A5015826386- Adipose Tissue and Metabolism
- Sirtuins and Resveratrol in Medicine
- Liver Disease Diagnosis and Treatment
- Biochemical effects in animals
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Phytochemicals and Antioxidant Activities
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and biosynthesis
- Autophagy in Disease and Therapy
- Problem and Project Based Learning
- Polysaccharides Composition and Applications
- Tea Polyphenols and Effects
- Adipokines, Inflammation, and Metabolic Diseases
- Gut microbiota and health
- Antioxidant Activity and Oxidative Stress
- Educational Robotics and Engineering
- Fungal Biology and Applications
- Liver Disease and Transplantation
- Moringa oleifera research and applications
- E-Learning and Knowledge Management
- Spectroscopy and Chemometric Analyses
- Cardiovascular Disease and Adiposity
- Postharvest Quality and Shelf Life Management
- Algal biology and biofuel production
University of the Basque Country
2014-2024
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2013-2024
Instituto de Salud Carlos III
2014-2024
BioCruces Health research Institute
2020-2024
Biogipuzkoa Health Research Institute
2014
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2014
Centro de Investigación Biomédica en Red
2014
Non-alcoholic fatty liver disease (NAFLD) is one of the most common manifestations chronic worldwide. The aim present study was to assess effect resveratrol on fat accumulation, as well activity those enzymes involved in lipogenesis and acid oxidation fa/fa Zucker rats. A total thirty rats were assigned three experimental groups orally treated with for 6 weeks, or without (C: control group; RSV15 group: 15 mg/kg body weight per d; RSV45 45 d). Liver histological analysis performed by...
Nutritional interventions based on the use of natural bioactive compounds might offer new possibilities for reshaping obesity-associated bacterial dysregulation or dysbiosis and improving health. We evaluated whether pterostilbene supplementation could induce changes in gut microbiota composition these modifications were associated with improvements metabolic variables.Zucker (fa/fa) rats given a standard diet supplemented (n = 10) not 9) (15 mg/kg body weight/day) by oral gavage 6 weeks....
The current study aimed to demonstrate the effects of pterostilbene in rats fed an obesogenic diet. For this purpose, was administered at doses 15 mg/kg body weight/day (PT15 group) or 30 (PT30 for 6 weeks. Pterostilbene reduced adipose tissue mass -15.1% (PT15) and -22.9% (PT30). In tissue, it decreased malic enzyme (-39.4 -49.5% PT15 PT30 groups, respectively) fatty acid synthase (-45 -53.4% PT30) activities. Acetyl-CoA carboxylase activity AMPK increased only group. liver, (PT30) (-29.5%)...
Proposed miRNA mechanisms of action resveratrol in triacylglycerol metabolism changes adipose tissue.
This study aims to determine whether pterostilbene improves glycaemic control in rats showing insulin resistance induced by an obesogenic diet. Rats were divided into 3 groups: the group and two groups treated with either 15 mg kg(-1) d(-1) (PT15) or 30 of (PT30). HOMA-IR was decreased both pterostilbene-treated groups, but this reduction greater PT15 (-45% -22% respectively vs. group). The improvement not due a delipidating effect on skeletal muscle. In contrast, GLUT4 protein expression...
The potential bioactivities for alleviating Metabolic Syndrome associated risk factors were evaluated in carob (Ceratonia siliqua L.) fruit by-products, i.e. seed peel, germ and pod. Carob peel showed higher phenolic content than pod (99.72, 80.24 47.06 μmol GAE g-1, respectively). Pod mostly contained gallic acid gallotannins; germ's as most abundant polyphenols quercetin apigenin derivatives. revealed stronger antioxidant capacities compared to germ. strongest antihypertensive activity was...
Different studies have revealed that oxidative stress and inflammation are crucial in NAFLD (Non-alcoholic fatty liver disease). The aim of this study is to analyze whether pterostilbene resveratrol able either avoid or delay the progression non-alcoholic steatosis towards steatohepatitis. This has been performed by examining their effects on stress, inflammation, fibrosis pre-carcinogenic stages. Rats were distributed into five experimental groups fed with a standard diet high-fat...
Studies conducted in mice have revealed positive effects of punicic acid (PUA). The aim this study was to analyze the PUA on fat accumulation and glycemic control rats fed an obesogenic diet. Rats were randomly divided into two groups: group (diet supplemented with 0.5% PUA). No changes observed adipose tissue weights. glucose tolerance test showed that value had decreased significantly at final time (120 min) (-19.3%), as fructosamine levels (-11.1%). However, homeostasis model assessment...
Phenolic compounds are among the most investigated herbal remedies, as is especially case for resveratrol. Many reports have shown its anti-aging properties and ability to reduce obesity diabetes induced by high-fat diet in mice. However, such beneficial effects hardly translate from animal models humans. The scientific community has therefore tested whether other plant phenolic may surpass of In this regard, it been reported that piceatannol reproduces rodents anti-obesity actions parent...