A5100358646- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Catalytic Cross-Coupling Reactions
- Chemical Synthesis and Reactions
- Water Quality Monitoring and Analysis
- Cyclopropane Reaction Mechanisms
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Oxidative Organic Chemistry Reactions
- Fluorine in Organic Chemistry
- Water Treatment and Disinfection
- Synthesis of β-Lactam Compounds
- Catalytic Processes in Materials Science
- Catalysts for Methane Reforming
- Nanomaterials for catalytic reactions
- Zeolite Catalysis and Synthesis
- Melanoma and MAPK Pathways
- Synthesis and Biological Evaluation
- Membrane Separation Technologies
- Organic Chemistry Cycloaddition Reactions
- Click Chemistry and Applications
- Spectroscopy and Chemometric Analyses
- Marine and coastal ecosystems
- Wastewater Treatment and Nitrogen Removal
Taiyuan University of Technology
2016-2025
China Institute of Water Resources and Hydropower Research
2024-2025
Beijing University of Civil Engineering and Architecture
2019-2024
Beijing University of Technology
2014-2024
University of Saskatchewan
2024
South China University of Technology
2024
Taizhou University
2024
Wuhan Institute of Technology
2023
Baotou Medical College
2022-2023
First People's Hospital of Yunnan Province
2022
Iron was used as the catalyst for direct C-H functionalization/C-S bond formation under mild conditions. Various substrates could afford benzothiazoles in moderate to excellent yields. Preliminary mechanistic studies revealed that pyridine played a crucial role high yields and selectivities.
The integration of energy harvesting and storage in this device not only enables the conversion ambient into electricity, but also provides a sustainable power source for various electronic devices systems.
Abstract Anisole and fluoroanisoles display distinct conformational preferences, as evident from a survey of their crystal structures. In addition to altering the free ligand conformation, various degrees fluorination have strong impact on physicochemical pharmacokinetic properties. Analysis anisole fluoroanisole matched molecular pairs in Pfizer corporate database reveals interesting trends: 1) PhOCF 3 increases log D by ∼1 unit over PhOCH compounds; 2) shows lower passive permeability...
A simple and efficient metal-free sulfenylation/cyclization of aryl alkynoates has been developed, obtaining various 3-sulfenylated coumarins in moderate to excellent yields. In the presence BF3·Et2O, stable readily accessible N-sulfanylsuccinimides were employed as electrophiles induce 6-endo-dig electrophilic cyclization alkynoates. The reaction using substrates bearing a methoxy group on phenoxy ring proceeded an exclusively distinct pathway via either ipso sulfenylcyclization or...
A general method for the synthesis of oxazolines and oxazoles was developed through I2-catalyzed C–O bond formation dehydrogenation with same oxidant, TBHP. By simply tuning reaction bases, either or were selectively produced from β-acylamino ketones.
Food-microbiota-host interactions provide an overarching framework for understanding the function of gut microbiota axis. Diet is a major modulator microbiota. Plant-based foods are rich in phytochemicals; therefore, it essential to assess such and elucidate mechanisms underlying their action. In this review, we summarize role communication between brain, liver, lung, kidney, joints, as well axis diseases involving these organs. addition, effects phytochemicals from plant-based on via...
A solvent-controlled unprecedented tandem reaction of readily accessible SeO
Abstract. Amidst drastic environmental changes, the intricate interplay and feedback mechanisms in water-vegetation-atmosphere nexus experience alteration. Previous research primarily centers on responses among variables within this system, with little known about whether how these (sensitivities) change. Here, we employ Evapotranspiration Stress Index (ESI) to represent equilibrium of develop a memory dynamic linear model based Bayesian forward filtering. The takes into account carry-over...
The first catalytic asymmetric three-component allylation of aldimines has been developed. In the presence L-ramipril acid-oriented N,N′-dioxide–ScIII complex catalyst, a range homoallylic amines were formed in excellent enantioselectivities (up to 97 % ee) with good yields from corresponding aldehydes, 2-aminophenol and allyltributyltin (see scheme).
Structure-based virtual screening was applied to design combinatorial libraries discover novel and potent soluble epoxide hydrolase (sEH) inhibitors. X-ray crystal structures revealed unique interactions for a benzoxazole template in addition the conserved hydrogen bonds with catalytic machinery of sEH. By exploitation favorable binding elements, two iterations library based on amide coupling were employed, guided principally by docking results enumerated products. Biological demonstrated as...
The <italic>in situ</italic> forming hydrogels based on oppositely charged poly(<sc>l</sc>-glutamic acid) (PLGA) and chitosan (CS) were prepared <italic>via</italic> a Schiff base crosslinking reaction.
Abstract An efficient synthetic strategy for the unique class of pyrazolo[1,2‐ a ]cinnolines was developed through rhodium‐catalyzed oxidative coupling N ‐aryl‐1 H ‐pyrazol‐5(4 )‐ones with internal alkynes. This protocol features use pyrazolone function in substrate as an intrinsic directing group, hexafluoroisopropyl alcohol (HFIP) solvent, and mild reaction conditions well wide scope. magnified image
An efficient method for the synthesis of 4-sulfenyl isoxazoles has been developed via AlCl3-mediated electrophilic cyclization/sulfenylation 2-alkyn-1-one O-methyloximes. Remarkably, N-arylsulfanylsuccinimides are employed as electrophiles construction 4-arylsulfanyl isoxazoles, and 4-alkylsulfanyl accessed with dialkyl disulfides electrophiles.
A general and practical strategy for the construction of various keto-substituted isoxazolidines <italic>via</italic> one-pot three-component reaction easily accessible, safer more stable sulfoxonium ylides, nitrosoarenes olefins is described.
PH-797804 is a diarylpyridinone inhibitor of p38alpha mitogen-activated protein (MAP) kinase derived from racemic mixture as the more potent atropisomer (aS), first proposed by molecular modeling and subsequently confirmed experiments. On basis structural comparison with different biaryl pyrazole template supported dozens high-resolution crystal structures complexes, predicted to possess high level specificity across broad human genome. We used bioinformatics approach identify two...
Suzuki-Miyaura cross-couplings of arenediazonium salts with arylboronic acids catalyzed by highly active aluminium hydroxide-supported palladium nanoparticles catalyst have been investigated for the first time. The reactions are performed at 25 °C in MeOH without any base and ligand to afford biaryls good excellent yields under non-anhydrous non-degassed conditions.
A palladium-catalyzed dual C-H activation to construct C-C/C-N bonds for one-pot synthesis of benzo[c]pyrazolo[1,2-a]cinnolin-1-ones is successfully developed. This approach involves using a pyrazolone moiety as an internal directing group activation, and provides flexible strategy access this polycyclic skeleton.