A5088055575- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Heart Rate Variability and Autonomic Control
- Circadian rhythm and melatonin
- Mental Health Research Topics
- Sleep and related disorders
- Health, Environment, Cognitive Aging
- Advanced Neuroimaging Techniques and Applications
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Child and Adolescent Psychosocial and Emotional Development
- Cancer-related cognitive impairment studies
- Genetics, Aging, and Longevity in Model Organisms
- Health and Lifestyle Studies
- Dietary Effects on Health
- High Altitude and Hypoxia
- Psychosomatic Disorders and Their Treatments
- Spaceflight effects on biology
- Personality Disorders and Psychopathology
- EEG and Brain-Computer Interfaces
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Health, psychology, and well-being
- Neuroendocrine regulation and behavior
- Schizophrenia research and treatment
Pontificia Universidad Católica Argentina
2017-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2016-2023
University of Buenos Aires
2018-2023
Instituto de Neurología Cognitiva
2020-2022
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia
2016-2021
Centro Científico Tecnológico - San Juan
2017-2020
Background:We have obtained previous evidence of limbic dysfunction in middle-aged, asymptomatic offspring late-onset Alzheimer's disease (LOAD) patients, and failure to recover from proactive semantic interference has been shown be a sensitive cognitive test other groups at risk for LOAD. Objective:To assess the effects specific deficits as they relate functional magnetic resonance imaging (fMRI) neocortical connectivity middle aged individuals with LOAD (O-LOAD) age-equivalent controls....
Abstract Background One common denominator to the clinical phenotypes of borderline personality disorder (BPD) and major depressive (MDD) is emotion regulation impairment. Although these two conditions have been extensively studied separately, it remains unclear whether their impairments are underpinned by shared or distinct neurobiological alterations. Methods We contrasted neural correlates negative across an adult sample BPD patients ( n = 19), MDD 20), healthy controls (HCs; 19). Emotion...
Early neuropathological changes characteristic of late-onset Alzheimer´s disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep-wake rhythm. Indeed, sleep pattern is an emerging biomarker a potential pathophysiological mechanism in LOAD. We hypothesized cognitively asymptomatic, middle-aged offspring patients with LOAD would display series circadian rhythm abnormalities prior to the onset objective cognitive alterations. tested 31...
Abstract Working in extreme environments requires a wide range of cognitive, psychological and social competences. Antarctica represents one the most challenging habitats to work due its aridity, extremely cold weather, isolated conditions. This study aimed assess mood variations coping strategies, as well their possible modulation by group dynamics crew at Belgrano II Argentine Antarctic Station throughout 1 year confinement. Thirteen members Army completed emotional, questionnaires...
Failure to recover from proactive semantic interference (frPSI) has been shown be more sensitive than traditional cognitive measures in different populations with preclinical Alzheimer's disease. The authors sought characterize the structural and amyloid vivo correlates of frPSI cognitively normal offspring patients late-onset disease (O-LOAD), compared individuals without a family history neurodegenerative disorders (CS). evaluated LASSI-L, test tapping other types delayed recall on RAVLT,...
Purpose: The objective of the present study was to assess sleep-wake differences autonomic activity in patients with mild cognitive impairment (MCI) compared control subjects. As a post-hoc objective, we sought evaluate mediating effect melatonin on this association. Patients and Methods: A total 22 MCI (13 under treatment) 12 subjects were included study. Sleep-wake periods identified by actigraphy 24hr-heart rate variability measures obtained activity. Results: did not show any significant...
Introduction: Eye movement patterns during reading are well defined and documented. Each eye ends up in a fixation point, which allows the brain to process incoming information program following saccade. In this work, we investigated whether alterations task might be already present middle-aged, cognitively normal offspring of late-onset Alzheimer’s disease (O-LOAD). Methods: 18 O-LOAD age-matched healthy individuals with no family history LOAD participated study. Participants were seated...
There is a need for early indicators of Alzheimer's Disease (AD). Beta amyloid and Tau deposition begin in limbic, philogenetically old areas the central nervous system years prior to appearance first clinical symptoms. We sought determine if persons at higher risk sporadic AD display limbic phentoypes disease. tested sample 17 children patients between 40 60 age. measured circadian variation body temperature, cardiac autonomic activity, daily motor sleep-wake cycle, mood status cognitive...
Semantic interference memory deficits are an early clinical biomarker of Alzheimer's Disease (AD), already present in different groups with preclinical AD, as measured the LASSI-L. We tested hypothesis that SMD will be a sample middle-aged, cognitively normal adults at least one parent sporadic AD (O-LOAD; n=17), who known to have heightened risk for disorder, comparison healthy subjects without any family history (HC; n=16). further predicted would associated O-LOAD disrupted sleep-wake...
Early neuropathological changes characteristic of late-onset Alzheimer's disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep-wake rhythm. Indeed, sleep pattern is an emerging biomarker a potential pathophysiological mechanism in LOAD. We hypothesized cognitively asymptomatic, middle-aged offspring patients with LOAD would display series circadian rhythm abnormalities prior to the onset objective cognitive alterations. tested 31...