A5100611883- Autophagy in Disease and Therapy
- Cytomegalovirus and herpesvirus research
- Wound Healing and Treatments
- interferon and immune responses
- Transplantation: Methods and Outcomes
- Ferroptosis and cancer prognosis
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Photodynamic Therapy Research Studies
- Liver Disease Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Circular RNAs in diseases
- Toxoplasma gondii Research Studies
- Pancreatic and Hepatic Oncology Research
- Renal Transplantation Outcomes and Treatments
- Advanced Photocatalysis Techniques
- Diagnosis and treatment of tuberculosis
- Chemokine receptors and signaling
- Mycobacterium research and diagnosis
- Estrogen and related hormone effects
- Lipid metabolism and disorders
- Diabetic Foot Ulcer Assessment and Management
- Organ and Tissue Transplantation Research
- Inflammatory mediators and NSAID effects
- Sepsis Diagnosis and Treatment
University of South China
2015-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2024
Wenzhou Medical University
2024
Hefei Institutes of Physical Science
2017-2024
Chinese Academy of Sciences
2017-2024
Ningxia Medical University
2022
The First People's Hospital of Shunde
2019-2021
Southern Medical University
2008-2021
Wuxi People's Hospital
2021
Nanjing Medical University
2021
Abstract Background Though (1S, 3R)-RSL3 has been used widely in basic research as a small molecular inducer of ferroptosis, the toxicity on normal cells and poor pharmacokinetic properties RSL3 limited its clinical application. Here, we investigated synergism non-thermal plasma (NTP) low-concentration attempted to rise sensitivity NSCLC RSL3. Methods CCK-8 assay was employed detect change cell viability. Microscopy flowcytometry were applied identify lipid peroxidation, death reactive...
Hepatocellular carcinoma (HCC) is typically diagnosed at intermediate to advanced stage, making surgical treatment unfeasible. Conversion therapy aims reduce tumor improve hepatic resection feasibility, and lower recurrence rates. Since traditional therapies are often accompanied by uncertainty of efficacy, there an urgent need explore new strategies. Near-infrared phototheranostics technology provides a way for HCC diagnosis its excellent optical properties. However, complex preparation...
Background and aims The aim of the present study was to evaluate serum Dickkopf-1 (Dkk-1) as a marker for early detection hepatocellular carcinoma (HCC), well prognostic prediction HCC after hepatic resection. Methods One-hundred four cases matched fresh tissue specimens adjacent non-tumorous liver (ANLT) were obtained RT-PCR, qRT-PCR, western blot immunohistochemistry assays. Sera collected from patients with (n=184), benign tumors (n=29), cirrhosis (n=174), non-cirrhotic hepatitis B...
Abstract Background Chemokine (C-C motif) ligand 18 (CCL18) affects the malignant progression of varying cancers by activating chemokine receptors. Our previous work has shown that CCL18 promotes hyperplasia and invasiveness oral cancer cells; however, cognate receptors involved in pathogenesis squamous cell carcinoma (OSCC) have not yet been identified. This study aimed to investigate molecular mechanisms which underlie promotive effects on OSCC binding functional Methods The expression...
Sepsis after trauma increases the risk of mortality rate for patients in intensive care unit (ICUs). Currently, it is difficult to predict outcomes individual with sepsis due complexity causative pathogens and lack specific treatment. This study aimed identify metabolomic biomarkers multiple those accompanied sepsis. Therefore, metabolic profiles healthy persons designated as normal controls (NC), (MT), complicated (MTS) (30 cases each group) were analyzed ultra-high performance liquid...
Cartilage defects in temporomandibular disorders (TMD) lead to chronic pain and seldom heal. Synovium-derived mesenchymal stem cells (SMSCs) exhibit superior chondrogenesis have become promising seed for cartilage tissue engineering. However, local inflammatory conditions that affect the repair of articular by SMSCs present a challenge, specific mechanism through which function remains unclear. Thus, it is important explore under TMD such they can be used more effectively clinical treatment....
Oral tongue squamous cell carcinoma (OTSCC) is one of the most aggressive pathological types head and neck carcinoma, presents with rapid local invasion metastasis. The present study confirmed that long non‑coding (lnc) RNA MIR4713HG was markedly upregulated in both OTSCC tissues lines associated poor survival. performed a series experiments to investigate impact on revealed upregulation had crucial role promoting proliferation metastasis <em>in vitro</em> vivo</em>. By applying...
// Lu Li 1, 4 , Wang Kevin M. Prise 2 K.N. Yu 3 Guodong Chen 1 Lianyun 6 Yide Mei 7 Wei Han 5 Anhui Province Key Laboratory of Medical Physics and Technology/Center Technology, Hefei Institutes Physical Sciences, Chinese Academy Hefei, Anhui, China Centre for Cancer Research & Cell Biology, Queen’s University, Belfast, UK Department Materials Science, City University Hong Kong, Tat Chee Avenue, Kowloon Tong, Kong Clinical College Integrated Traditional Western Medicine,...
Although non-thermal plasma (NTP) has been proved to be an effective way kill cancer cells, the mechanism of NTP-induced cell death is still not clear. In this study, we found that NTP exposure caused reactive oxygen species generation and apoptosis in A549 MDA-MB-231 cells. Meanwhile, treatment also induced autophagy, as evidenced by formation acidic vesicular organelles conversion LC3-I LC3-II. Suppression autophagy chloroquine significantly increased death, indicating acted a protective...
To investigate the use of glucocorticoids in patients with severe community-acquired pneumonia (SCAP) intensive care unit (ICU) Hospitals Zhejiang Province and to provide a reference for guiding clinical SCAP patients.To draw up questionnaire Chinese international guidelines, knowledge (CAP) related guidelines by doctors hospitals above secondary level Email. Then valid was analyzed.In June 2016, 340 questionnaires were distributed, all returned after 2 months, 333 valid; from 45 ICUs...
Background and Purpose Skin flaps are among the most important means of wound repair in clinical settings. However, partial or even total distal necrosis may occur after a flap operation, with severe consequences for both patients doctors. This study investigated whether tert ‐butylhydroquinone (TBHQ), known agonist transcription factor nuclear erythroid 2‐related 2 (Nrf2), an antioxidant, could promote skin survival. Experimental Approach McFarlane models were established male...
<title>Abstract</title> Hepatocellular carcinoma (HCC) is typically diagnosed at an intermediate to advanced stage, making surgical treatment unfeasible. Conversion therapy aims reduce tumor improve hepatic resection feasibility, and lower recurrence rates. Since traditional therapies are often accompanied by uncertainty of efficacy, there urgent need explore new strategies. Near-infrared phototheranostics technology provides a way for HCC diagnosis its excellent optical properties. However,...
Abstract Skin flap transplantation is a primary method for wound repair; however, postoperative skin necrosis remains significant challenge. Kaempferol, flavonol abundant in various foods, exhibits diverse pharmacological effects. This study investigated the potential targets of kaempferol treating ischemia–reperfusion (I/R) injury through network pharmacology and molecular docking, followed by vivo validation. Using SwissTargetPredict, PubChem, SymMap V2, GeneCards databases, 174 target...