A5102800390- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Calibration and Measurement Techniques
- Advanced Memory and Neural Computing
- 3D Printing in Biomedical Research
- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- EEG and Brain-Computer Interfaces
- Anatomy and Medical Technology
- Surgical Simulation and Training
- Optical Systems and Laser Technology
- Advanced X-ray Imaging Techniques
- Particle Detector Development and Performance
- Adaptive optics and wavefront sensing
- Biosensors and Analytical Detection
- Electrowetting and Microfluidic Technologies
- Gene Regulatory Network Analysis
- Neurological disorders and treatments
- Tropical and Extratropical Cyclones Research
- X-ray Spectroscopy and Fluorescence Analysis
- Leaf Properties and Growth Measurement
- Remote Sensing in Agriculture
- Ultrasound and Hyperthermia Applications
- Additive Manufacturing and 3D Printing Technologies
- Electrical and Bioimpedance Tomography
Inserm
2020-2024
Institut de la Vision
2019-2024
Sorbonne Université
2020-2024
Centre National de la Recherche Scientifique
2020-2024
Can Tho University
2024
Université Gustave Eiffel
2023
Imagerie Adaptative Diagnostique et Interventionnelle
2020-2021
Université de Lorraine
2020-2021
University of California, Irvine
1987-2011
Irvine University
2011
Abstract Remote and precisely controlled activation of the brain is a fundamental challenge in development brain–machine interfaces for neurological treatments. Low-frequency ultrasound stimulation can be used to modulate neuronal activity deep brain, especially after expressing ultrasound-sensitive proteins. But so far, no study has described an ultrasound-mediated strategy whose spatiotemporal resolution acoustic intensity are compatible with mandatory needs interfaces, particularly visual...
A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment “wrinkles”. Using this substrate, the functional human embryonic stem cell derived cardiomyocytes demonstrated. Detailed facts importance specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note: The publisher responsible...
Embryoid body (EB) formation closely recapitulates early embryonic development with respect to lineage commitment. Because it is greatly affected by cell-cell and cell-substrate interactions, the ability control initial number of cells in aggregates provide an appropriate substrate are crucial parameters for uniform EB formation. Here we report ultra-rapid fabrication culture method utilizing a laser-jet printer generate arrayed honeycomb microwells tunable sizes induction EBs from single...
Polyolefins are finding increased popularity in microfluidic applications due to their attractive mechanical, processing, and optical properties. While intricate features typically realized these thermoplastics by hot embossing injection molding, such fabrication approaches expensive slow. Here, we apply our shrink-induced approach—first demonstrated with polystyrene 'Shrinky-Dink' sheets—to create micro- nanostructures cross-linked polyolefin thin films. These multi-layered films shrink 95%...
As advances in microfluidics continue to make contributions diagnostics and life sciences, broader awareness of this expanding field becomes necessary. By leveraging low-cost microfabrication techniques that require no capital equipment or infrastructure, simple, accessible, effective educational modules can be made available for a broad range needs from middle school demonstrations college laboratory classes. These demonstrate key microfluidic concepts such as diffusion separation well...
Graphene-enabled micro-transistor arrays can be used to improve our understanding of how infraslow brain signals relate changes in cerebral blood flow.
This article presents the development and testing of reduced graphene oxide (rGO) microelectrode arrays for interfacing with retinal neurons, showcasing their potential high-density visual prosthetics.
Evaluating biocompatibility is a core essential step to introducing new material as candidate for brain-machine interfaces. Foreign body reactions often result in glial scars that can impede the performance of interface. Having high conductivity and large electrochemical window, graphene electrical stimulation with retinal prosthesis. In this study, non-functional devices consisting chemical vapor deposition (CVD) embedded onto polyimide/SU-8 substrates were fabricated study. The implanted...
Implantable neuroprosthetic devices such as electrocorticography (ECoG) and intracortical microelectrodes have the potential to restore neurological functions in disabled individuals. They constitute direct interface with body require long term efficiency. We propose an ultra-thin diamond-based implant tackle challenges related implantation, demonstrate its functionality on rodents. Here we take advantage of thin-film diamond generate not only electrodes but also thin passivation foil,...
