A study was conducted to determine the presence of resveratrol, pterostilbene, and piceatannol in Vaccinium berries. Samples representing selections cultivars 10 species from Mississippi, North Carolina, Oregon, Canada were analyzed by gas chromatography/mass spectrometry. Resveratrol found angustifolium (lowbush blueberry), arboretum (sparkleberry), ashei (rabbiteye corymbosum (highbush elliottii (Elliott's macrocarpon (cranberry), myrtillus (bilberry), stamineum (deerberry), vitis-ideae...

Abstract The present study evaluated the preclinical pharmacokinetics and pharmacodynamics of trans ‐pterostilbene, a constituent some plants. Right jugular vein cannulated male Sprague‐Dawley rats were dosed i.v. with 20 mg/kg pterostilbene samples analysed by reverse phase HPLC method. Serum AUC, serum t 1/2 , urine Cl total Vd β 17.5 ± 6.6 µg/h/mL, 1.73 0.78 h, 17.3 5.6 0.960 0.025 L/h/kg 2.41 1.13 L/kg (mean SEM), respectively. A glucuronidated metabolite was detected in both urine....

Pterostilbene, a natural methoxylated analogue of resveratrol, was evaluated for antioxidative potential. The peroxyl-radical scavenging activity pterostilbene the same as that having total reactive antioxidant potentials 237 ± 58 and 253 53 μM, respectively. Both compounds were found to be more effective than Trolox free radical scavengers. Using plant system, also shown resveratrol in inhibiting electrolyte leakage caused by herbicide-induced oxidative damage, both had α-tocopherol....

Natural products represent a vast repository of materials and compounds with evolved biological activity, including phytotoxicity. Some these can be used directly or as templates for herbicides. The molecular target sites are often unique. Strategies the discovery outlined. Numerous examples individual phytotoxins crude preparations weed management potential provided. An example research to find natural product solution unique pest problem (blue-green algae in aquaculture) is described....

Glyphosate-resistant (GR) soybean [Glycine max (L.) Merr.] was developed by stable integration of a foreign gene that codes insensitive enzyme 5-enolpyruvylshikimate-3-phosphate synthase, an in the shikimate pathway, target pathway glyphosate. Application glyphosate to GR results injury under certain conditions. It hypothesized if is completely resistant glyphosate, could be caused metabolite aminomethylphosphonic acid (AMPA), known phytotoxin. Glyphosate and AMPA effects on one-...

The estrogenic isoflavones of soybeans and their glycosides are products the shikimate pathway, target pathway glyphosate. This study tested hypothesis that nonphytotoxic levels glyphosate other herbicides known to affect phenolic compound biosynthesis might influence these nutraceutical compounds in glyphosate-resistant soybeans. effects were determined on from identical experiments conducted different cultivars Mississippi Missouri. Four commonly used herbicide treatments compared a...

Age-related diseases of the brain compromise memory, learning, and movement are directly linked with increases in oxidative stress inflammation. Previous research has shown that supplementation berries can modulate signaling primary hippocampal neurons or BV-2 mouse microglial cells. Because their high polyphenolic content, fruit pulp fractions açai ( Euterpe oleracea Mart.) were explored for protective effect on Freeze-dried was fractionated using solvents different polarities analyzed HPLC...

Resveratrol, a stilbenoid antioxidant found in grapes, wine, peanuts and other berries, has been reported to have hypolipidemic properties. We investigated whether resveratrol its three analogues (pterostilbene, piceatannol, trimethyl ether) would activate the peroxisome proliferator-activated receptor α (PPARα) isoform. This nuclear is proposed mediate activity of lipid-lowering drugs such as fibrates. The four stilbenes were evaluated at 1, 10, 100, 300 μM along with ciprofibrate (positive...

Scutellaria is a traditional herbal remedy with potential anti-cancer activity. The purpose of this study was to evaluate anticancer mechanisms thirteen species and analyze their leaf, stem root extracts for levels common biologically active flavonoids: apigenin, baicalein, baicalin, chrysin, scutellarein, wogonin. Malignant glioma, breast carcinoma prostate cancer cells were used determine tumor-specific effects on cell proliferation, apoptosis cycle progression, via the MTT assay flow...

