Obesity and type 2 diabetes are associated with increased lipogenesis in the liver. This results fat accumulation hepatocytes, a condition known as hepatic steatosis, which is form of nonalcoholic fatty liver disease (NAFLD), most common cause dysfunction United States. Carbohydrate-responsive element-binding protein (ChREBP), transcriptional activator glycolytic lipogenic genes, has emerged major player development steatosis mice. However, molecular mechanisms enhancing its activity remain...

Abstract Background A remarkable range of biological functions have been ascribed to resveratrol. Recently, this polyphenol has shown body fat lowering effects. The aim the present study was assess some potential underlying mechanisms action which take place in adipose tissue. Methods Sixteen male Sprague-Dawley rats were randomly divided into two groups: control and treated with 30 mg resveratrol/kg weight/d. All fed an obesogenic diet after six weeks treatment white tissues dissected....

MicroRNAs (miRNAs) are being increasingly studied in relation to energy metabolism and body composition homeostasis. Indeed, the quantitative analysis of miRNAs expression different adiposity conditions may contribute understand intimate mechanisms participating weight control find new biomarkers with diagnostic or prognostic value obesity management.The aim this study was search for blood cells whose could be used as loss.Ten Caucasian obese women were selected among participants a...

To analyze whether a combination of quercetin (Q) and resveratrol (RSV) would induce white adipose tissue (WAT) browning effect.Thirty-six rats were fed an obesogenic diet divided into four groups: control, treated with RSV (15 mg/kg body weight/day; group), Q (30 or both polyphenols (RSV + group).After 6 weeks, WAT weights significantly reduced in the group. In perirenal RSV, groups, unilocular adipocytes appeared majority cells, while group numerous multilocular positive immunostaining for...

Abstract Background Vitamin K has been related to glucose metabolism, insulin sensitivity and diabetes. Because inflammation underlies all these metabolic conditions, it is plausible that the potential role of vitamin in metabolism occurs through modulation cytokines molecules. The purpose study was assess associations between dietary intake peripheral adipokines other risk markers resistance type 2 diabetes mellitus. Methods Cross-sectional longitudinal assessments 510 elderly participants...

Scope . To determine whether doses of quercetin in the range serum concentrations exert any effect on triacylglycerol accumulation maturing preadipocytes and mature adipocytes. The influence expression adipogenic markers as well gene activity enzymes involved metabolism were assessed. Methods Results 3T3-L1 treated during differentiation adipocytes for 24 hours with low (0.1–10 µ M) quercetin. Triacylglycerol content both cell types free fatty acid glycerol incubation medium measured...

In mammals, the main component of circadian system is suprachiasmatic nucleus in hypothalamus. However, clocks are also present most peripheral tissues, such as adipose tissue. The aim study was to analyse potential effects resveratrol on changes induced by high-fat feeding expression clock genes and clock-controlled white tissue from rats. For this purpose, rats were divided into three groups: a control group, fed standard diet, two other groups, either diet supplemented with (RSV) or no...

Proposed miRNA mechanisms of action resveratrol in triacylglycerol metabolism changes adipose tissue.

Objective Scientific research is constantly striving to find molecules which are effective against excessive body fat and its associated complications. Taking into account the beneficial effects that resveratrol exerts on other pathologies through miRNA, aim of present work was analyze possible involvement miRNAs in regulation adipogenic transcription factors peroxisome proliferator-activated receptor γ (pparγ), CCAAT enhancer-binding proteins α β (cebpβ cebpα) induced by metabolites....

Apple pomace has been proposed as a quality enhancer for gluten-free bread, but its composition and physicochemical features differ significantly depending on the apple cultivar. The objective of this article was to characterize powder (APP) from certain varieties Basque Country study feasibility adding it focusing nutritional aspects. APP obtained by washing, drying grinding, added at 0, 5, 6 8%, together with other ingredients, such flours, corn starch whey protein. had reddish-grey...

The aim of the present study was to determine whether reduction in liver fat previously observed our laboratory a cohort rats which had been fed an obesogenic diet mediated by changes expression microRNA (miRNA)-103-3p, miRNA-107-3p and miRNA-122-5p, represent 70% total miRNAs liver, as well their target genes. three analysed reduced treated with resveratrol. A sterol-regulatory element binding protein 1 (SREBP1) increase carnitine palmitoyltransferase 1a (CPT1a) were resveratrol-treated...

The purpose of the present work was both to analyze composition Spanish celiac women and study food habits gluten-free diet these patients, in order determine whether they achieve a balanced healthy as well highlight nutritional qualitative and/or quantitative differences. 54 adult (34 ± 13 years) took part six-month study. Height, weight body were measured. An analysis energy consumption macronutrient distribution their carried out. Their fulfillment micronutrient intake recommendations...

The treatment of Celiac disease consists in a strict lifelong gluten-free (GF) diet. As the ingestion small amounts can have damaging complications, there has been an ongoing discussion regarding safe threshold for dietary residual gluten. aim was to analyze evolution gluten content cereal-based GF foodstuffs (n = 3141) from 1998 2016 measured by enzyme-linked immunosorbent assay (ELISA) technique. Eight categories were defined: flours, breakfast cereals/bars, bakery, pasta, breads, dough,...

Quercetin (Q) has rapid metabolism, which may make it worthwhile to focus on the potential activity of its metabolites. Our aim was evaluate triglyceride-lowering effects Q metabolites in mature and pre-adipocytes, compare them those induced by Q. 3T3-L1 pre-adipocytes were treated with 0.1, 1 10 µM Q, tamarixetin (TAM), isorhamnetin (ISO), quercetin-3-O-glucuronide (3G), quercetin-3-O-sulfate (3S), as well 3S quercetin-4-O-sulfate (4S) mixture (3S+4S). Triglyceride (TG) content both cell...

Studies conducted in mice have revealed positive effects of punicic acid (PUA). The aim this study was to analyze the PUA on fat accumulation and glycemic control rats fed an obesogenic diet. Rats were randomly divided into two groups: group (diet supplemented with 0.5% PUA). No changes observed adipose tissue weights. glucose tolerance test showed that value had decreased significantly at final time (120 min) (-19.3%), as fructosamine levels (-11.1%). However, homeostasis model assessment...