A5008835806- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Photodynamic Therapy Research Studies
- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Electrochemical sensors and biosensors
- Nanoparticle-Based Drug Delivery
- Molecular Sensors and Ion Detection
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Advanced Photocatalysis Techniques
- Inhalation and Respiratory Drug Delivery
- Analytical Chemistry and Sensors
- Dendrimers and Hyperbranched Polymers
- Cancer Immunotherapy and Biomarkers
- Antimicrobial Peptides and Activities
- Extracellular vesicles in disease
- Cancer Research and Treatments
- Supramolecular Self-Assembly in Materials
- Hepatocellular Carcinoma Treatment and Prognosis
- Sulfur Compounds in Biology
- Bacterial biofilms and quorum sensing
University of South China
2020-2025
Hunan Institute of Technology
2024
Hunan Provincial Maternal and Child Health Hospital
2024
Abstract Tumor microenvironment (TME)‐triggered phototheranostic platform offers a feasible strategy to improve cancer diagnosis accuracy and minimize treatment side effects. Developing stable biocompatible molecular for TME‐activated second near‐infrared (NIR‐II) fluorescence imaging‐guided multimodal cascade therapy is promising creating desirable anticancer agents. Herein, new NIR‐II activatable (IR‐FEP‐RGD‐S‐S‐S‐Fc) presented actively targeted tumor imaging hydrogen sulfide (H 2 S)...
Abstract Effectively interfering energy metabolism in tumor cells and simultaneously activating the vivo immune system to perform attacks are meaningful for treatment. However, precisely targeted therapy is still a huge challenge. Herein, mitochondrial‐targeting phototheranostic system, FE‐T nanoparticles (FE‐T NPs) developed damage mitochondria change immunosuppressive microenvironment. NPs engineered by encapsulating near‐infrared (NIR) absorbed photosensitizer IR‐FE‐TPP within amphiphilic...
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of characterized by an extremely poor prognosis. Photoimmunotherapy has emerged as promising strategy for the treatment TNBC. This approach works selectively destroying tumor cells, releasing tumor-associated antigens, activating immune system, and effectively inhibiting proliferation metastasis. However, majority current phototheranostic approaches are hindered limited tissue penetration in first near-infrared (NIR-I)...
Phototherapy is a conducive and non-invasive strategy for cancer therapy under light irradiation. Inspiringly, fluorescence imaging in the second near-infrared window (NIR-II, 1000-1700 nm) holds great promise imaging-guided phototherapy with deep penetration high spatiotemporal resolution. However, most phototherapeutics still face challenges, including complicated synthesis of agents, potential biotoxicity unsatisfied therapeutic outcomes. Herein, laser triggered molecular photosensitizer...
Pathogenic bacteria infections bring about a substantial risk to human health. Given the development of antibiotic-resistance bacteria, alternative antibacterial strategies with great inactivation efficiency and bacteria-binding ability are extremely attractive. In this work, metabolic labeling photosensitizer, prepared by coupling commercial IR820 d-propargylglycine (a type d-amino acid, DAA) via straightforward one-step incubation (IR820-DAA), could metabolically be incorporated into...
The activable NIR-based phototheranostic nanoplatform (NP) is considered an efficient and reliable tumor treatment due to its strong targeting ability, flexible controllability, minimal side effects, ideal therapeutic effect. This work describes the rational design of a second near-infrared (NIR-II) fluorescence imaging-guided organic NP (FTEP-TBFc NP). molecular-engineered has sensitive response glutathione (GSH), generating hydrogen sulfide (H2S) gas, delivering ferrocene molecules in...
Abstract Malignant tumors seriously threaten human life and well‐being. Emerging Near‐infrared II (NIR‐II, 1000–1700 nm) phototheranostic nanotechnology integrates diagnostic treatment modalities, offering merits including improved tissue penetration enhanced spatiotemporal resolution. This remarkable progress has opened promising avenues for advancing tumor theranostic research. The microenvironment (TME) differs from normal tissues, exhibiting distinct attributes such as hypoxia, acidosis,...
