A5084058633- Pharmaceutical and Antibiotic Environmental Impacts
- 3D Printing in Biomedical Research
- Spaceflight effects on biology
- Liver physiology and pathology
- Osteoarthritis Treatment and Mechanisms
- Effects and risks of endocrine disrupting chemicals
- Multiple Myeloma Research and Treatments
- Chemistry and Chemical Engineering
- Environmental Toxicology and Ecotoxicology
- Heavy Metal Exposure and Toxicity
- Space Exploration and Technology
- Mesenchymal stem cell research
- Genetics, Aging, and Longevity in Model Organisms
- Water Quality Monitoring and Analysis
- Microfluidic and Capillary Electrophoresis Applications
- Cancer Cells and Metastasis
- Microfluidic and Bio-sensing Technologies
- Trace Elements in Health
- Mercury impact and mitigation studies
- Electrohydrodynamics and Fluid Dynamics
- Environmental Chemistry and Analysis
- RNA Interference and Gene Delivery
- Cellular Mechanics and Interactions
- Medical Imaging and Pathology Studies
- NF-κB Signaling Pathways
University of Brescia
2014-2024
University of Milano-Bicocca
2020
Istituto Neurologico Mediterraneo
2005
National and Kapodistrian University of Athens
2002
École Pratique des Hautes Études
1996-1999
Chondrocytes cultivated in monolayer rapidly divide and lose their morphological biochemical characteristics, whereas they maintain phenotype for long periods of time when are alginate beads. Because cartilage has a low cellularity is difficult to obtain large quantities, the number available cells often becomes limiting factor studies chondrocyte biology. Therefore, we explored possibility restoring differentiated properties chondrocytes by cultivating them beads after two multiplication...
Three-dimensional (3-D) culture models are emerging as invaluable tools in tumor biology, since they reproduce tissue-specific structural features and cell-cell interactions more accurately than conventional 2-D cultures. Multiple Myeloma, which depends on myeloma cell-Bone Marrow microenvironment for development response to drugs, may particularly benefit from such an approach. An innovative 3-D dynamic model based the use of RCCS™ Bioreactor was developed allow long-term tissue explants....
Multiple myeloma is an aggressive tumour able to suppress osteoblastogenesis probably mediated by bone marrow mesenchymal stromal cells (BM-MSCs) that can also support plasma cell growth/survival. The use of MSCs for multiple therapy a controversial topic because the contradictory results on capacity inhibit or promote cancer growth. Our previous studies demonstrated could be loaded with Paclitaxel (PTX) and used deliver drug in situ amount affecting growth (in vitro vivo). Therefore,...
We have previously shown that long-term thyroxine administration can protect the heart against ischemia. In present study, we investigated whether thyroxine-induced cardioprotection mimic pattern of protection is afforded by a well-established cardioprotective means such as ischemic preconditioning. Langendorff-perfused rat preparation, after an initial stabilization, normal and thyroxine-treated hearts were subjected to 20 minutes zero-flow global ischemia followed 45 reperfusion. hearts,...
We propose a human-derived neuro-/glial cell three-dimensional in vitro model to investigate the effects of microgravity on cell-cell interactions. A rotary cell-culture system (RCCS) bioreactor was used generate modelled environment, and morphofunctional features glial-like GL15 neuronal-like SH-SY5Y cells individual cultures (monotypic aggregates) cocultures (heterotypic were analysed. Cell survival maintained within all aggregates over 2 weeks culture. Moreover, compared as traditional...
The process of identifying and approving a new drug is time-consuming expensive procedure. One the biggest issues to overcome risk hepatotoxicity, which one main reasons for withdrawal from market. While animal models are gold standard in preclinical testing, translation results into therapeutic intervention often ambiguous due interspecies differences hepatic metabolism. discovery human induced pluripotent stem cells (hiPSCs) their derivatives has opened possibilities testing. We used...
Three-dimensional (3-D) culture models are emerging as invaluable tools in tumor biology, since they reproduce tissuespecific structural features and cell-cell interactions more accurately than conventional 2-D cultures.Multiple Myeloma, which depends on myeloma cell-Bone Marrow microenvironment for development response to drugs, may particularly benefit from such an approach.An innovative 3-D dynamic model based the use of RCCS TM Bioreactor was developed allow long-term tissue...
The assessment of the actual impact discharged wastewater on whole ecosystem and, in turn, human health requires execution bioassays. In effect, based chemical characterization alone, synergistic/antagonistic effect mixtures pollutants is hardly estimable. aim this work was to evaluate applicability a battery bioassays and suggest smart procedure for results representation. Two real treatment plants were submitted analytical campaigns. Several baseline toxicity assays conducted, together...
Removal potential of many EDCs by conventional WWTPs is recognized. Nevertheless, in order to reach very low concentrations, further treatment (e.g., chemical oxidation) might be required. In this work, two estrogen-like substances were considered: nonylphenol (NP) (and its parent compounds) and bisphenol A (BPA). The experimental work was conducted at Verona (Northern Italy) WWTP (370,000 p.e.): the effluent submitted ozonation a pilot scale plant. Beside microbiological analyses,...
The rapid development of three-dimensional (3D) culture systems and engineered cell-based tissue models gave rise to an increasing need new techniques, allowing the microscopic observation cell behavior/morphology in tissue-like structures, as clearly signalled by several authors during last decennium. With samples consisting small aggregates isolated cells grown suspension, it is often difficult produce optimal embedded preparation that can be further successfully processed for classical...