A5051980875- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Neurological diseases and metabolism
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- ATP Synthase and ATPases Research
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Hematopoietic Stem Cell Transplantation
- Peroxisome Proliferator-Activated Receptors
- Reproductive System and Pregnancy
- CRISPR and Genetic Engineering
- Genomics, phytochemicals, and oxidative stress
- Synthesis and biological activity
- Urinary and Genital Oncology Studies
- Autophagy in Disease and Therapy
- Barrier Structure and Function Studies
- Caveolin-1 and cellular processes
- Pluripotent Stem Cells Research
- Porphyrin Metabolism and Disorders
- Neutropenia and Cancer Infections
- Cancer Cells and Metastasis
- Leptospirosis research and findings
- Wnt/β-catenin signaling in development and cancer
Aix-Marseille Université
2016-2024
Centre National de la Recherche Scientifique
2006-2024
Inserm
2004-2024
Centre d’Immunologie de Marseille-Luminy
2004-2016
Centre de Recherche en Cancérologie de Marseille
2007-2014
Institut Paoli-Calmettes
2007-2014
Institut Pprime
2007-2014
Genetic programming for self-renewal Instead of repopulating themselves from tissue-resident stem cell pools like most types differentiated cells, tissue macrophages maintain by self-renewing. The underlying genetic programs that allow this, however, are unknown. Soucie et al. now report in at homeostasis, a pair transcription factors (MafB and c-Maf) bind to repress the enhancers genes regulating self-renewal. When need replenish their stocks, example response injury, they transiently...
Breast cancer is a complex and heterogeneous disease at the molecular level. Evolution difficult to predict according classical histoclinical prognostic factors. Different studies highlight importance of large-scale expression analyses improve taxonomy breast classification. Identification new markers that refine this patient management priority in field research.Nectins are cell adhesion molecules involved regulation epithelial physiology. We present here Nectin-4/PVRL4 as histological...
Vanin-1 is an epithelial ectoenzyme with pantetheinase activity and generating the amino-thiol cysteamine through metabolism of pantothenic acid (vitamin B(5)). Here we show that Vanin-1(-/-) mice, which lack in tissues, exhibit resistance to oxidative injury induced by whole-body gamma-irradiation or paraquat. This protection correlated reduced apoptosis inflammation reversed treating mutant animals cystamine. The better tolerance mice associated enhanced gamma-glutamylcysteine synthetase...
Colitis involves immune cell-mediated tissue injuries, but the contribution of epithelial cells remains largely unclear. Vanin-1 is an ectoenzyme with a pantetheinase activity that provides cysteamine/cystamine to tissue. Using 2,4,6-trinitrobenzene sulfonic acid (TNBS)-colitis model we show here deficiency protects from colitis. This protection reversible by administration cystamine or bisphenol A diglycidyl ether, peroxisome proliferator-activated receptor (PPAR)gamma antagonist. We...
Myeloablative treatment preceding hematopoietic stem cell (HSC) and progenitor (HS/PC) transplantation results in severe myeloid cytopenia susceptibility to infections the lag period before recovery. We have previously shown that macrophage colony-stimulating factor (CSF-1; M-CSF) directly instructed commitment HSCs. In this study, we tested whether effect had therapeutic benefit improving protection against pathogens after HS/PC transplantation. M-CSF resulted an increased production of...
Q fever is caused by Coxiella burnetii, a bacterium that survives in MPhi. Vanin-1 membrane-anchored pantetheinase controls tissue inflammation. Consequently, Vanin-1-deficient mice represent unique mouse model which stress-induced inflammation limited the reaction of resident cells. To investigate contribution host tissues control bacterial infection, we infected with C. burnetii. Mortality and morbidity were not affected. The lack had no effect on burnetii clearance but decreased formation...
Abstract One of the earliest events in epithelial carcinogenesis is dissolution tight junctions and cell polarity signals that are essential for normal barrier function. Here, we report EFA6B, a guanine nucleotide exchange factor Ras superfamily protein Arf6 helps assemble stabilize junction, required to maintain apico-basal mesenchymal phenotypes mammary cells. In organotypic three-dimensional cultures, endogenous levels EFA6B were critical determine epithelial–mesenchymal status....
Background Targeted therapies, associated with standard chemotherapies, have improved breast cancer care. However, primary and acquired resistances are frequently observed the development of new concepts is needed. High-throughput approaches to identify active safe molecules or without an "a priori" currently developed. Also, repositioning already-approved drugs in therapy growing interest. The thiomorpholine hydroxamate compound TMI-1 has been previously designed inhibit metalloproteinase...
<p>Supplementary Data. Unedited Full images of immunoblots The figure contains all the unedited presented in manuscript</p>
<p>Supplementary Figures. Fig.S1: Additional confocal images showing that expression of EFA6Bvsvg in MCF7 cells restores normal apico-basal polarity and promotes lumen formation Fig.S2: Analysis the specificity EFA6B repression using siRNAs Fig.S3: abrogates assembly TJ leads to unorganized aggregates Fig.S4: Exogenous TGFβ-induced EMT MDCK Fig.S5: EFA6B/PSD4 mutations copy number alterations from cBioPortal website</p>
<p>Supplementary Methods</p>
<p>Supplementary Table. Description of the datasets used for EFA6B/PSD4 mRNA expression analysis in breast cancer samples</p>
<p>Supplementary Data. Unedited Full images of immunoblots The figure contains all the unedited presented in manuscript</p>
<p>Supplementary Figures. Fig.S1: Additional confocal images showing that expression of EFA6Bvsvg in MCF7 cells restores normal apico-basal polarity and promotes lumen formation Fig.S2: Analysis the specificity EFA6B repression using siRNAs Fig.S3: abrogates assembly TJ leads to unorganized aggregates Fig.S4: Exogenous TGFβ-induced EMT MDCK Fig.S5: EFA6B/PSD4 mutations copy number alterations from cBioPortal website</p>
<p>Supplementary Table. Description of the datasets used for EFA6B/PSD4 mRNA expression analysis in breast cancer samples</p>
<p>Supplementary Methods</p>
<div>Abstract<p>One of the earliest events in epithelial carcinogenesis is dissolution tight junctions and cell polarity signals that are essential for normal barrier function. Here, we report EFA6B, a guanine nucleotide exchange factor Ras superfamily protein Arf6 helps assemble stabilize junction, required to maintain apico-basal mesenchymal phenotypes mammary cells. In organotypic three-dimensional cultures, endogenous levels EFA6B were critical determine...
<div>Abstract<p>One of the earliest events in epithelial carcinogenesis is dissolution tight junctions and cell polarity signals that are essential for normal barrier function. Here, we report EFA6B, a guanine nucleotide exchange factor Ras superfamily protein Arf6 helps assemble stabilize junction, required to maintain apico-basal mesenchymal phenotypes mammary cells. In organotypic three-dimensional cultures, endogenous levels EFA6B were critical determine...