Jian He

ORCID: 0000-0001-8117-5555
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Research Areas
  • Advanced Nanomaterials in Catalysis
  • Advanced biosensing and bioanalysis techniques
  • Electrochemical sensors and biosensors
  • ZnO doping and properties
  • Advanced Photocatalysis Techniques
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Intracranial Aneurysms: Treatment and Complications
  • Nanocluster Synthesis and Applications
  • Apelin-related biomedical research
  • ATP Synthase and ATPases Research
  • 2D Materials and Applications
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Phagocytosis and Immune Regulation
  • Sulfur Compounds in Biology
  • MicroRNA in disease regulation
  • Gas Sensing Nanomaterials and Sensors
  • Biosensors and Analytical Detection
  • Neurological Disease Mechanisms and Treatments
  • Microtubule and mitosis dynamics
  • Neurosurgical Procedures and Complications

Gansu Provincial Maternal and Child Health Hospital
2025

University of South China
2008-2024

Nanozymes are widely used in detecting biomarkers. However, designing nanozymes exhibiting high peroxidase-like activity is challenging. This study aimed to synthesize two types of nanozymes, Pd–Rh–Ir nanozyme (PRI nanozyme) and Pd–Ir (PI nanozyme), similar morphologies enhanced activities. The first comprised palladium, rhodium, iridium while the second palladium nanozyme). PRI exhibited a higher than PI nanozyme. Rhodium subsurface can lower hydrogen peroxide decomposition energy increase...

10.1021/acsanm.2c05400 article EN ACS Applied Nano Materials 2023-03-06

Developing ultrasensitive lateral flow immunoassays (LFIAs) has garnered significant attention in the field of point-of-care testing. In this study, a trimetallic dendritic nanozyme (Pd@Pt–Ru) was synthesized through Ru deposition on Pd@Pt core and utilized to enhancing sensitivity LFIAs. Pd@Pt–Ru exhibited Km value 5.23 mM for detecting H2O2, which indicates an H2O2 affinity comparable with that horseradish peroxidase. The surface layer reduces activation energy barrier, increases maximum...

10.1021/acs.nanolett.4c01568 article EN Nano Letters 2024-06-27

To inhibit the growth of bacteria, DA-PPI nanozyme with enhanced peroxidase-like activity was synthesized. The obtained by depositing high-affinity element iridium (Ir) on surface Pd-Pt dendritic structures. morphology and composition were characterized using SEM, TEM, XPS. kinetic results showed that possessed a higher than PL, ESR, DFT employed to explain high peroxidase activity. As proof concept, could effectively E. coli (G-) S. aureus (G+) due its study provides new idea for design...

10.1155/2023/1689455 article EN cc-by Bioinorganic Chemistry and Applications 2023-02-15

The trimetallic dendritic Pd–Pt–Ru (PPR) nanozyme with enhanced peroxidase-like activity was synthesized and applied for the assay of TAC in drinks several herbs.

10.1039/d2ay01560a article EN Analytical Methods 2022-12-09

To explore the effect of miR-1 on neuronal apoptosis in rats with stroke through ERK signaling pathway.

10.1155/2021/9988534 article EN cc-by BioMed Research International 2021-08-19

The article has been withdrawn at the request of authors journal Current Molecular Medicine.Bentham Science apologizes to readers for any inconvenience this may have caused.The Bentham Editorial Policy on Article Withdrawal can be found https://benthamscience.com/editorial-policies-main.php.It is a condition publication that manuscripts submitted not published and will simultaneously or elsewhere. Furthermore, data, illustration, structure table elsewhere must reported, copyright permission...

10.2174/1566524022666220804152049 article EN Current Molecular Medicine 2022-08-04

10.3724/sp.j.1008.2015.00069 article EN Academic Journal of Second Military Medical University 2015-01-01
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