A5004758809- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- Neurology and Historical Studies
- Botulinum Toxin and Related Neurological Disorders
- Palliative Care and End-of-Life Issues
- Autism Spectrum Disorder Research
- Health Sciences Research and Education
- Geriatric Care and Nursing Homes
- Intracerebral and Subarachnoid Hemorrhage Research
- Olfactory and Sensory Function Studies
- Nuclear Receptors and Signaling
- Acute Ischemic Stroke Management
- Dementia and Cognitive Impairment Research
- Neurosurgical Procedures and Complications
- Genetic Neurodegenerative Diseases
- Spatial Neglect and Hemispheric Dysfunction
- Cerebrovascular and Carotid Artery Diseases
- Glycogen Storage Diseases and Myoclonus
- Healthcare Decision-Making and Restraints
- Chronic Disease Management Strategies
- Academic Writing and Publishing
- Elder Abuse and Neglect
- Polyomavirus and related diseases
University of Pennsylvania
2021-2025
California University of Pennsylvania
2021-2025
American Academy of Neurology
2023
Wake Forest University
2023
Children's Hospital of Philadelphia
2023
Emory University
2023
Hospital of the University of Pennsylvania
2017-2023
Health Economics and Outcomes Research (United Kingdom)
2023
Philadelphia VA Medical Center
2021-2022
Baylor College of Medicine
2022
In the research reported here, we tested hypothesis that sustained engagement in learning new skills activated working memory, episodic and reasoning over a period of 3 months would enhance cognitive function older adults. three conditions with high demands, participants learned to quilt, digital photography, or engaged both activities for an average 16.51 hr week months. Results at posttest indicated memory was enhanced these productive-engagement relative receptive-engagement conditions,...
ABSTRACT Background Neurofilament light chain protein (NfL) is a promising biomarker of neurodegeneration. Objectives To determine whether plasma and CSF NfL (1) associate with motor or cognitive status in Parkinson's disease (PD) (2) predict future decline PD. Methods Six hundred fifteen participants neurodegenerative diseases, including 152 PD 200 healthy control participants, provided and/or cerebrospinal fluid (CSF) sample. Diagnostic groups were compared using the Kruskal−Wallis rank...
Health disparities are pervasive in the United States. In field of Parkinson disease (PD), profound racial and ethnic exist diagnosis, treatment, research participation, leading to differential health outcomes lack generalizable data. Racial not only limit our understanding this complex heterogeneous disorder but also hamper ability provide new evidence-based care for America's most vulnerable populations. report, we summarize findings from comprehensive white paper Michael J. Fox Foundation...
Abstract Background Peer review is essential to the advancement of knowledge. However, training on how conduct peer limited, unorganized, and not well studied. Thus, we sought determine if a structured mentored peer-review program improved as measured by multiple quantitative qualitative assessments. Methods This pre-post intervention study enrolled 55 mentees across 5 cohorts from 2020 2023. Each cohort completed pre-program evaluations, participated in 2 reviews, post-program evaluations...
ABSTRACT Background Dystonia may respond to VMAT2 inhibition. Objectives Providing pilot data on the safety, tolerability, and efficacy of deutetrabenazine in non dopa‐responsive dystonia. Methods Deutetrabenazine was titrated by adults with isolated Primary study endpoints included proportion who maintained individual, maximum tolerated dose for 6 weeks, how many 48 mg/day. Secondary rates QTc prolongation/arrhythmias, suicidality, excessive daytime sleepiness, cognitive decline,...
Abstract Elucidating the genetic contributions to Parkinson’s disease (PD) etiology across diverse ancestries is a critical priority for development of targeted therapies in global context. We conducted largest sequencing characterization potentially disease-causing, protein-altering and splicing mutations 710 cases 11,827 controls from genetically predicted African or admixed ancestries. explored copy number variants (CNVs) runs homozygosity (ROHs) prioritized early onset familial cases....
Caregivers are integral to Parkinson disease (PD) care, but little information exists regarding how caregivers impact patient outcomes.To assess the association between reporting depression symptoms and quality of life (QOL), emergency department (ED) visits, hospitalizations.This retrospective cohort study was conducted at 15 Parkinson's Foundation Centers Excellence within US. The Outcomes Project registry used collect baseline data from January 1, 2016, December 31, 2018, with subsequent...