In recent years, not only has the role of miRNAs in cancer become increasingly clear but also their utilization as potential biomarkers and therapeutic targets gained ground. Although importance dietary stilbenes such resveratrol pterostilbene anti-cancer agents is well recognized, our understanding miRNA-targeting capabilities still limited. previous study, we reported that downregulates PTEN-targeting members oncogenic miR-17 family, which are overexpressed prostate cancer. This study...

Abstract Oxidative/nitrosative stress and generation of proinflammatory cytokines are hallmarks inflammation. Because chronic inflammation is implicated in several pathologic conditions humans, including cancers the colon, anti-inflammatory compounds may be useful chemopreventive agents against colon cancer. Stilbenes, such as resveratrol, have diverse pharmacologic activities, which include anti-inflammation, cancer prevention, a cholesterol-lowering effect, enhanced insulin sensitivity,...

Nutritional interventions based on the use of natural bioactive compounds might offer new possibilities for reshaping obesity-associated bacterial dysregulation or dysbiosis and improving health. We evaluated whether pterostilbene supplementation could induce changes in gut microbiota composition these modifications were associated with improvements metabolic variables.Zucker (fa/fa) rats given a standard diet supplemented (n = 10) not 9) (15 mg/kg body weight/day) by oral gavage 6 weeks....

A bioactivity‐guided isolation method was developed with the objective of isolating allelochemicals in rice ( Oryza sativa L.). Roots allelopathic cultivar Taichung Native 1, grown hydroponically, were extracted and fractionated, activity fractions followed using a 24‐well culture plate microbioassay. Some obtained consisted pure compounds, but none inhibited growth barnyardgrass [ Echinochloa crusgalli (L.) Beauv.] at lower concentration which they tested. Identified compounds azelaic acid;...

Abstract Purpose: Epidemiologic studies have linked the consumption of fruits and vegetables to reduced risk several types cancer. Laboratory animal model provided evidence that stilbenes, phenolic compounds present in grapes blueberries, play a role inhibiting certain cancers. Pterostilbene, naturally occurring stilbene from was tested for its preventive activity against colon carcinogenesis. Experimental Design: Experiments were designed study inhibitory effect pterostilbene formation...

Research suggests that polyphenolic compounds contained in fruits and vegetables are rich color may have potent antioxidant anti-inflammatory activities. The present studies determined if stilbene (e.g., resveratrol) would be efficacious reversing the deleterious effects of aging 19 month old Fischer 344 rats. Experiment I utilized resveratrol six analogues examined their efficacies preventing dopamine-induced decrements calcium clearance following oxotremorine-induced depolarization COS-7...

Stilbenes are phytochemicals present in grapes, berries, peanuts and red wine.A widely studied stilbene, resveratrol (trans-3,5,4#trihydroxystilbene), has been shown to exert antioxidant, antiinflammatory, chemopreventive antiaging effects a number of biological systems.We reported earlier that pterostilbene (trans-3,5-dimethoxy-4#-hydroxystilbene), structurally related stilbene found blueberries, was effective reducing the incidence multiplicity aberrant crypt foci formation colon rats...

Aminomethylphosphonic acid (AMPA) is the most frequently detected metabolite of glyphosate in plants. The objective this study was to determine if there any correlation metabolism AMPA different plant species and their natural level resistance glyphosate. Greenhouse studies were conducted I50 values (rate required cause a 50% reduction growth) quantify shikimate concentrations selected leguminous nonleguminous treated with at respective rates. Coffee senna [Cassia occidentalis (L.) Link]...

Abstract Stilbenes are phytoalexins that become activated when plants stressed. These compounds exist in foods and widely consumed. Resveratrol is a grape‐derived stilbene, which possesses wide range of health‐promoting activities, including anticancer properties. Several other stilbenes structurally similar to resveratrol also available food, but their biological activities remain largely unknown. In this study, we compared the effects its natural derivatives pterostilbene, trans...