A5039886115- Microfluidic and Capillary Electrophoresis Applications
- Microfluidic and Bio-sensing Technologies
- Nanopore and Nanochannel Transport Studies
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Electrowetting and Microfluidic Technologies
- Analytical Chemistry and Sensors
- Lung Cancer Treatments and Mutations
- Gold and Silver Nanoparticles Synthesis and Applications
- Acute Myeloid Leukemia Research
- Surface Modification and Superhydrophobicity
- DNA and Biological Computing
- 3D Printing in Biomedical Research
- Modular Robots and Swarm Intelligence
- Cardiovascular Function and Risk Factors
- Extracellular vesicles in disease
- Chronic Myeloid Leukemia Treatments
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Chronic Lymphocytic Leukemia Research
- RNA and protein synthesis mechanisms
- Lymphoma Diagnosis and Treatment
- Advanced Biosensing Techniques and Applications
- Cancer Treatment and Pharmacology
- Innovative Microfluidic and Catalytic Techniques Innovation
Korea University
2015-2024
Westchester Medical Center
2018
University of North Carolina at Chapel Hill
2008-2017
Catholic University of America
2014
Seoul National University
1999-2010
Advanced Institute of Convergence Technology
2010
Catholic University of Korea
2009
Georgetown University Medical Center
2007
Georgetown University
2007
Rocky Mountain Cancer Centers
2007
5-Fluorodeoxyuridine (FUDR) was infused continuously into the hepatic artery for 14 days a month at an initial dose of 0.3 mg/kg per day in 45 patients with liver metastases from colorectal carcinoma. In 41 adequately treated patients, partial responses (greater than 50% tumor regression) were observed 12 (52%) 23 previously untreated and three (17%) 18 patients. Severe gastrointestinal toxicity endoscopically documented 19 (46%) patients; (29%) had discrete ulcers, seven diffuse gastritis...
Electrical stimulation (ES) is known to guide the development and regeneration of many tissues. However, although preclinical clinical studies have demonstrated superior effects ES on cartilage repair, chondrogenesis remain elusive. Since mesenchyme stem cells (MSCs) high therapeutic potential for regeneration, we investigated actions during MSCs. Herein, demonstrate first time that enhances expression levels chondrogenic markers, such as type II collagen, aggrecan, Sox9, decreases I...
Abstract New storage technologies are needed to keep up with the global demands of data generation. DNA is an ideal medium due its stability, information density and ease-of-readout advanced sequencing techniques. However, progress in writing stifled by continued reliance on chemical synthesis methods. The enzymatic a promising alternative, but thus far has not been well demonstrated parallelized manner. Here, we report multiplexed method using maskless photolithography. Rapid uncaging Co 2+...
Abstract Extracellular vesicles (EVs) are the cell-secreted nano- and micro-sized particles consisted of lipid bilayer containing nucleic acids proteins for diagnosis therapeutic applications. The inherent complexity EVs is a source heterogeneity in various potential applications biological nanovesicles including analysis. To diminish heterogeneity, EV should be isolated separated according to their sizes cargos. However, current technologies do not meet requirements. We showed noninvasive...
PURPOSE To provide fludarabine to physicians for the management of patients with advanced refractory chronic lymphocytic leukemia (CLL) and determine response rate duration, toxicity, survival this agent. PATIENTS AND METHODS This phase II protocol was open all eligible whose local obtained written permission from National Cancer Institute (NCI) register onto protocol. Of 791 national international enrolled patients, 724 a median age 65 years received fludarabine, which 703 were assessable...
The development and analysis of a microfluidic sample preconcentration system using highly ion-conductive charge-selective polymer [poly-AMPS (2-acrylamido-2-methyl-1-propanesulfonic acid)] is reported. based on the phenomenon concentration polarization which develops at boundaries poly-AMPS with buffer solutions. A negatively charged polymer, poly-AMPS, positioned between two microchannels efficiently extracts cations through its large cross section, resulting in efficient anion...