Current studies of end-of-life care in Parkinson disease (PD) do not focus on diverse patient samples or provide national views resource utilization. We determined sociodemographic and geographic differences inpatient intensity among persons with PD the United States (US).
Idiopathic intracranial hypertension (IIH) disproportionately affects women from socioeconomically disadvantaged communities, but specific social determinants of health have not been examined.
The positive predictive value (PPV) of the
Although neurodegenerative diseases are a leading cause of death, little is known about health care utilization and cost during the end-of-life (EoL) period or how it compares with that other life-limiting conditions. We aimed to describe compare resource among US Medicare decedents cancer.
Abstract This is an inception cohort study protocol to enroll people with Parkinson's disease into a biobanking at the clinic-wide level collecting clinical information and blood for future research use. The informed consent process includes optional recontact studies, access medical record, use of samples studies. Blood products (plasma genomic DNA) are banked Clinical data obtained through questionnaire. Each visit lasts between 10-20 min coordinator patient time their return office....
Observational studies in Parkinson's disease (PD) deeply characterize relatively small numbers of participants. The Molecular Integration Neurological Diagnosis Initiative seeks to molecular and clinical features every PD patient at the University Pennsylvania (UPenn). objectives this study are determine feasibility genetic characterization assess by sex GBA1/LRRK2 status on a clinic-wide scale. All patients with visits UPenn Center between 9/2018 12/2022 were eligible. Blood or saliva...
The objective of this study was to determine if recidivistic Adult Protective Services (APS) cases referred for a decision-making capacity assessment were more cognitively impaired than nonrecidivistic cases. A retrospective medical record review neuropsychological and demographic data gathered during decisional assessments. Recidivistic clients those APS once; with single open case nonrecidivistic. Mean test scores compared between (n = 138) 95) subjects. No significant differences found...
Drug-induced parkinsonism (DIP) can be clinically indistinguishable from degenerative parkinsonism, and bedside assessments are needed to differentiate between these conditions. We examined 34 U.S. Veterans with DIP using 123I-FP-CIT (DAT-SPECT) identify underlying nigrostriatal degeneration. Participants were 94% male mean age of 64.5 ± 7.1 years. DAT-SPECT was abnormal in 12/34 (35%). Comparing normal imaging groups, there no differences age, sex, race/ethnicity, psychiatric diagnosis,...
Fat embolism syndrome (FES) is a known complication of sickle cell disease (SCD) that occurs secondary to vaso-occlusive crises, bone marrow infarction, and the subsequent release fat globules into venous circulation. Although neurologic involvement common, pathophysiology cerebral emboli remains controversial. While microemboli can enter arterial circulation through right-to-left shunts, systemic free fatty acids may also cause indirect endothelial damage disruption blood-brain-barrier. We...
A 65-year-old woman with no significant medical history was brought to the emergency room after experiencing 2 weeks of band-like occipital headaches and days progressive mental status changes. Her neurologic examination for decreased alertness, disorientation time, confabulation, loss recent remote memory, diffuse hyperreflexia, a left Hoffmann sign. MRI brain contrast showed bilateral subdural hygromas, enhancement dura mater, mild sagging brainstem suggestive intracranial hypotension...
The purpose of this study was to determine whether squalor-dwelling Adult Protective Services (APS) clients were more cognitively impaired than non-squalor-dwelling APS referred for decision-making capacity assessments. authors performed a retrospective medical record review neuropsychological and demographic data gathered during decisional Squalor dwelling defined by unsanitary living conditions that posed danger the occupant's health or safety. Mean test scores compared between (n = 50)...
BACKGROUND: Persons with Parkinson disease (PD) have complex care needs that may benefit from enhanced nursing provided in Magnet-designated hospitals. Our primary objective was to determine whether an association exists between hospital Magnet status and patient safety events for PD inpatients the United States. METHODS: We conducted a retrospective cohort study using Nationwide Inpatient Sample Agency Healthcare Research Quality databases 2000 2010. diagnosis demographic variables were...