A5002257080- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- Medication Adherence and Compliance
- Cancer Treatment and Pharmacology
- Patient Safety and Medication Errors
- Pharmacological Effects and Toxicity Studies
- Acute Myeloid Leukemia Research
- Safe Handling of Antineoplastic Drugs
- Pharmacovigilance and Adverse Drug Reactions
- Healthcare Systems and Practices
- Neuroblastoma Research and Treatments
- Cell Adhesion Molecules Research
- Nausea and vomiting management
- Immune Cell Function and Interaction
- Neutropenia and Cancer Infections
- Histone Deacetylase Inhibitors Research
- Mobile Health and mHealth Applications
- CAR-T cell therapy research
- Colorectal Cancer Treatments and Studies
- Glioma Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Epilepsy research and treatment
- Cancer survivorship and care
- Chemotherapy-induced organ toxicity mitigation
- Economic and Financial Impacts of Cancer
AstraZeneca (France)
2020-2023
Institut Gustave Roussy
2012-2022
Université Paris-Saclay
2017-2020
Délégation Paris 5
2008-2018
Université Paris Cité
2008-2018
École des Hautes Études en Santé Publique
2013-2018
Sorbonne Paris Cité
2012-2018
Sorbonne Université
2016-2018
Université Paris-Sud
2018
Laboratoire d'études sur les monothéismes
2018
Chondrocytes cultivated in monolayer rapidly divide and lose their morphological biochemical characteristics, whereas they maintain phenotype for long periods of time when are alginate beads. Because cartilage has a low cellularity is difficult to obtain large quantities, the number available cells often becomes limiting factor studies chondrocyte biology. Therefore, we explored possibility restoring differentiated properties chondrocytes by cultivating them beads after two multiplication...
Immunotherapy is a promising antitumor strategy that can successfully be combined with current anticancer treatment. In this study, arsenic trioxide (As(2)O(3)) was shown to increase the immune response in CT26 colon tumor-bearing mice through modulation of regulatory T cell (T(reg)) numbers. As(2)O(3) induced T(reg)-selective depletion vitro. vivo, injected 1 mg/kg showed significant decrease T(reg)/CD4 ratio and absolute T(reg) count versus controls. exerted effects only immunocompetent...
The emergence of oral delivery in cancer therapeutics is expected to result an increased need for better coordination between all treatment stakeholders, mainly ensure adequate the patient. There significant interest nurse navigation program's potential improve transitions care by improving communication stakeholders and providing personalized organizational assistance patients. use health information technology another strategy aimed at that can be combined with NN program remote patient...
2000 Background: Various interventions aiming to improve a safe use of oral anti-cancer agents have previously been reported. These retrospective studies involved nurse-led follow-up and health technologies. However, the potential impact these combined strategies is limited by lack rigorous methodology. Methods: We performed randomized phase 3 trial comparing an intervention combining NNs mobile application vs. SOC in cancer pts treated with OAA (excluding hormonal therapy) our tertiary...
Oxidative stress plays a role in the regulation of cancer cell metastasis which involves invasion and adhesion that could be supported by ADAM proteins through activities their metalloprotease disintegrin domains. We hypothesized oxidative act induction ADAM9 protein some cells. Indeed, Western blot analysis for performed on A549 cells exposed to H(2) O(2) reveals dose-dependent two (80 68 kDa) correlated with sharp increase protease activity measured supernatant while layer was slightly...
Busulfan is used as part of a conditioning regimen prior to hematopoietic stem cell transplantation for the treatment certain cancers and immune deficiency syndromes. Due its instability in aqueous preparations, busulfan infusion prepared from concentrate has relatively short shelf life once prepared. The purpose this study was identify most suitable storage container temperature maximize therapeutic infusions Busilvex®. Busilvex® 6 mg/mL diluted 0.55 with 0.9 % NaCl aliquots dispensed into...
Serious neurological adverse events (NAE) have occurred during treatment with high-dose thiotepa regimens of children high-risk solid tumours. The objective was to assess the incidence NAE related and identify potential contributing factors that could exacerbate occurrence this neurotoxicity. From May 1987 March 2011, tumours treated were retrospectively identified. Each detected led an independent case analysis. Potential pre-specified univariate/multivariable analyses performed. Three...
The bystander effect (BE) is the ability of malignant cells affected by an anticancer agent to induce damage in neighboring cancer cells. In this study, we showed that it could also affect immune surrounding tumor and interfere with antitumor response. We observed exposure human lung A549 vinorelbine induced a BE on peripheral blood mononuclear (PBMCs) vitro mice splenocytes vivo. vitro, number PBMCs killed because their coculture vinorelbine-pretreated was 33% higher than those control (p =...
A disintegrin and metalloproteinase 9 (ADAM9) possesses potent metastasis-inducing capacities is highly expressed in several cancer cells. Previous work has shown that ADAM9 participates the adhesive-invasive phenotype lung cells vitro. In this study, we evaluated whether expression plays a critical role metastatic processes vivo angiogenesis. We first found high was correlated with poor adenocarcinoma patient prognosis on Prognoscan data base. model based intravenous injection nude mice...
Cetuximab is crucial in the management of squamous cell carcinoma head and neck patients. Grade 3-4 cetuximab-induced infusion reactions (CI-IRs) occur 2% patients with colorectal cancer. Despite 2.7% CI-IR rate EXTREME trial, higher rates were reported small series (HNSCC) (6%-18%). There an urgent need to better appraise natural history predictive factors for CI-IRs HNSCC exposed cetuximab.The medical records from (n=428) treated by cetuximab at Gustave Roussy January 2013 December 2015...
The development of oral pediatric forms by pharmaceutical companies is still insufficient. In fact, many drugs used in paediatric oncology, such as temozolomide, are not labeled and adapted for use. Temozolomide (TMZ) an alkylating agent the standard care adult brain tumours, neuroblastoma, glioblastoma medulloblastoma. present study was carried out to propose a suitable palatable formulation liquid preparation TMZ. suspension composed TMZ suspended SyrSpend SF pH 4, well crystallization...
ABSTRACT Plasticizer leaching from poly(vinyl chloride) (PVC) tubing is a well‐studied phenomenon and real issue in medical care today. The present study focuses on the release of two plasticizers 1,2‐cyclohexane dicarboxylic acid diisononyl ester (DINCH) (primary) epoxidized soy bean oil (ESBO) (secondary) PVC extension tubings used an oncopediatric unit. calculated by comparison to unused with same batch number. Both DINCH ESBO ratio diminishes versus new tubings. loss has not been related...
Abstract Background Systematic prescription analyses by clinical pharmacists result in pharmacist interventions (PIs) to reduce errors and improve medication safety. PIs are particularly critical oncology, because antineoplastic drugs highly toxic with low therapeutic indexes especially a pediatric population. The aim of this study is describe oncology department identify potential risk factors associated errors. Procedure We conducted 20‐month observational concerning electronic injectable...