A5044978160- Cerebrovascular and Carotid Artery Diseases
- Electrospun Nanofibers in Biomedical Applications
- Proteoglycans and glycosaminoglycans research
- Antioxidant Activity and Oxidative Stress
- Periodontal Regeneration and Treatments
- Cardiovascular Function and Risk Factors
- Neurological Disease Mechanisms and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Endoplasmic Reticulum Stress and Disease
- Lipid Membrane Structure and Behavior
- Acute Ischemic Stroke Management
- Vitamin D Research Studies
- Pharmacogenetics and Drug Metabolism
- Traumatic Brain Injury and Neurovascular Disturbances
- Sphingolipid Metabolism and Signaling
- Cardiomyopathy and Myosin Studies
- Olfactory and Sensory Function Studies
- Asthma and respiratory diseases
- Nitric Oxide and Endothelin Effects
- Cardiac electrophysiology and arrhythmias
Semmelweis University
2006-2025
Background/Objectives: Disrupted intracellular calcium (Ca2+i) regulation and renin–angiotensin system (RAS) activation are pathogenetic factors in diabetic cardiomyopathy, a major complication of type 1 (T1D) 2 (T2D) diabetes. This study explored their potential link rat hearts. Methods: Experiments were conducted on T1D T2D Sprague-Dawley rats induced by streptozotocin fructose-rich diet, respectively. In T1D, treated with Enalapril (Ena) or Losartan (Los) for six weeks, whereas animals...
Carotid artery stenosis (CAS) affects approximately 5–7.5% of older adults and is recognized as a significant risk factor for vascular cognitive impairment (VCI). The impact CAS on cerebral blood flow (CBF) within the ipsilateral hemisphere relies adaptive capabilities microcirculation. In this study, we aimed to test hypothesis that impaired availability nitric oxide (NO) compromises CBF homeostasis after unilateral carotid occlusion (CAO). To investigate this, three mouse models exhibiting...
Hyaluronic acid (HA) is an ideal initial material for preparing hydrogels, which may be used as scaffolds in soft tissue engineering based on their advantageous physical and biological properties. In this study, two crosslinking agents, divinyl sulfone (DVS) butanediol diglycidyl ether, were to investigate effect the properties of HA hydrogels. As hydrogels alone do not promote cell adhesion scaffold, fibrin serum from platelet-rich (SPRF) combined with scaffold; aim was create a intended...
Vitamin D insufficiency has been associated with increased incidence and severity of cerebrovascular disorders. We analyzed the impact impaired vitamin signaling on anatomical functional aspects adaptation to unilateral carotid artery occlusion (CAO), a common consequence atherosclerosis cause ischemic stroke. Cerebrocortical blood flow (CoBF) showed significantly drop delayed recovery after CAO in mice carrying functionally inactive receptor (VDR) most sustained perfusion deficit temporal...
The present research aimed to characterize soft tissue implants that were prepared with the use of crosslinked hyaluronic acid (HA) using two different crosslinkers and multiple reagent concentrations, alone or in combination fibrin. effect was evaluated an vivo mouse model, after 4 weeks one group 12 other. explants compared analytical methods, evaluating microscopic images, a histology analysis. kinetics degradation remodeling found be greatly dependent on concentration type crosslinker;...
Sphingosine-1-phosphate (S1P) has been implicated recently in the physiology and pathology of cardiovascular system including regulation vascular tone. Pilot experiments showed that vasoconstrictor effect S1P was enhanced markedly presence phenylephrine (PE). Based on this observation, we hypothesized might modulate α1-adrenergic vasoactivity. In murine aortas, a 20-minute exposure to but not its vehicle increased Emax decreased EC50 PE-induced contractions indicating hyperreactivity...
Pharmacogenomics, a fascinating, emerging area of biomedical research is strongly influenced by growing availability genomic databases, high-through-put technologies, bioinformatic tools and artificial computational modeling approaches. Multinational clusters, such as the regional internet-driven pharmaco-grids generated an entirely new environment for development in pharmacology. Although field pharmacogenomics its infancy, promise lies potential to predict sources interindividual...
The understanding of cerebral autoregulation has become notable importance due to the increased incidence carotid artery stenosis in elderly population which entails an risk stroke, 2nd most common cause mortality worldwide. Many debates, regarding its exact mechanisms, exist scientific literature including role endothelial and neuronal nitric oxide (NO) synthases (eNOS nNOS) prostanoid mediators (PMs). According our previous observations, eNOS, surprisingly, does not seem play important...
Vitamin D deficiency is a global health problem, which can increase the risk of cerebrovascular diseases including ischaemic stroke. However, pathophysiological mechanism underlying this association not well understood yet. The goal present work was to examine impacts vitamin on mouse pial collateral circulation might provide compensatory pathway after unilateral common carotid artery occlusion (CAO). morphology leptomeningeal collaterals and distance anastomotic line (half between nearest...