A5052782397- Lipoproteins and Cardiovascular Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Cardiovascular Disease and Adiposity
- SARS-CoV-2 detection and testing
- Neuroscience and Neuropharmacology Research
- Blood Coagulation and Thrombosis Mechanisms
- Retinopathy of Prematurity Studies
- Phagocytosis and Immune Regulation
- Cardiovascular Health and Disease Prevention
- Renal Diseases and Glomerulopathies
- Ion channel regulation and function
- Barrier Structure and Function Studies
- Renal and Vascular Pathologies
- Health, Environment, Cognitive Aging
- Genetic Associations and Epidemiology
- Ocular Surface and Contact Lens
- Immune Response and Inflammation
- Ophthalmology and Eye Disorders
- Children's Physical and Motor Development
Smith-Kettlewell Eye Research Institute
2022-2024
Massachusetts Eye and Ear Infirmary
2022-2024
Harvard University
2022-2024
University of Massachusetts Chan Medical School
2024
Cleveland Clinic
2024
University of California, Berkeley
2019-2021
Mater Misericordiae University Hospital
1989-2017
GTx (United States)
2003
Abstract Systematic SARS-CoV-2 testing is a valuable tool for infection control and surveillance. However, broad application of high sensitive RT-qPCR in children often hampered due to unpleasant sample collection, limited capacities costs. Here, we developed high-throughput approach (‘Lolli-Method’) detection children, combining non-invasive collection with an RT-qPCR-pool strategy. infections were diagnosed sensitivities 100% 93.9% when viral loads >10 6 copies/ml 3 corresponding...
The role of glia, particularly astrocytes, in mediating the central nervous system's response to injury and neurodegenerative disease is an increasingly well studied topic. These cells perform myriad support functions under physiological conditions but undergo behavioral changes - collectively referred as 'reactivity' disruption neuronal homeostasis from insults, including glaucoma. However, much remains unknown about how reactivity alters progression both beneficially detrimentally whether...
Screening for concomitant atherosclerotic disease is important in cardiovascular risk reduction. This study assessed the prevalence of carotid artery (CAD) and peripheral arterial (PAD) patients with known abdominal aortic aneurysms (AAAs). All AAA attending vascular laboratory between January 1, 2007, December 31, 2009, were eligible a ultrasound measurement ankle brachial indices. A total 389 (305 males) identified on surveillance program mean (±standard deviation) age 76 (±8) years. The...
Abstract Astrocyte heterogeneity is an increasingly prominent research topic, and studies in the brain have demonstrated substantial variation astrocyte form function, both between within regions. In contrast, retinal astrocytes are not well understood remain incompletely characterized. Along with optic nerve astrocytes, they responsible for supporting ganglion cell axons improved understanding of their role required. We used a combination microdissection Ribotag immunoprecipitation to...
Glaucoma is a common neurodegenerative disease characterized by progressive degeneration of retinal ganglion cells (RGCs) and the nerve fiber layer (RNFL), resulting in gradual decline vision. A recent study our groups indicated that levels lipoxins
Abstract Background Youth with intellectual disabilities experience disparities in physical activity and diet quality. Physical food literacy are hypothesised to support adoption of healthy lifestyles; however, few such interventions have been developed for this population. Method Participants ages 12–16 years were recruited a 12‐week online sports skills nutrition education intervention. Feasibility, acceptability, preliminary efficacy assessed by attendance, satisfaction, pre‐post measures...
A 36-year-old man with Marfan syndrome underwent mitral surgery after personalized external aortic root support operation. Redo was performed without cannulation (with right axillary and retrograde cardioplegia). Surgical findings revealed unique changes adventitial growth vasa vasorum, visible mesh. Further research is crucial to optimize surgical strategies outcomes.
Astrocytes are a major category of glial support cell in the central nervous system and play variety essential roles both health disease. As our understanding diverse functions these cells improves, extent heterogeneity between astrocyte populations has emerged as key area research. Retinal astrocytes, which form direct cellular environment retinal ganglion somas axons, undergo reactive response human glaucoma animal models disease, yet their contributions to its pathology progression remain...
Abstract Systematic SARS-CoV-2 testing is a valuable tool for infection control and surveillance. However, broad application of high sensitive RT-qPCR in children often hampered due to unpleasant sample collection, limited capacities costs. Here, we developed high-throughput approach (‘Lolli-Method’) detection children, combining non-invasive collection with an RT-qPCR-pool strategy. infections were diagnosed sensitivities 100% 93.9% when viral loads >10 6 copies/ml 3 corresponding...
Tiefe Venenthrombosen sind nicht selten, und die Untersuchung einer Gerinnungsneigung oder Thrombophilie gehört zu den häufigsten Anforderungen an das medizinische Labor. Auf diesem komplexen Gebiet ergibt sich Diagnose neben der Klinik oft aus einem Wechselspiel zwischen gerinnungsphysiologischen Funktionstests, biochemischen Analysen molekulargenetischen Untersuchungen. So steht Aufklärung exemplarisch für Rolle Molekulargenetik in Labormedizin. Ziel vorliegenden Übersicht ist es,...
Deep vein thrombosis is not a rare medical condition, and the investigation of clotting disposition or thrombophilia one most common tasks required laboratory.In this complex approach, diagnosis achieved on basis clinical features backed up by combination investigations function, biochemical analyses, genetic tests.Therefore, represents as good example role molecular testing in laboratory medicine.The aim present review to outline current state art investigating with particular reference...