Saad Serfraz

ORCID: 0000-0001-8187-8226
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About
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Research Areas
  • Plant Virus Research Studies
  • Plant-Microbe Interactions and Immunity
  • Cancer, Lipids, and Metabolism
  • Plant and Fungal Interactions Research
  • Plant Pathogenic Bacteria Studies
  • Legume Nitrogen Fixing Symbiosis
  • Bladder and Urothelial Cancer Treatments
  • Genomics and Phylogenetic Studies
  • Plant pathogens and resistance mechanisms
  • Genetic and Environmental Crop Studies
  • Photosynthetic Processes and Mechanisms
  • Agricultural pest management studies
  • Nitrogen and Sulfur Effects on Brassica
  • Study of Mite Species
  • Agronomic Practices and Intercropping Systems
  • Genomics, phytochemicals, and oxidative stress
  • Animal Disease Management and Epidemiology
  • Chromosomal and Genetic Variations
  • Advanced Breast Cancer Therapies
  • Diet and metabolism studies
  • Insect-Plant Interactions and Control
  • Cocoa and Sweet Potato Agronomy
  • Plant Disease Resistance and Genetics
  • Metabolomics and Mass Spectrometry Studies
  • Transgenic Plants and Applications

University of Agriculture Faisalabad
2022-2025

University of Faisalabad
2022-2024

Genetic Improvement and Adaptation of Mediterranean and Tropical Plants
2019-2021

Centre de Coopération Internationale en Recherche Agronomique pour le Développement
2021

Agropolis International
2021

National Institute for Biotechnology and Genetic Engineering
2015-2017

The Oleaceae family, encompassing key genera such as Fraxinus (ash trees), Olea (olives), Jasminum (jasmine), Syringa (lilac), and Forsythia, plays a crucial ecological economic role. Despite their importance, the evolutionary dynamics immune system adaptations of NLR (Nucleotide binding leucine-rich repeats) gene family remain largely unexplored. This study employs high-throughput comparative genomics to investigate evolution across family. genus is widely distributed both New Old Worlds,...

10.1186/s12870-025-06233-2 article EN cc-by-nc-nd BMC Plant Biology 2025-02-26

Crop wild relatives contain a greater variety of phenotypic and genotypic diversity compared to their domesticated counterparts. Trifolium crop species have limited genetic cope with biotic abiotic stresses due artificial selection for consumer preferences. Here, we investigated the distribution evolution nucleotide-binding site leucine-rich repeat receptor (NLR) genes in genus objective identify reference NLR genes. We identified 412, 350, 306, 389 241 were from Trifolium. subterraneum, T....

10.3390/genes14040867 article EN Genes 2023-04-04

Dalbergioid is a large group within the family Fabaceae that consists of diverse plant species distributed in distinct biogeographic realms. Here, we have performed comprehensive study to understand evolution nucleotide-binding leucine-rich repeats (NLRs) gene Dalbergioids. The families this affected by common whole genome duplication occurred approximately 58 million years ago, followed diploidization often leads contraction. Our suggests since diploidization, NLRome all groups Dalbergioids...

10.3390/genes14020377 article EN Genes 2023-01-31

Endogenous viral elements (EVEs) are widespread in plant genomes. They result from the random integration of sequences into host genomes by horizontal DNA transfer and have potential to alter gene expression. We performed a large-scale search for co-transcripts including caulimovirid 1,678 230 algal species characterized 50 45 distinct belonging lycophytes, ferns, gymnosperms angiosperms. found that insertion badnavirus EVEs along with Ty-1 copia mobile occurred late blight resistance ( R1 )...

10.3389/fpls.2021.683681 article EN cc-by Frontiers in Plant Science 2021-07-23

Vigna is a unique genus that consist of multiple crop species are domesticated in parallel fashion between 7–10 thousand years ago. Here we studied the evolution nucleotide-binding site leucine-rich repeat receptor (NLR) genes across five Vigna. In total identified 286, 350, 234, 250, 108 and 161 NLR were from Phaseolous vulgaris, unguiculata, mungo, radiata, angularis umbellata respectively. Comprehensive phylogenetic clusterization analysis reveals presence seven subgroups Coiled coil like...

