A5011474619- Laser Applications in Dentistry and Medicine
- Microfluidic and Bio-sensing Technologies
- Ultrasound in Clinical Applications
- Photodynamic Therapy Research Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Venous Thromboembolism Diagnosis and Management
- Protein purification and stability
- 3D Printing in Biomedical Research
- Photoreceptor and optogenetics research
- Micro and Nano Robotics
- Central Venous Catheters and Hemodialysis
- Dermatologic Treatments and Research
- Advanced Malware Detection Techniques
- Genomics and Chromatin Dynamics
- Modular Robots and Swarm Intelligence
- Bee Products Chemical Analysis
- Cancer-related Molecular Pathways
- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- NF-κB Signaling Pathways
- Protein Kinase Regulation and GTPase Signaling
- Colorectal Cancer Treatments and Studies
- Cytokine Signaling Pathways and Interactions
- Optical Imaging and Spectroscopy Techniques
- Vascular Procedures and Complications
Loxo Oncology at Lilly (United States)
2024-2025
The Ohio State University
2012-2024
Texas A&M University
2024
Center for Biologics Evaluation and Research
2010-2024
United States Food and Drug Administration
2010-2024
Children's Hospital of Philadelphia
2011-2023
University of Pennsylvania
2012-2023
Chinese University of Hong Kong
2023
Victoria University of Wellington
2017-2022
Sumitomo Dainippon Pharma (United States)
2022
The use of low levels visible or near infrared light for reducing pain, inflammation and edema, promoting healing wounds, deeper tissues nerves, preventing cell death tissue damage has been known over forty years since the invention lasers. Despite many reports positive findings from experiments conducted in vitro, animal models randomized controlled clinical trials, LLLT remains controversial mainstream medicine. biochemical mechanisms underlying effects are incompletely understood,...
Background Despite over forty years of investigation on low-level light therapy (LLLT), the fundamental mechanisms underlying photobiomodulation at a cellular level remain unclear. Methodology/Principal Findings In this study, we isolated murine embryonic fibroblasts (MEF) from transgenic NF-kB luciferase reporter mice and studied their response to 810 nm laser radiation. Significant activation was observed fluences higher than 0.003 J/cm2 confirmed by Western blot analysis. activated...
Low-power laser–activated endogenous latent transforming growth factor–β1 (LTGF-β1) directs resident dental stem cell differentiation to promote dentin regeneration.
A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment “wrinkles”. Using this substrate, the functional human embryonic stem cell derived cardiomyocytes demonstrated. Detailed facts importance specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note: The publisher responsible...
Chinese translation Background: Adults who use wheelchairs have difficulty accessing physicians and receive less preventive care than their able-bodied counterparts. Objective: To learn about the accessibility of medical surgical subspecialist practices for patients with mobility impairment. Design: A telephone survey was used to try make an appointment a fictional patient obese hemiparetic, wheelchair, could not self-transfer from chair examination table. Setting: 256 endocrinology,...
8510 Background: While immunotherapy (IO) is established as the cornerstone of first-line treatment for KRAS-mutant NSCLC, outcomes remain suboptimal. Further progress may be achieved with addition targeted therapy to IO, an paradigm in some other cancer types (RCC), but historically challenging NSCLC. Here, we study pembrolizumab plus olomorasib, a potent and highly selective second-generation inhibitor GDP-bound KRAS G12C, NSCLC patients treated on LOXO-RAS-20001, phase 1/2 olomorasib...
94 Background: LY3537982 is an oral, potent, and highly selective inhibitor of GDP-bound KRAS G12C with unique pharmacologic properties that achieve high target occupancy at low absolute exposures. Here we present results GI tumors treated on LOXO-RAS-20001, a phase 1 study in patients (pts) mutation. Methods: Dose escalation followed mTPI-2 method. expansion included combination cetuximab colorectal cancer (CRC). All pts were naïve. Key objectives to determine the RP2D, safety, PK,...
3007 Background: Olomorasib is a potent and highly selective second-generation inhibitor of GDP-bound KRAS G12C, which preclinically delivers >90% sustained target occupancy. Here, we report updated results from LOXO-RAS-20001, phase 1/2 study olomorasib in patients with G12C-mutant advanced solid tumors (NCT04956640). Methods: Patients (pts) positive for G12C (tissue or plasma) were eligible. Dose escalation used mTPI-2 method, followed by expansion cohorts NSCLC (with/without prior...
