A5076646244- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Genomic variations and chromosomal abnormalities
- Congenital heart defects research
- Williams Syndrome Research
- Cognitive Abilities and Testing
- Behavioral and Psychological Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Chromosomal and Genetic Variations
- Child Nutrition and Feeding Issues
- Epigenetics and DNA Methylation
- Child Development and Digital Technology
- Hospital Admissions and Outcomes
- Genomics and Rare Diseases
- Prenatal Screening and Diagnostics
- Family and Disability Support Research
- Oral microbiology and periodontitis research
- HIV/AIDS oral health manifestations
- Attention Deficit Hyperactivity Disorder
- Pancreatic function and diabetes
- Data Analysis with R
- Genetic Associations and Epidemiology
- Child and Adolescent Psychosocial and Emotional Development
- Health, Environment, Cognitive Aging
- Lysosomal Storage Disorders Research
Baruch College
2016-2021
New York University
2008-2015
University School
2015
York University
2010-2014
University of Oxford
2013
Yeshiva University
2006-2012
Yale University
1998-2010
IJ Research (United States)
2005-2010
SUNY Downstate Health Sciences University
1989-2010
New York College of Health Professions
2007-2010
Childhood obesity, epidemic in the United States, has been accompanied by an increase prevalence of type 2 diabetes among children and adolescents. We determined impaired glucose tolerance a multiethnic cohort 167 obese
Abstract Reductions in cerebral metabolism sufficient to impair cognition normal individuals also occur Alzheimer's disease (AD). The degree of clinical disability AD correlates closely the magnitude reduction brain metabolism. Therefore, we tested whether impairments tricarboxylic acid (TCA) cycle enzymes mitochondria correlate with disability. Brains were from patients autopsy‐confirmed and dementia ratings (CDRs) before death. Significant ( p < 0.01) decreases occurred activities...
Between January 1995 and November 1998, at Yale-New Haven Hospital, 25 percent of RBCs transfused were processed through prestorage or bedside leukoreduction filters, chosen on a per patient basis (selective [SLR]). July 1999, 30 platelet concentrates (PCs) infused filters. In an attempt to decrease febrile nonhemolytic transfusion reactions (FNHTR), change was made from SLR universal (UPL) for between 1998 December 1999 random donor PCs 2000. FNHTR allergic (ATR) reported 2002 reviewed.For...
The aim of this study was to examine the colonization <i>Streptococcus mutans</i> and sanguinis</i> in oral cavity association with severe early childhood caries (S-ECC). Saliva plaque samples were collected from 14 S-ECC children 8 caries-free (CF) children. All were<i> S. positive; 100% CF 93% positive. children’s severity positively correlated levels <i>S. (p < 0.001), total streptococci 0.01), cultivable bacteria 0.05), age 0.05). Logistic regression...
To evaluate the impact of HIV infection on colonization resistance in proximal gut.It was a case-control study.We contrasted microbiota composition between eight HIV-1-infected patients and HIV-negative controls to characterize community alteration detect exogenous bacteria esophagus, stomach, duodenum, as well mouth using universal 16s ribosomal RNA gene survey correlated findings with serostatus peripheral blood T-cell counts.HIV associated an enrichment Proteobacteria (P=0.020) depletion...
Limited information is available about the effects of HIV and subsequent antiretroviral treatment on host-microbe interactions. This study aimed to determine salivary microbial composition for 10 HIV-seropositive subjects, before 6 months after highly active therapy (HAART), compared with that HIV-seronegative subjects. A conventional culture two culture-independent analyses were used consistently demonstrated differences in among three sets samples. HIV-positive subjects had higher levels...
Retrospective longitudinal studies have noted declines in IQ scores many but not all fra(X) (fragile X) males and females. We report on a prospective investigation of changes cognitive ability (IQ) adaptive behavior (DQ) 24 from four test sites. Individuals who were tested ranged age 3–15 years. To determine ability, administered the Stanford-Binet (4th Edition). assess behavior, evaluated using Vineland Adaptive Behavior Scales. Mean intertest interval was 2.3 Using identical DNA protocols,...
Abstract Recurrent respiratory papillomas are benign airway tumors caused by Human Papillomaviruses (HPVs) types 6 and 11. The disease is characterized multiple recurrences of following surgical removal, activation latent HPV DNA. Most patients have laryngeal disease, while only a small subset has tracheal involvement. We asked whether the lower frequency was due to reduced prevalence latent/subclinical infection or likelihood clinically apparent disease. A total 121 biopsies normal tissues...
Abstract In addition to mental retardation (MR), fragile X [fra(X)] has been associated with other developmental disabilities, autism in particular. Recently, several studies have concluded that the association of fra(X) is at best weak and perhaps nonexistent. This study examined reports previously published data from an epidemiological perspective determine if prevalence among autistic males was significantly different MR males. Nineteen 21 were analyzed 59 examined. Of 5601 tested, 307...
Abstract Since its initial description by Kanner in 1943, the criteria which a diagnosis of autism or autism‐like disorders was made—and their alleged etiologies portrayed—have undergone manifold changes, from psychiatric disorder engendered “refridgerator” parents to neurodevelopmental disability produced main genetic abnormalities. In addition, behavioral characterization has also entered public consciousness and professional domains increasingly past 30 years, effects we are continually...
Studies of age-related features cognitive-behavioral deficits produced by genetic mutations permit us to draw inferences about how brain development may be related cognitive ability as the child ages. Except for Down syndrome (DS) and fragile X mutation (FRAXA), little is known longitudinal changes in individuals with abnormalities producing learning disabilities (LD) or mental retardation (MR). The purpose this prospective study was compare contrast age abilities, adaptive maladaptive...
Late infantile neuronal ceroid lipofuscinosis (LINCL), a pediatric autosomal recessive neurodegenerative lysosomal storage disorder, results from mutations in the CLN2 gene and consequent deficiency tripeptidyl-peptidase I (TPP-I) progressive destruction of neurons. We have previously demonstrated that CNS transfer AAV2CUhCLN2 (an AAV2-based vector expressing human cDNA) rats nonhuman primates mediates long-term TPP-I expression neurons [Sondhi, D., Peterson, D.A., Giannaris, E.L., Sanders,...
Within recent years, numerous individuals have been identified with terminal 4p microdeletions distal to the currently described critical regions for Wolf-Hirschhorn syndrome (WHS). Some of these do not display features consistent WHS whereas others a clinical phenotype some overlap phenotype. In this review we discuss genetic and presentation cases in an attempt understand consequence monosomy genes proposed identify boundary pathogenic involved components
Abstract Wolf–Hirschhorn syndrome (WHS) is a complex congenital malformation produced by loss of genomic material at the locus 4p16.3. In addition to its dysmorphic features, deletion produces range intellectual disability (ID). Many clinical aspects WHS are well‐characterized; however, cognitive‐behavioral characteristics have been rarely examined in systematic fashion. The purpose our study was examine features and compare them children with other subtelomeric deletions that also produce...