasibility human subjects vivo. In this study, we show noninvasive power Doppler, pulsed color be used perform vessels...
Abstract Rapid eye movement sleep (REMS) is a peculiar brain state combining the behavioral components of and electrophysiological profiles wake. After decades research our understanding REMS still precluded by difficulty to observe its spontaneous dynamics lack multimodal recording approaches build comprehensive datasets. We used functional ultrasound (fUS) imaging concurrently with extracellular recordings local field potentials (LFP) reveal brain-wide spatiotemporal hemodynamics single...
Functional ultrasound imaging (fUS) is an emerging technique that detects changes of cerebral blood volume triggered by brain activation. Here, we investigate the extent to which fUS faithfully reports local neuronal activation combining and two-photon microscopy (2PM) in a co-registered single voxel volume. Using machine-learning approach, compute validate transfer functions between dendritic calcium signals specific neurons vascular measured at both microscopic mesoscopic levels. We find...
Abstract Clinicians have long been interested in functional brain monitoring, as reversible losses often precedes observable irreversible structural insults. By characterizing neonatal cerebral networks, resting-state connectivity is envisioned to provide early markers of cognitive impairments. Here we present a pioneering bedside deep imaging at 250-μm resolution on human neonates using ultrasound. Signal correlations between regions unveil interhemispheric very preterm newborns....
In vivo mapping of the full vasculature dynamics based on Ultrafast Doppler is showed noninvasively in challenging case neonatal brain. Contrary to conventional pulsed-wave (PW) Ultrasound limited for >40 years estimation vascular indices at a single location, ultrafast frame rate (5,000 Hz) obtained using plane-wave transmissions leads simultaneous spectra all pixels wide field-of-view images within cardiac cycle and high sensitivity imaging. Consequently, 2D quantitative maps...
Abstract Prematurity and fetal growth restriction (FGR) are frequent conditions associated with adverse neurocognitive outcomes. We have previously identified early deregulation of genes controlling neuroinflammation as a putative mechanism linking FGR abnormal trajectory the developing brain. While oxytocin system was also found to be impaired following perinatal events, its role in modulation brain is still unknown. used double‐hit rat model injury induced by gestational low protein diet...
Fetal growth restriction (FGR) is a major complication of human pregnancy, frequently resulting from placental vascular diseases and prenatal malnutrition, associated with adverse neurocognitive outcomes throughout life. However, the mechanisms linking poor fetal impairment are unclear. Here, we aimed to correlate changes in gene expression induced by FGR rats abnormal cerebral white matter maturation, brain microstructure, cortical connectivity vivo. We investigated model low-protein-diet...
A major challenge in neuroscience is to longitudinally monitor whole brain activity across multiple spatial scales the same animal. Functional UltraSound (fUS) an emerging technology that offers images of cerebral blood volume over large portions. Here we show for first time its capability resolve functional organization sensory systems at awake animals, both within small structures by precisely mapping and differentiating responses, between elucidating connectivity scheme top-down...
Preterm birth is associated with cerebrovascular development disruption and can induce white matter injuries (WMI). Transfontanellar ultrasound Doppler the most widely used clinical imaging technique to monitor neonatal cerebral vascularisation haemodynamics based on vascular indexes such as resistivity index (RI); however, it has poor predictive value for brain damage. Indeed, these RI measurements are currently limited large vessels, leading a very probing of brain’s vascularisation, which...
Hemodynamic functional ultrasound imaging (fUS) of neural activity provides a unique combination spatial coverage, spatiotemporal resolution and compatibility with freely moving animals. However, deep transcranial monitoring brain the dynamics in slow-flowing blood vessels remains challenging. To enhance fUS capabilities, we introduce biomolecular hemodynamic enhancers based on gas vesicles (GVs), genetically encodable contrast agents derived from buoyant photosynthetic microorganisms. We...
Abstract During locomotion, theta and gamma rhythms are essential to ensure timely communication between brain structures. However, their metabolic cost contribution neuroimaging signals remain elusive. To finely characterize neurovascular interactions during we simultaneously recorded mesoscale hemodynamics using functional ultrasound (fUS) local field potentials (LFP) in numerous structures of freely-running overtrained rats. Locomotion events were reliably followed by a surge blood flow...