Abstract The study was conducted to assess the site situation and propose solutions develop cropping area of pineapples in U Minh Thuong (UMT), Kien Giang province. used Object-Based Image Analysis (OBIA) classification method create a map pineapple 2016. Data on rainfall, soil type, temperature, water reserves are inherited from Department Agriculture Rural Development Province analyzed by GIS method. Water irrigation estimated based formula Mladen Todorovic, 2016 comparing freshwater...
As NASA's next major space X-ray observatory, the Constellation-X mission (Bookbinder et al. 2008) requires mirror assemblies with unprecedented characteristics that cannot be provided by existing optical technologies. In past several years, project has supported a vigorous technology development program. This program includes fabrication of lightweight segments slumping commercially available thin glass sheets, support and mounting these for accurate metrology, attachment purpose tests,...
Many neural interfaces used for therapeutic applications are based on extracellular electrical stimulation to control cell polarization and thus functional activity. Amongst them, retinal implants have been designed restore visual perception in blind patients affected by photoreceptor degeneration diseases, such as age-related macular (AMD) or retinitis pigmentosa (RP). While designing a interface, several aspects must be taken into account, like the efficiency related current distribution...
The ability to interrogate and track single cells over time in a high-throughput format would provide critical information for fundamental biological understanding of processes various applications, including drug screening toxicology. We have developed an ultrarapid simple method create single-cell wells controllable diameter depth with commodity shrink-wrap film tape. Using programmable CO(2) laser, we cut hole arrays into the tape then serves as shadow mask selectively etch by O(2)...
We provide an overview of the Constellation-X SXT development program. describe performance requirements and goals, status technology The has a 1.6-meter diameter, 10-meter focal length, is to have angular resolution exceeding 15 arc seconds. It modular design, incorporting lightweight, multiply nested, segmented Wolter Type I x-ray mirrors. All aspects design lend themselves mass-production. reflecting surfaces are produced by epoxy replication off precision mandrels onto glass substrates...
Abstract Remote, precisely controlled activation of the brain is a fundamental challenge in development brain-machine interfaces providing feasible rehabilitation strategies for neurological disorders. Low-frequency ultrasound stimulation can be used to modulate neuronal activity deep 1–7 , but this approach lacks spatial resolution and cellular selectivity loads with high levels acoustic energy. The combination expression ultrasound-sensitive proteins (‘sonogenetic stimulation’) provide...
The International X-Ray Observatory (IXO) is a NASA, ESA, and JAXA joint mission. It requires mirror assembly with unprecedented characteristics that cannot be provided by existing optical technologies. In the past several years, project office at NASA Goddard Space Flight Center has supported vigorous technology development program. This program includes fabrication of lightweight segments slumping commercially available thin glass sheets, support mounting these for accurate metrology,...
Abstract Bismuth chalcogenides have a groundbreaking impact on materials science because of their potential applications in spintronics and optoelectronics, especially for properties as topological insulators. Investigation the biocompatibility electrode material at tissue/electrode interface is essential to assess use insulators bioelectronics. Here, we addressed Bi2Se3 by demonstrating that porcine primary mixed retinal cells can survive its surface with or without poly‐D‐lysine/laminin...
Implantable neuroprosthetic devices such as electrocorticography (ECoG) and intracortical microelectrodes have the potential to restore neurological functions in disabled individuals. They constitute direct interface with body require long term efficiency. We propose an ultra-thin diamond-based implant tackle challenges related implantation, demonstrate its functionality on rodents. Here we take advantage of thin-film diamond generate not only electrodes but also thin passivation foil,...
Dimethyl sulphoxide (DMSO), 3 g/kg body weight, administered daily by the intraperitoneal route, potentiated proteinuria and formation of tubular casts in aminonucleoside puromycin (PA) induced nephrosis Sprague-Dawley rats. The effect was evident at 4 as well 8-9 days following PA administration. In absence PA, DMSO did not induce or cast formation. mechanism which enhanced is known.
Abstract Electroretinography (ERG) is a clinical test employed to understand and diagnose many retinopathies. ERG usually performed by placing macroscopic ring gold wire electrode on the cornea while flashing light onto eye measure changes in transretinal potential. However, electrodes are severely limiting since they do not provide flexible interface contact sensitive corneal tissue, making this technique highly uncomfortable for patient. Another major drawback opacity of electrodes, which...