Currently, clinical therapeutic strategies for nasopharyngeal carcinoma (NPC) confront insurmountable dilemmas in which surgical resection is incomplete and chemotherapy/radiotherapy has significant side effects. Phototherapy offers a maneuverable, effective, noninvasive pattern NPC therapy. Herein, we developed lysosome-targeted pH-responsive nanophototheranostic near-infrared II (NIR-II) fluorescence imaging-guided photodynamic therapy (PDT) photothermal (PTT) of NPC. A S-D-A-D-S-type...
Hepatocellular carcinoma (HCC) is typically diagnosed at intermediate to advanced stage, making surgical treatment unfeasible. Conversion therapy aims reduce tumor improve hepatic resection feasibility, and lower recurrence rates. Since traditional therapies are often accompanied by uncertainty of efficacy, there an urgent need explore new strategies. Near-infrared phototheranostics technology provides a way for HCC diagnosis its excellent optical properties. However, complex preparation...
The advancement of mitochondria-targeted near-infrared-II (NIR-II) excitable phototheranostics constitutes a promising strategy for improving fluorescence-image-guided cancer phototherapy. However, developing phototheranostic agents that simultaneously combine high-contrast NIR-II fluorescence imaging with effective multimodal therapeutic techniques remains substantial challenge. Herein, we reported shielding-donor-acceptor-donor-shielding structured (FCD-T) by molecular engineering...
Establishing a phototheranostic platform constructed by the second near-infrared (NIR-II) region has proved revolutionary and promising strategy for cancer treatment. However, antitumor effectiveness is severely limited monotonicity of NIR-photothermal therapy (HPTT) modality tumor thermotolerance caused production heat shock proteins (HSPs). Here, minimalistic approach used to construct an organic nanoplatform (IFT@PEG-GOX NPs) with reciprocal cyclic promotion hypothermia starvation...
Abstract Orthotopic advanced hepatic tumor resection without precise location and preoperative downstaging may cause clinical postoperative recurrence metastasis. Early accurate monitoring size reduction based on the multifunctional diagnostic-therapeutic integration platform could improve real-time imaging-guided efficacy. Here, a Near-Infrared II/Photoacoustic Imaging/Magnetic Resonance Imaging (NIR-II/PAI/MRI) organic nanoplatform IRFEP-FA-DOTA-Gd (IFDG) is developed for integrated...
The efficacy of immunotherapy in treating triple-negative breast cancer (TNBC) has been restricted due to its low immunogenicity and suppressive immune microenvironment. Bacterial outer membrane vesicles (OMVs) have emerged as innovative immunotherapeutic agents antitumor therapy by stimulating the innate system, but intricate modifications undesirable multiple dose administration severely hinder their utility. Herein, a two-step bacterial metabolic labeling technique was utilized for...
Human health, environmental contamination, and food safety are tightly associated with hydrogen sulfide (H2S). The safe highly sensitive monitoring of H2S in tissues, organs, blood has presented ongoing challenges. Herein, a novel near-infrared (NIR)-activated water-soluble molecular probe, denoted as IR820-TPY-Cu was developed for detecting sulfide. This probe is built upon the fluorescent molecule IR820, derivative Indocyanine green (ICG). Upon reacting H2S, exhibits active fluorescence...
<title>Abstract</title> Hepatocellular carcinoma (HCC) is typically diagnosed at an intermediate to advanced stage, making surgical treatment unfeasible. Conversion therapy aims reduce tumor improve hepatic resection feasibility, and lower recurrence rates. Since traditional therapies are often accompanied by uncertainty of efficacy, there urgent need explore new strategies. Near-infrared phototheranostics technology provides a way for HCC diagnosis its excellent optical properties. However,...