10.3390/genes14061129 article EN Genes 2023-05-23

Abstract Whitefly transmitted begomoviruses (family Geminiviridae ) are the major reason for significant yield losses of dicotyledonous crops in tropics and subtropics. Okra ( Abelmoschus esculentus is one important vegetable crops, leaf curl disease caused by geminiviruses most limiting factor its production Pakistan. Here, we report a new species okra‐infecting begomovirus south‐eastern region Pakistan name enation virus OELC uV) complex proposed. This okra uD) found to be associated with...

10.1111/jph.12373 article EN Journal of Phytopathology 2015-02-05

Abstract Arachis hypogaea is an allotetraploid crop widely grown in the world. Wild relatives of genus are rich source genetic diversity and high levels resistance to combat pathogens climate change. The accurate identification characterization plant gene, nucleotide binding site leucine repeat receptor (NLRs) substantially contribute repertoire resistances improve production. In current study, we have studied evolution NLR genes performed their comparative genomics among four diploids ( A....

10.1038/s41598-023-36302-1 article EN cc-by Scientific Reports 2023-06-08

Plant, animal and protist genomes often contain endogenous viral elements (EVEs), which correspond to partial sometimes entire that have been captured in the genome of their host organism through a variety integration mechanisms. While number sequenced eukaryotic is rapidly increasing, annotation characterization EVEs remains largely overlooked. derive from members family Caulimoviridae are widespread across tracheophyte plants, they occur very high copy numbers. However, existing programs...

10.1186/s13100-022-00288-w article EN cc-by Mobile DNA 2022-12-03

Whole genome duplication plays a significant role in plant evolution by providing raw materials that can be modified natural or artificial selection. Nucleotide binding site leucine rich repeat receptor (NLRs) like other gene families are clusters of genes created and their size reflects the number duplicated genes. NLR encode immune receptors facilitate identification effector compounds produced pathogen as part triggered immunity (ETI). The accurate characterization substantially...

10.1016/j.stress.2023.100254 article EN cc-by-nc-nd Plant Stress 2023-10-18

Non-muscle invasive bladder cancer (NMIBC) refers to a subtype of carcinoma where is localized in the inner lining bladder. NMIBC consider as one most costly malignancy and requires significant surgical therapeutic measure. However, recurrence progression tumor common treated patients. Here we presented an integrated OMICs approach for identification inhibition specific genes. We utilized case study three group patients were compared: 1) Relapsed tumors 2) recurrent 3) progression. Common...

10.1080/07391102.2024.2302343 article EN Journal of Biomolecular Structure and Dynamics 2024-01-21

Within the family Fabaceae , genus Glycine is composed of two subgenera annuals (2n=40) and perennials. This life strategy transition may have differentially affected evolution various gene families. Its cultivated species G. max has high level susceptibility to major pathogens including viruses, bacteria fungi. Understanding nucleotide-binding domain leucine-rich repeat ( NLR ) genes in soybean paramount importance due their central role plant immunity potential improving disease resistance...

10.3389/fpls.2024.1383135 article EN cc-by Frontiers in Plant Science 2024-07-09

Non-muscle invasive bladder cancer (NMIBC) is one of the most common type cancer. Here, we have utilized an integrated transcriptomic-computational approach to identify alternate treatments NMIBC. In this study, performed comprehensive comparative analysis between three groups 36 patients with non-relapsed (NR), recurrence and progressive symptoms. Differentially expressed genes involved in pathways associated NMIBC were identified.

10.1080/07391102.2023.2280914 article EN Journal of Biomolecular Structure and Dynamics 2023-11-14

Whole genome duplication plays a significant role in plant evolution by providing raw materials that can be modified natural or artificial selection. Nucleotide binding site leucine rich repeat receptor (NLRs) like other gene families are clusters of genes created and their size reflects the number duplicated genes. The accurate identification characterization NLR substantially contributes to repertoire resistance improves production. ancestors Fabaceae family have underwent whole (WGD)...

10.2139/ssrn.4510816 preprint EN 2023-01-01
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