A5016707085- Hydrocarbon exploration and reservoir analysis
- Toxic Organic Pollutants Impact
- Geology and Paleoclimatology Research
- Methane Hydrates and Related Phenomena
- Marine and coastal ecosystems
- Air Quality and Health Impacts
- Petroleum Processing and Analysis
- Antifungal resistance and susceptibility
- Atmospheric chemistry and aerosols
- Fungal Biology and Applications
- Environmental Toxicology and Ecotoxicology
- Atmospheric and Environmental Gas Dynamics
- Isotope Analysis in Ecology
- Multiple Myeloma Research and Treatments
- Oil Spill Detection and Mitigation
- Plant Surface Properties and Treatments
- Microbial Natural Products and Biosynthesis
- Groundwater and Isotope Geochemistry
- Coleoptera Taxonomy and Distribution
- Per- and polyfluoroalkyl substances research
- Microplastics and Plastic Pollution
- Effects and risks of endocrine disrupting chemicals
- Phytochemistry and Biological Activities
- Geological and Geophysical Studies Worldwide
- Fossil Insects in Amber
Institute of Environmental Assessment and Water Research
2011-2024
Josep Carreras Leukaemia Research Institute
2023-2024
Hospital de Sant Pau
2023-2024
Universitat Autònoma de Barcelona
2024
Centro de Implantología Cirugía Oral y Maxilofacial
2021-2023
Hospital Universitario Infanta Cristina
2016
Consejo Superior de Investigaciones Científicas
2007-2014
Instituto de Investigaciones Químicas y Ambientales de Barcelona
2006-2007
Institute of Advanced Chemistry of Catalonia
2004-2005
Hospital General Universitario Gregorio Marañón
2005
Aspergillus fumigatus is the most common airborne fungal pathogen for humans. In this mold, iron starvation induces production of siderophore triacetylfusarinine C (TAFC). Here we demonstrate a link between TAFC and ergosterol biosynthetic pathways, which are both critical virulence treatment infections. Consistent with mevalonate being limiting prerequisite biosynthesis, observed increased expression 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase (Hmg1) under starvation, reduced...
ABSTRACT Candida tropicalis ranks between third and fourth among species most commonly isolated from clinical specimens. Invasive candidiasis candidemia are treated with amphotericin B or echinocandins as first-line therapy, extended-spectrum triazoles acceptable alternatives. is usually susceptible to all antifungal agents, although several azole drug-resistant isolates being reported. However, C. resistant uncommon, only a few strains have reliably demonstrated high level of resistance...
The occurrence of amber in Sierra de Cantabria (álava, Basque Country) has been known for more than two decades but biological inclusions have only recently found. existence crustaceans (amphipods and isopods), chelicerates (acari arachnids), 12 orders insects, several bird feathers are reported this preliminary study. In addition, there leaf remains, molluscs, a fair number inorganic inclusions.Pollen analysis the clastic series indicates an age between upper Aptian—middle Albian, which...
The Middle East (ME) spans the transition between a temperate Mediterranean climate in Levant to hyper-arid sub-tropical deserts southern part of Arabian Peninsula (AP), with complex alpine topography northeast feeding Euphrates and Tigris rivers which support life Southeastern Fertile Crescent (FC). Climate projections predict severe drying several parts ME response global warming, making it important understand controls hydro-climate perturbations region. Here we discuss 23 speleothem...
A first case of temperature-dependent distribution polybromodiphenyl ethers (PBDEs) in remote areas is shown. Analysis these compounds fish from Pyrenean lakes distributed along an altitudinal transect shows higher concentrations at lower temperatures, as predicted the global distillation model. Conversely, no observed a similar Tatra mountains (Central Europe) nor high mountain throughout Europe. The polychlorobiphenyls (PCBs) examined for comparison showed significant temperature...
Abstract Essential oils from aerial parts of Thymus vulgaris have been obtained by hydrodistillation. Their components identified gas chromatography/mass spectrometry. Samples were collected in Catalonia (northeastern Iberian peninsula), specifically four locations along the Llobregat river basin. Such different altitudes with respect to sea level (1500 m; 700 300 100 m), and differences pluvial regime mean temperature. At m, samples a transplanted specimen 1500 order check influence change...
ABSTRACT Two erg3 genes encoding C-5 sterol desaturase enzymes (Erg3A and Erg3B) in Aspergillus fumigatus were characterized with respect to their nucleotide sequences null mutant phenotypes. Targeted disruption of the erg3A erg3B a double gene knockout, − , showed that they are not essential for A. viability. Mutant phenotypes clearly Erg3B is desaturase, but no apparent role Erg3A ergosterol biosynthesis was found. Susceptibility amphotericin B, itraconazole, fluconazole, voriconazole,...
The occurrence of amber in Sierra de Cantabria (álava, Basque Country) has been known for more than two decades but biological inclusions have only recently found. existence crustaceans (amphipods and isopods), chelicerates (acari arachnids), 12 orders insects, several bird feathers are reported this preliminary study. In addition, there leaf remains, molluscs, a fair number inorganic inclusions. Pollen analysis the clastic series indicates an age between upper Aptian—middle Albian, which...
Settling particles were collected by an array of sediment trap moorings deployed along the Cap de Creus (CCC) and Lacaze-Duthiers (LDC) submarine canyons on adjacent southern open slope (SOS) between October 2005 2006. This during common settling processes transferred to deep waters dense shelf water cascading (DSWC). Polychlorobiphenyls (PCBs), dichlorodiphenyltrichloroethane its metabolites (DDTs), chlorobenzenes (CBzs)--pentachlorobenzene hexachlorobenzene--and hexachlorocyclohexanes...
Halotolerant and halophilic melanized fungi were recently described in hypersaline waters. A close study of the sterol composition such fungi, namely Hortaea werneckii, Alternaria alternata, Cladosporium sphaerospermum, sp., Aureobasidium pullulans revealed dominance ergosterol presence 29 intermediates its biosynthesis pathway. The or absence from distinct synthesis routes gave insight into operative synthetic pathways 4,4,14-trimethylcholesta-8,24-dien-3β-ol (lanosterol) to Saccharomyces...
Abstract. Polybromodiphenyl ethers (PBDEs) were analyzed in bulk atmospheric deposition collected four European remote mountain areas over a period of two years (2004–2006): Lake Redon (Pyrenees, Catalonia, Spain), Gossenköllesee (Alps, Austria), Lochnagar (Grampian Mountains, Scotland) and Skalnate (Tatras, Slovakia). In all sites, the PBDE distributions dominated by BDE209. BDE47 BDE99 major low-brominated congeners, followed BDE100 BDE183. This composition is consistent with predominant...
Organic petrological and organic geochemical investigations have been carried out on Eocene lacustrine deposits from the Western Depression of Liaohe Basin (NE China). The purpose was to conduct a systematic organofacies classification these rocks, determine their source rock potential hydrocarbon characteristics, study depositional processes within this palaeo‐lake setting. Rock‐Eval data molecular biomarkers indicate that samples analysed were immature in terms thermal maturation. Three...
In this randomized phase II study (GEM-KyCyDex, clinicaltrials gov. Identifier: NCT03336073), the combination of weekly carfilzomib 70 mg/m2, cyclophosphamide and dexamethasone (KCd) was compared to (Kd) in relapsed/refractory multiple myeloma (RRMM) after 1-3 prior lines (PL). One hundred ninety-seven patients were included 1:1 receive KCd (97 patients) or Kd (100 28-day cycles until progressive disease unacceptable toxicity occurred. Patient median age years, number PL one (range, 1-3)....