Increasing the throughput and efficiency of cell culture process development has become increasingly important to rapidly screen optimize media parameters. This study describes application a miniaturized bioreactor system as scaled-down model for using CHO line expressing recombinant protein. The microbioreactor (M24) provides non-invasive online monitoring control capability parameters such pH, dissolved oxygen (DO), temperature at individual well level. A systematic evaluation M24...
Controlled transport of multiple individual nanostructures is crucial for nanoassembly and nanodelivery but challenging because small particle size. Although atomic force microscopy optical magnetic tweezers can control single particles, it extremely difficult to scale these technologies structures. Here, we demonstrate a "nano-conveyer-belt" technology that permits simultaneous tracking nanospecies in selected direction. The consists two components: nanocontainers, which encapsulate the...
Human rhinoviruses (HRV) are the leading cause of upper respiratory infections and have been postulated to trigger asthma exacerbations. However, whether HRV detected during crises because often accompany attacks, or they specifically elicit exacerbations, is unclear. Moreover, although several hypotheses advanced explain virus-induced their mechanism remains
Recent genome‐wide association studies suggest distinct roles for 12 human interferon‐alpha (IFN‐α) and 3 IFN‐λ subtypes that may be elucidated by defining the expression patterns of these sets genes. To overcome impediment high homology among each sets, we designed a quantitative real‐time PCR assay incorporates use molecular beacon locked nucleic acid (LNA) probes, in some instances, LNA oligonucleotide inhibitors. We then measured IFN subtype peripheral blood mononuclear cells purified...
Single cell study is gaining importance because of the cell-to-cell variation that exists within population, even after significant initial sorting. Analysis such at gene expression level could impact single functional genomics, cancer, stem-cell research, and drug screening. The on-chip monitoring individual cells in an isolated environment would prevent cross-contamination, provide high recovery yield, enable biological traits a level. These advantages experiments improvement for myriad...
Abstract Bacterial response to surface topography during biofilm formation was studied using 5 μm tall line patterns of poly (dimethylsiloxane) (PDMS). Escherichia coli cells attached on top protruding were found align more perpendicularly the orientation when pattern narrowed. Consistently, cell cluster per unit area wide reduced by 14-fold compared flat PDMS. Contrasting colony formation, narrow longer and had higher transcriptional activities, suggesting that such unfavorable may present...
In the A/J strain of mice, urethane (ethyl carbamate) induces lung hyperplasia, adenoma, and adenocarcinoma in a time-dependent manner. These distinct morphological stages may correlate with sequential molecular genetic changes this mouse model. To test hypothesis, we investigated presence mutations involving Ki-ras p53 urethane-induced lesions mice at early late tumorigenesis. We precisely microdissected 40 from paraffin-embedded sections. around codon 61 exons 5–8 were identified by...
Analysis of cell-to-cell variation can further the understanding intracellular processes and role individual cell function within a larger population. The ability to precisely lyse single cells be used release cellular components resolve heterogeneity that might obscured when whole populations are examined. We report method position on silicon nanowire nanoribbon biological field effect transistors. In this study, HT-29 cancer were positioned top transistors by manipulating magnetic beads...
Objective: The purpose of this study was to Investigate the effect 810-nm low level laser therapy (LLLT) on dendritic cells (DC) in vitro. Background data: LLLT can enhance wound healing and increase cell proliferation survival, is used treat inflammatory conditions. However there are reports that stimulate leukocytes could therefore be pro-inflammatory. Recently, DC have been found play an important role inflammation immune response. Methods: Murine bone-marrow-derived were isolated,...
Entropy-based features have been widely utilized for detecting DDoS attacks in recent years. However, existing approaches mainly focus on using a small number of entropy-based to distinguish attack traffic from normal traffic. The drawback this approach is that it limits the type can be detected. To overcome problem, we proposed set new help detect accurately and introduced novel multi classifier system based multiple machine learning classifiers increase generality accuracy low-intensity...
Much research effort has been conducted to introduce intelligence into communication networks in order enhance network performance. Communication networks, both wired and wireless, are ever-expanding as more devices increasingly connected the Internet. This survey introduces machine learning motivations behind it for creating cognitive networks. We then discuss statistical techniques predict future traffic classify each short-term or long-term applications. Furthermore, sub-categorized their...