Dopamine (DA), a vital neurotransmitter, plays critical role in the human brain and relates to neuropsychiatric disorders such as Parkinson's disease schizophrenia. Numerous studies have explored detection of biomarkers through surface-enhanced Raman spectroscopy (SERS). However, most focused on SERS face significant challenges with plasmonic nanostructure development. Such often include time-consuming processes, complex fabrication, specialized chemical labeling, poor reproducibility,...
SAW-aggregated gold nanoparticles as SERS substrates for detecting surface-adsorbent toxic substances on microplastics.
This paper reports a polyelectrolytic salt bridge-based electrode (PSBE), which is key embedded unit in microchip device that can size-selectively count microparticles and measure their velocities. The construction of bridges at specific locations within microfluidic chip enables dc-driven electrical detection to be performed successfully. expected competitive alternative the optical methods currently used conventional cell sorters. PSBEs were fabricated by irradiating ultraviolet light over...
Abstract CRISPR-based screening methods using single-cell RNA sequencing (scRNA-seq) technology enable comprehensive profiling of gene perturbations from knock-out mutations. However, evaluating substitution mutations scRNA-seq is currently limited. We combined CRISPR RNA-guided deaminase and to develop a platform for introducing in multiple genes assessing the mutation-associated signatures. Using this platform, we generated library consisting 420 sgRNAs, performed sgRNA tracking analysis,...
A novel electrical DNA biosensor is presented, which consists of gold (Au) nanoscale islands and a single-walled carbon nanotube (SWCNT) network on top concentric Au electrode array (also referred to as the CGi). The decorated SWCNT provide ideal docking sites for ss-DNA probe (p-DNA) molecules. They also better adhesion between chip substrate. In addition, gives asymmetric current voltage characteristics in solution provides more flexible bias options electrodes. sensor system applied after...
In artificial biological circulation systems such as extracorporeal membrane oxygenation, surface wettability is a critical factor in blood clotting problems. Therefore, to prevent from clotting, omniphobic surfaces are required repel both hydrophilic and oleophilic liquids reduce friction. However, most have been fabricated by combining chemical reagent coating physical structures and/or using rigid materials silicon metal. It almost impossible for chemicals be used the biomedical devices...
We report on a low voltage, straight/smooth surface, and efficient active micromixer. The mixing principle is based alternative ion depletion-enrichment using pair of positively charged polyelectrolytic gel electrodes (pPGEs), which face each other joined by microchannel. This system has an external AC signal source electrically connected to the pPGEs via respective 1 M KCl solutions Ag/AgCl electrodes. When electric bias applied between two pPGEs, anions are extracted through one create...
Abstract Nanoporous membranes have a variety of applications, one which is the size‐selective separation nanoparticles. In drug delivery, nanoporous are becoming increasingly important for isolation exosomes, bio‐nanoparticles. However, low pore density and thickness commercial limit their efficiency. There been many attempts to fabricate sub‐micrometer thin membranes, but limited surface area has restricted practicality. this study, large‐area silicon nitride nanosieves enhanced...
An optofluidic maskless photopolymerization process was developed for in situ negatively charged nanoporous hydrogel [poly-AMPS (2-acrylamido-2-methyl-1-propanesulfonic acid)] fabrication. The lithography system, which combines a high power UV source and digital mirror device, enables fast polymerization of arbitrary shaped hydrogels microfluidic device. poly-AMPS structures were positioned near the intersections two microchannels, used as cation-selective filter biological sample...
In this paper, we investigate the effect of electrical pulse bias on DNA hybridization events in a biosensor platform, using Carbon Nanotube Network (CNN) and Gold Nano Particles (GNP) as an channel. The scheme provides both rate enhancement bio molecules, measurement transient state to avoid charge screening effect, thereby significantly improving sensitivity. As example, probe molecules oscillate with trains, resulting efficiency, accordingly sensor performances Tris–EDTA (TE) buffer...