A5066720367- Bone Metabolism and Diseases
- Genetic Associations and Epidemiology
- Bone health and osteoporosis research
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Fern and Epiphyte Biology
- Bone health and treatments
- Wnt/β-catenin signaling in development and cancer
- Plant Pathogens and Fungal Diseases
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- Digestive system and related health
- Microbial Community Ecology and Physiology
- Peroxisome Proliferator-Activated Receptors
- RNA Research and Splicing
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Gene expression and cancer classification
- Machine Learning in Bioinformatics
- Diabetes Treatment and Management
- FOXO transcription factor regulation
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Computational Drug Discovery Methods
University of Electronic Science and Technology of China
2024-2025
Heilongjiang Academy of Sciences
2014-2024
Central China Normal University
2013-2023
Bengbu Medical College
2022-2023
Community Link
2023
State Administration of Traditional Chinese Medicine of the People's Republic of China
2021
Jinan University
2021
Institute of Natural Resources
2020
Northeast Agricultural University
2014-2018
University of Hong Kong
2006-2011
Volcanic lava is an excellent model of primary succession, in which basalt-associated microorganisms drive the cycling different elements such as nitrogen, carbon, and other nutrients. Microbial communities volcanic soils are particular interest for study on emergence evolution life within special extreme conditions. The initial processes colonization subsequent rock weathering by microbial still poorly understood. We analyzed soil bacterial fungal diversities associated with (LBL) kipuka...
Genome-wide association studies (GWASs) have revealed many SNPs and genes associated with osteoporosis. However, influence of these on the predisposition to osteoporosis is not fully understood. We aimed identify GWASs-associated potentially influencing binding affinity transcription factors miRNAs, reveal enrichment signaling pathway "hub" GWAS-associated genes.We conducted multiple computational analyses explore function mechanisms genes, including SNP conservation analysis functional...
Objectives Genome-wide association studies (GWASs) have discovered associations of numerous SNPs and genes with obesity. However, the underlying molecular mechanisms through which these affect predisposition to obesity remain not fully understood. Aims our study are comprehensively characterize GWAS computational approaches. Methods For identified SNPs, functional annotation, effects on miRNAs binding impact protein phosphorylation were performed via RegulomeDB 3DSNP, miRNASNP, PhosSNP 1.0...
Abstract Background Some ferns have medicinal properties and are used in therapeutic interventions. However, the classification phylogenetic relationships of remain incompletely reported. Considering that chloroplast genomes provide ideal information for species identification evolution, this study, three unpublished one published were sequenced compared with other to obtain comprehensive on their evolution. Materials Methods The complete Dryopteris goeringiana (Kunze) Koidz, D....
Genome-wide association studies (GWASs) discovered a number of SNPs and genes associated with Alzheimer's disease (AD). However, how these influence the liability to AD is not fully understood. We deployed computational approaches explore function action mechanisms -related identified by GWASs, including effects 195 GWAS lead 338 proxy on miRNAs binding protein phosphorylation, their RegulomeDB 3DSNP scores, gene ontology, pathway enrichment protein-protein interaction network 126...
Dryopteris fragrans (D. fragrans) is a potential medicinal fern distributed in volcanic magmatic rock areas under tough environmental condition. Sporangia are important organs for reproduction. This study was designed to characterize the transcriptome characteristics of wild D. sporangia three stages (stage A, B, and C) with aim uncovering its molecular mechanism growth development. Using HiSeq 4000, 79.81 Gb clean data (each sample at least 7.95 GB) were obtained from nine samples, being...
Abstract The problem of the reliability ammunition storage environment is a hot topic in field modern military research, and key to find out main factors that affect sensitive components. Grey relational entropy analysis method can order influencing factors, but it can’t judge influence size correlation. Pearson analyze linear correlation better. Therefore, this paper proposes for complex problems such as environment, be used factors. Then grey other It lay foundation follow-up Through...
Bone mineral density (BMD) is one of the major determinants risk for osteoporotic fracture. Multiple studies reveal that peak bone mass under strong genetic influence. One susceptibility loci spine BMD has been mapped to chromosome 1q21-q23 in Caucasian population. We have previously replicated this finding Southern Chinese pedigrees and detected a maximum multipoint log odds (LOD) score 2.36 region. To further fine-map region, 380 single-nucleotide polymorphic (SNP) markers were genotyped...
Genome-wide association studies (GWAS) of type 2 diabetes (T2D) have discovered a number loci that contribute to susceptibility the disease. Future challenges include elucidation functional mechanisms through which these GWAS-identified modulate T2D disease risk. The aim present study was comprehensively characterize associated single nucleotide polymorphisms (SNPs) and genes computational approaches. Computational biology approaches used in included comparative genomic analyses annotation...
Abstract Dryopteris fragrans (L.) Schott is a fern growing on the surface of hot rocks and lava. It exposed to sunlight directly bears local environment. We sequenced complete nucleotide sequence its chloroplast (cp) genome. The cp genome was 151,978 bp in length, consisting large single-copy region (85,332 bp), small (31,947 bp) pair inverted repeats (17,314 bp). contained 112 genes 345 RNA editing sites protein-coding genes. Simple (SSRs) long repeat structure pairs (30–55 were identified....
MADS genes encode a family of transcription factors, some which control the identities floral organs in flowering plants. Most MADS-box fern have been cloned and analyzed model plants, such as Ceratopteris richardii pteridoides. In this study, new gene, DfMADS1(GU385475), was from Dryopteris fragrans (L.) Schott to better understand role evolution organs. The full-length DfMADS1 cDNA 973 bp length with 75 5'-UTR 169 3'-UTR. protein predicted contain typical MIKC-type domain structure...
Colorectal cancer (CRC) is one of the world's most common and deadly cancers. According to GLOBOCAN2020's global incidence rate mortality estimates, CRC third main cause second leading cancer-related deaths worldwide. The US Food Drug Administration has approved auranofin for treatment rheumatoid arthritis. It a gold-containing chemical that inhibits thioredoxin reductase. Auranofin number biological activities, including anticancer activity, although it not been researched extensively in...