A5047255645- Genomic variations and chromosomal abnormalities
- Eosinophilic Disorders and Syndromes
- Fibroblast Growth Factor Research
- Genomics and Chromatin Dynamics
- Genetics and Neurodevelopmental Disorders
- Genetics, Aging, and Longevity in Model Organisms
- BRCA gene mutations in cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Cancer Genomics and Diagnostics
- Acute Myeloid Leukemia Research
- Histiocytic Disorders and Treatments
- Developmental Biology and Gene Regulation
- Circadian rhythm and melatonin
- Pancreatic and Hepatic Oncology Research
- Chromatin Remodeling and Cancer
- Genetic factors in colorectal cancer
- Chromosomal and Genetic Variations
- Cancer-related Molecular Pathways
- PARP inhibition in cancer therapy
- Chronic Myeloid Leukemia Treatments
- DNA Repair Mechanisms
- Corneal Surgery and Treatments
- CRISPR and Genetic Engineering
- Platelet Disorders and Treatments
Centre de Recherche en Cancérologie de Marseille
1999-2025
Aix-Marseille Université
2014-2025
Institut Paoli-Calmettes
2002-2024
Institut Pprime
2000-2022
Inserm
2003-2020
Economic & Social Sciences, Health Systems & Medical Informatics
2020
Institut de Recherche pour le Développement
2020
Centre National de la Recherche Scientifique
2016
Hôpital de la Timone
2009-2014
Assistance Publique Hôpitaux de Marseille
2010-2014
Breast cancer is a complex and heterogeneous disease at the molecular level. Evolution difficult to predict according classical histoclinical prognostic factors. Different studies highlight importance of large-scale expression analyses improve taxonomy breast classification. Identification new markers that refine this patient management priority in field research.Nectins are cell adhesion molecules involved regulation epithelial physiology. We present here Nectin-4/PVRL4 as histological...
Chromosome 8p11–12 is the site of a recurrent breakpoint in myeloproliferative disorder that involves lymphoid (T- or B-cell), myeloid hyperplasia and eosinophilia, evolves toward acute leukemia. This multilineage involvement suggests malignant transformation primitive hematopoietic stem cell. In this disorder, region associated with three different partners 6q27, 9q33, 13q12. We describe here molecular characterization t(8;13) translocation FGFR1 gene from 8p12, encoding tyrosine kinase...
Abstract Luminal B breast cancers represent a fraction of oestrogen receptor (ER)‐positive tumours associated with poor recurrence‐free and disease‐specific survival in all adjuvant systemic treatment categories including hormone therapy alone. Identification specific signalling pathways driving luminal biology is paramount to improve treatment. We have studied 100 by combined analysis genome copy number aberrations gene expression. show that amplification the ZNF703 gene, located...
Fibroblast growth factors (FGF) are associated with multiple developmental and metabolic processes in triploblasts, perhaps also diploblasts. The evolution of the FGF superfamily has accompanied major morphological functional innovations metazoan species. study FGFs throughout species shows that can be subdivided eight families present-day organisms evolved through phases gene duplications losses. At least two expansions recognized: a first expansion increased number from one or few...
The benefit of precision medicine based on relatively limited gene sets and often-archived samples remains unproven. PERMED-01 (NCT02342158) was a prospective monocentric clinical trial assessing, in adults with advanced solid cancer, the feasibility impact extensive molecular profiling applied to newly biopsied tumor sample targeted NGS (t-NGS) largest panel date whole-genome array-comparative genomic hybridization (aCGH) assessment single-gene alterations clinically relevant...
The targeting of cancer stem cells (CSCs) has proven to be an effective approach for limiting tumor progression, thus necessitating the identification new drugs with anti-CSC activity. Through a high-throughput drug repositioning screen, we identify antibiotic Nifuroxazide (NIF) as potent compound. Utilizing click chemistry strategy, demonstrate that NIF is prodrug specifically bioactivated in breast CSCs. Mechanistically, NIF-induced CSC death result synergistic action combines generation...
// Anthony Gonçalves 1, 2, * , François Bertucci 3, Arnaud Guille 3 Severine Garnier José Adelaide Nadine Carbuccia Oliver Cabaud Pascal Finetti Serge Brunelle 4 Gilles Piana Jeanne Tomassin-Piana 5 Maria Paciencia Eric Lambaudie 6 Cornel Popovici 7 Renaud Sabatier Carole Tarpin 1 Magali Provansal Jean-Marc Extra Eisinger Hagay Sobol Patrice Viens 2 Marc Lopez Christophe Ginestier Emmanuelle Charafe-Jauffret Max Chaffanet # Daniel Birnbaum Department of Medical Oncology, Institut...
Several genes, most of them unknown, the short arm chromosome 8 are involved in malignant diseases. Numerous studies have implicated a portion 8p11-p21 region as location one or more tumor suppressor genes variety human cancers, including breast cancer. We and others reported linkage analyses suggesting presence putative cancer susceptibility gene. Furthermore, several oncogenes 8p11-p12 reciprocal translocations myeloproliferative myelodysplastic disorders amplification To facilitate...
Abstract The 8p11–21 region is a frequent target of alterations in breast cancer and other carcinomas. We surveyed 34 tumor cell lines 9 pancreatic for this by use multicolor fluorescence situ hybridization (M‐FISH) BAC‐specific FISH. describe recurrent chromosome translocation breakpoint that targets the NRG1 gene on 8p12. encodes growth factors neuregulin/heregulin‐1 family are ligands tyrosine kinase receptors ERBB family. Breakpoints within were found four lines: ZR‐75‐1, dic(8;11);...
Langerhans cell histiocytosis (LCH) has a mostly favorable outcome, whereas sarcoma (LCS) is an aggressive tumor. It still unclear whether any specific molecular alterations could underlie the behavior of proliferations. We used targeted next-generation sequencing and array-comparative genomic hybridization to profile 22 LCH samples from different patients together with 3 LCS corresponding relapses same patient. The third relapse was composite tumor including both B-cell chronic lymphocytic...
Homeobox genes encode important developmental control proteins. In vertebrates, those encoding the proteins of HOX class and their most closely related families, including paraHOX metaHOX classes, are clustered in paralogous regions (or paralogons). We show that majority other homeobox (we called contra ) can also be belong to paralogons humans. This suggests they duplicated during vertebrate evolution along same processes as genes. tentatively assembled several superparalogons. One...
High-resolution array comparative genomic hybridization (a-CGH) enables the detection of intragenic rearrangements, such as single exon deletion or duplication. This approach can lead to identification new disease genes. We report on analysis 54 male patients presenting with intellectual deficiency (ID) and a family history suggesting X-linked (XL) inheritance maternal skewed X-chromosome inactivation (XCI), using home-made X-chromosome-specific microarray covering whole human at high...
Transmembrane receptors with tyrosine kinase activity (RTK) constitute a superfamily of proteins present in all metazoans that is associated the control and regulation cellular processes. They have been focus numerous studies are good subject for comparative analyses multigene families different species aimed at understanding metazoan evolution. The sequence genome nematode worm Caenorhabditis elegans available. This offers opportunity to study RTKs its entirety compare it mammalian...
Abstract During the last few years, an increasing number of microdeletion/microduplication syndromes have been delineated. This rapid evolution is mainly due to availability microarray technology as a routine diagnostic tool. Microdeletions 21q22.11q22.12 region encompassing RUNX1 gene reported in nine patients presenting with syndromic thrombocytopenia and mental retardation. responsible for autosomal dominant platelet disorder predisposition acute myelogenous leukemia. We report on three...