A5107997461- Parkinson's Disease Mechanisms and Treatments
- Occupational Therapy Practice and Research
- Dementia and Cognitive Impairment Research
- Cerebral Palsy and Movement Disorders
- Cognitive Functions and Memory
- Stroke Rehabilitation and Recovery
- Autism Spectrum Disorder Research
- Neurological disorders and treatments
- Balance, Gait, and Falls Prevention
- Health Policy Implementation Science
- Neurobiology of Language and Bilingualism
- Systemic Lupus Erythematosus Research
- Assistive Technology in Communication and Mobility
- Neural and Behavioral Psychology Studies
- Genetics and Neurodevelopmental Disorders
- Attention Deficit Hyperactivity Disorder
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Community Health and Development
- Endoplasmic Reticulum Stress and Disease
- Elder Abuse and Neglect
- Telemedicine and Telehealth Implementation
- Mental Health and Patient Involvement
- Sphingolipid Metabolism and Signaling
- Intensive Care Unit Cognitive Disorders
Washington University in St. Louis
2016-2025
University of Pittsburgh
2024
University of Michigan
2021
The University of Texas Southwestern Medical Center
2021
American Academy of Neurology
2021
Cornell University
2021
McLaren Regional Medical Center
2008
Importance Episodic memory and executive function are essential aspects of cognitive functioning that decline with aging. This may be ameliorable lifestyle interventions. Objective To determine whether mindfulness-based stress reduction (MBSR), exercise, or a combination both improve in older adults. Design, Setting, Participants 2 × factorial randomized clinical trial was conducted at US sites (Washington University St Louis California, San Diego). A total 585 adults (aged 65-84 y)...
Abstract Clinicopathologic studies of Parkinson disease dementia (PDD) and with Lewy bodies (DLB) commonly reveal abnormal β‐amyloid deposition in addition to diffuse (α‐synuclein aggregates), but the relationship among these neuropathologic features development disorders remains uncertain. The purpose this study was determine whether amyloid‐β detected by PET imaging Pittsburgh Compound B (PIB) distinguishes clinical subtypes body‐associated disorders. Nine healthy controls, 8 PD no...
Prospective memory is a complex cognitive construct ubiquitous in everyday life that thought to sometimes rely on executive skills commonly affected by Parkinson's disease (PD). The present study investigated the effect of PD prospective tasks with varying demand control processes, namely amount strategic attentional monitoring required for intention retrieval. Individuals but without dementia and healthy adults performed laboratory event-based varied whether (nonfocal condition) or...
Abstract OBJECTIVE. To investigate the performance of cognitively demanding instrumental activities daily living (IADLs) among people with Parkinson’s disease (PD) without dementia. METHOD. Seventy-seven participants PD and 57 underwent standardized, performance-based IADL evaluation using Performance Assessment Self-care Skills. Activity was rated for independence, adequacy, safety. RESULTS. The group had lower independence adequacy scores than non-PD almost every activity. Medication...
Individuals with Parkinson disease (PD) who do not have dementia reliably demonstrate mild executive deficits on laboratory-based tests, but the impact of these occupational performance is unclear. The purpose this study was to determine relevance dysfunction in PD without instrumental, leisure, and social activity participation. Twenty-four individuals 30 matched adult volunteers performed an experimental working memory test rated their everyday function Participants had worse performance,...
Objective-This study investigated the effect of Parkinson disease (PD) on event-based prospective memory tasks with varying demand (1) amount strategic attentional monitoring required for intention retrieval (prospective component) and ( 2) retrospective processes to remember contents or entire constellation tasks.Method-Twenty-four older adults PD 28 healthy performed computerized Virtual Week task, a multi-intention paradigm that simulates everyday tasks.The included regular (low demand)...
Based on multi-domain classification of Parkinson disease (PD) subtypes, we sought to determine the key features that best differentiate subtypes and utility PD predict clinical milestones.
Abstract Elucidating the genetic contributions to Parkinson’s disease (PD) etiology across diverse ancestries is a critical priority for development of targeted therapies in global context. We conducted largest sequencing characterization potentially disease-causing, protein-altering and splicing mutations 710 cases 11,827 controls from genetically predicted African or admixed ancestries. explored copy number variants (CNVs) runs homozygosity (ROHs) prioritized early onset familial cases....
Aims This study aims to identify implementation determinants, mechanisms of action, strategies, and outcome evaluation plans for a new theory-based rehabilitation goal setting management intervention system, called MyGoals, using Implementation Mapping with community-based participatory research principles. Methods We completed tasks 1 4 as planning team consisting MyGoals target implementers (occupational therapists (OTs), clients (adults chronic conditions), the team. are currently...
Occupational therapy practitioners address the occupational performance and participation needs of people with Parkinson's disease (PD) their care partners.This Practice Guideline is informed by systematic reviews on use interventions to promote in occupations for PD facilitate caregivers' caregiver role. This guideline meant support practitioners' clinical decision making when working partners.We examined synthesized results four integrated those into recommendations practice.Thirty-three...
Background Although goal setting and management (GSGM) is a key component of chronic disease rehabilitation practice, there currently no widely used evidence-based intervention system available. This paper describes the theoretical underpinnings development new called MyGoals. MyGoals designed to guide occupational therapy (OT) practitioners implement theory-based, client-engaged GSGM for adults with conditions in community-based OT settings. Methods We first developed planning team two...
Purpose: To investigate the feasibility of a novel client-centered cognitive strategy training intervention for people with Parkinson's disease (PD).Materials and methods: This was case series seven PD without dementia but subjective decline. The involved ≥5 treatment sessions at participant's home. Participant acceptance engagement were assessed by Credibility/Expectancy Questionnaire (CEQ), Client Satisfaction (CSQ), enjoyment effort ratings, homework completion. Logistical information...
Mastery of jargon terms is an important part student learning in biology and other science, technology, engineering, mathematics domains. In two experiments, we investigated whether prelecture quizzes enhance memory for terms, that enhanced familiarity can facilitate related concepts are encountered during subsequent lectures readings. Undergraduate students enrolled neuroanatomy physiology courses completed 10-minute low-stakes with feedback on either online (experiment 1) or using in-class...
People with Parkinson disease (PD) commonly experience cognitive decline, which may relate to increased α-synuclein, tau, and β-amyloid accumulation. This study examines whether the different proteins predict longitudinal decline in PD.
Abstract OBJECTIVE. We investigated participation levels and relationships among cognition, depression, for people with severe congestive heart failure (CHF). METHOD. People CHF (New York Heart Association Class III or IV) awaiting transplantation (N = 27) completed standardized tests of cognition self-report measures executive dysfunction, depressive symptoms, participation. RESULTS. Possible depression (64%) cognitive impairment (15%–59%) were prevalent. Participants reported significant...
To explore the potential influence of Stanford Chronic Disease Self-Management Program (CDSMP) on social support in Parkinson disease (PD).This was a quasi-experimental mixed methods design. Volunteers with PD (n=27) and care partners (n=6) completed CDSMP, questionnaires self-management outcomes, an interview about relation to CDSMP participation. participants (n=19) who did not participate for quantitative comparison purposes.Regarding data, there were no significant effects participation...