A5083542048- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Anesthesia and Sedative Agents
- Immune Response and Inflammation
- Dermatology and Skin Diseases
- Ultrasound and Hyperthermia Applications
- Olfactory and Sensory Function Studies
- Immune responses and vaccinations
- Intensive Care Unit Cognitive Disorders
- Neural dynamics and brain function
- Tryptophan and brain disorders
- Tuberculosis Research and Epidemiology
- Anesthesia and Neurotoxicity Research
- Veterinary Pharmacology and Anesthesia
- Photoacoustic and Ultrasonic Imaging
Inserm
2021-2024
CEA Paris-Saclay
2023-2024
Université Paris-Saclay
2023-2024
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2023-2024
Infectious Disease Models and Innovative Therapies
2023-2024
Sorbonne Université
2021-2023
Institut de la Vision
2021-2023
Centre National de la Recherche Scientifique
2021-2023
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses
2023
Abstract Remote and precisely controlled activation of the brain is a fundamental challenge in development brain–machine interfaces for neurological treatments. Low-frequency ultrasound stimulation can be used to modulate neuronal activity deep brain, especially after expressing ultrasound-sensitive proteins. But so far, no study has described an ultrasound-mediated strategy whose spatiotemporal resolution acoustic intensity are compatible with mandatory needs interfaces, particularly visual...
Over the last 15 years, optogenetics has changed fundamental research in neuroscience and is now reaching toward therapeutic applications. Vision restoration strategies using are at forefront of these new clinical opportunities. But applications to human patients suffering from retinal diseases leading blindness raise important concerns on long-term functional expression optogenes efficient signal transmission higher visual centers. Here, we demonstrate non-human primates continued...
Abstract After clean drinking water, vaccination is the most impactful global health intervention. However, development of new vaccines against difficult-to-target diseases hampered by lack diverse adjuvants for human use. Of particular interest, none currently available induce Th17 cells. Here, we develop and test an improved liposomal adjuvant, termed CAF®10b, that incorporates a TLR-9 agonist. In head-to-head study in non-human primates (NHPs), immunization with antigen adjuvanted CAF®10b...
Development of new vaccines tailored for difficult-to-target diseases is hampered by a lack diverse adjuvants human use, and none the currently available induce Th17 cells. Here, we develop liposomal adjuvant, CAF®10b, that incorporates Mincle Toll-like receptor 9 agonists. In parallel mouse non-human primate studies comparing to CAF® already in clinical trials, report species-specific effects adjuvant composition on quality magnitude responses. When combined with antigen, CAF®10b induces...
Abstract Remote, precisely controlled activation of the brain is a fundamental challenge in development brain-machine interfaces providing feasible rehabilitation strategies for neurological disorders. Low-frequency ultrasound stimulation can be used to modulate neuronal activity deep 1–7 , but this approach lacks spatial resolution and cellular selectivity loads with high levels acoustic energy. The combination expression ultrasound-sensitive proteins (‘sonogenetic stimulation’) provide...
Neuromuscular blocking agents (NMBAs) are a crucial component of anesthesia and intensive care through the relaxation skeletal muscles. They can lead to adverse reactions such as postoperative residual neuromuscular block. Only one agent is capable an instant block reversal in deep situations, but restricted aminosteroid agents. Among animal models, non-human primates essential model for great diversity human disease models. The main objective this study was establish NMBA monitoring with...
ABSTRACT Background Neuromuscular blocking agents (NMBAs) are a crucial component of anaesthesia and intensive care. NMBAs family molecules defined by their ability to compete with acetylcholine for binding the receptor at neuromuscular junction. This functional homology relies on presence ammonium groups in all that, however, display vastly different chemical structures. Among animal models, non-human primates (NHP) an essential model great diversity human disease models but remain poorly...
Abstract Over the last 15 years, optogenetics has changed fundamental research in neuroscience, and is now reaching toward therapeutic applications. Vision restoration strategies using are at forefront of these new clinical opportunities. But applications to human patients suffering from retinal diseases leading blindness rise important concerns on long-term functional expression optogenes efficient signal transmission higher visual centers. Here we demonstrate non-human primates, continued...