A5100624105- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Neurobiology and Insect Physiology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Ubiquitin and proteasome pathways
- Natural product bioactivities and synthesis
- Plant Virus Research Studies
- Extracellular vesicles in disease
- Lipid metabolism and biosynthesis
- Cancer-related Molecular Pathways
- Genomics and Phylogenetic Studies
- RNA Research and Splicing
- Eicosanoids and Hypertension Pharmacology
- Biochemical Acid Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Phytochemical and Pharmacological Studies
- Circadian rhythm and melatonin
- TGF-β signaling in diseases
- Tissue Engineering and Regenerative Medicine
- Respiratory viral infections research
Institute of Crop Sciences
2021
Chinese Academy of Agricultural Sciences
2021
China Agricultural University
2018-2021
Third Xiangya Hospital
2021
Central South University
2021
China Three Gorges University
2019
First Affiliated Hospital of Shihezi University Medical College
2018
Shihezi University
2017
Abstract Ligusticum L . , one of the largest members in Apiaceae, encompasses medicinally important plants, taxonomic statuses which have been proved to be difficult resolve. In current study, complete chloroplast genomes seven crucial plants best-known herbs were presented. The ranged from 148,275 148,564 bp length with a highly conserved gene content, order and genomic arrangement. A shared dramatic decrease genome size resulted lineage-specific inverted repeat (IR) contraction, could...
Purpose: Hepatocellular carcinoma (HCC) is the most common malignant tumor of liver cells.Researchers have reported that cancer susceptibility candidate 2 (CASC2), a long non-coding RNA, down-regulated in various cancers, including HCC.Our study aimed to investigate molecular mechanism(s) CASC2 HCC.Materials and Methods: Real-time quantitative PCR (RT-qPCR) was used analyze expression miR-183 HCC tissues cells.The viability SMMC-7721 Huh-7 cells detected through MTT assay.Colony formation...
Abstract Almond is one of the most featured nut crops owing to its high nutritional value. However, due three different waves flower and fruitlet drop, fruit drop a major concern for growers. In this study, we carried out time-course transcriptome analysis investigate gene expression differences between normal abnormal development. By de novo assembly analysis, identified 33,577 unigenes provided their functional annotations. total, 7,469 differentially expressed genes observed apparent...
NEF is a tumor suppressing long non-coding (lnc)RNA in hepatocellular carcinoma. Based on current literature, the involvement of other human diseases still unknown. The study aimed to investigate potential glioma, which type rare, but aggressive malignancy. It was determined that expression downregulated tissues compared with adjacent heathy tissues. A low blood level patients glioma effectively distinguished from healthy controls who had high levels. Blood levels were significantly...
Mesenchymal stromal/stem cells (MSCs) have been applied in clinical trials with an increasing number recent years. MSCs showed their great potentials regenerative medicine for extensive sources, multilineage differentiation potential, low immunogenicity and self-renewal ability. However, the application of still confronts many challenges including requirement large quantity cells, survival ability vivo loss main original characteristics due to two-dimensional (2D) culture although it is...
Circadian clocks control daily rhythms in physiology, metabolism and behaviour most organisms. Proteome‐wide analysis of protein oscillations is still lacking Drosophila . In this study, the total phosphorylated heads a 24‐h time‐course were assayed by using isobaric tags for relative absolute quantitation (iTRAQ) method, 10 7 oscillating proteins as well 19 22 phosphoproteins w 1118 Clk Jrk mutant strains separately identified. Lastly, we performed mini screen to investigate functions some...
Sleep is a crucial factor for health and survival in all animals. In this study, we found by proteomic analysis that some cancer related proteins were impacted the circadian clock. The 14-3-3ε protein, expression of which activated transcription Clock, regulates adult sleep Drosophila independent rhythm. Detailed regulatory mechanism shows directly targets Ultrabithorax (Ubx) gene to activate pigment dispersing (PDF). dopamine receptor (Dop1R1) octopamine (Oamb), are also involved pathway,...
Following the publication of this paper, it was drawn to Editors' attention by a concerned reader that certain scratch‑wound assay data shown in Fig. 5A and Transwell cell migration 5B were strikingly similar appearing different form other articles authors. Owing fact contentious above article had already been published elsewhere, or under consideration for publication, prior its submission <em>Experimental Therapeutic Medicine</em>, Editor has decided paper should be retracted from Journal....
Objective To explore the effect of microRNA(miRNA, miR)- 200c in reversing chemo- resistance human pancreatic cancer stem cells. Methods CD24+ CD44+ ESA+ cells were sorted from PANC- 1 cell line by FACS.miR-200c precursor fragment and negative control transfected into cells. The real- time fluorescent quantitative polymerase chain reaction(FQ- PCR)was used to detect miR-200c expression.MTT assay was measure drug sensitivity gemcitabine. Results CD24+ cells(0.8%) isolated...
Objective To investigate the sensitivity of human pancreatic cancer stem cells to chemotherapy and expression microRNA(miRNA, miR)- 200c in cells. Methods CD24+ CD44+ ESA+ were sorted from PANC- 1 cell line by fluorescence- activated sorter(FACS).The like properties this subpopulation assessed non- obese diabetic (NOD)/severe combined immunodeficiency(SCID) xenograft transplantation experiment.Sensitivity gemcitabine apoptosis ratio detected methyl thiazol tetrazolium(MTT)assay FACS...
Objective To examine prevalence characteristics and pathogenic spectrum of fever with respiratory syndrome in Liaoning province to provide a basis for clinical diagnosis prevention control the syndrome.Methods Medical records throat swab specimens cases were collected at 10 sentinel hospitals 8 cities from 2012 through 2014.Influenza virus (Flu),parainfluenza (PIA),respiratory adenovirus (Adv),respiratory syncytial (RSV),human coronavirus (HCov),human rhinovirus (HRV),and human...