A5079619002- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Tracheal and airway disorders
- Coronary Artery Anomalies
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrhythmias and Treatments
- Autophagy in Disease and Therapy
- Aortic Disease and Treatment Approaches
- Cardiovascular Issues in Pregnancy
- Cardiac and Coronary Surgery Techniques
- Vascular anomalies and interventions
- Adipokines, Inflammation, and Metabolic Diseases
- Kawasaki Disease and Coronary Complications
- Cardiovascular and Diving-Related Complications
- Bacterial Genetics and Biotechnology
- Advanced Glycation End Products research
- Mechanical Circulatory Support Devices
- Cardiovascular Function and Risk Factors
- Endoplasmic Reticulum Stress and Disease
- RNA and protein synthesis mechanisms
- Vasculitis and related conditions
- Adipose Tissue and Metabolism
- Advanced Biosensing Techniques and Applications
Osaka University
2016-2024
National Cerebral and Cardiovascular Center
2019-2024
Hiratsuka Kyosai Hospital
2024
Kansai University
2020-2021
Shizuoka Children's Hospital
2014-2019
Hyogo Prefectural Amagasaki General Medical Center
2012-2015
University of Bologna
2015
University of Hyogo
2013-2014
Cardiovascular Research Center
2012
University of Pennsylvania
2010
ABSTRACT Autophagy is an intracellular degradation pathway conserved in eukaryotes. Among core autophagy-related (Atg) proteins, mammalian Atg9A the sole multi-spanning transmembrane protein, and both of its N- C-terminal domains are exposed to cytoplasm. It known that travels through trans-Golgi network (TGN) endosomal system under nutrient-rich conditions, transiently localizes autophagosome upon autophagy induction. However, significance trafficking for formation remains elusive. Here, we...
Abstract Autophagy is a highly conserved process from yeast to mammals in which intracellular materials are engulfed by double-membrane organelle called autophagosome and degrading fusing with the lysosome. The of autophagy regulated sequential recruitment function autophagy-related (Atg) proteins. Genetic hierarchical analyses show that ULK1 complex comprised ULK1-FIP200-ATG13-ATG101 translocating cytosol formation sites as most upstream ATG factor; this translocation critical initiation....
Several companies offer direct-to-consumer (DTC) genetic testing to evaluate ancestry and wellness. Massive-scale of thousands single-nucleotide polymorphisms (SNPs) is not error free, such errors could translate into misclassification risk produce a false sense security or unnecessary anxiety in an individual. We evaluated 3 DTC services genomics service that are based on DNA microarray solution genotyping with hydrolysis probes (TaqMan® analysis) compared the test results obtained for same...
In the present work we numerically simulated electrogenerated chemiluminescence (ECL) from a Ru(bpy)32+-doped silica nanoparticle (Ru-DSNP) in buffer containing tripropylamine (TPrA). An experimental study reported Zanarini et al. showed that ECL intensity for Ru-DSNP/TPrA system exhibits two emission waves, while potential of working electrode is swept positive direction. The first wave with peak at ∼0.9 V (vs Ag|AgCl) triggered by TPrA oxidation and governed deprotonation equilibrium...
OBJECTIVE—Adiponectin is an adipocyte-derived protein that acts to reduce insulin resistance in the liver and muscle also inhibits atherosclerosis. Although adiponectin reportedly enhances AMP-activated kinase tumor necrosis factor-α action downstream from signal, precise physiological mechanisms by which on skeletal muscles remain unknown. RESEARCH DESIGN AND METHODS—We treated murine primary cells with recombinant full-length human for 12 h searched, using two-dimensional electrophoresis,...
The bilaterally unbalanced development of pulmonary arteries (PAs), as a result unilateral arterial hypoplasia (PAhypo) makes patients either ineligible for the Fontan operation or candidates one-lung operation. In present study, we examined efficacy intrapulmonary-artery septation (IPAS), technique reported in 2007 which is constructed within central PA, with PAhypo.Sixteen PAhypo and an affected PA index ≤60 mm(2)/m(2), including non-confluent (NCPA), underwent IPAS between January 2000...
To review long-term outcomes of patients with right atrial (RA) isomerism who underwent common atrioventricular valve (CAVV) plasty.We retrospectively analysed 59 RA operated on between January 2004 and April 2016. We divided into those CAVV plasty (CAVV (+), 29 patients) without (-), 30), we compared the outcome groups. further before bidirectional cavopulmonary shunt (BCPS) operation (group BCPS, 13 or after BCPS 16), these reviewed 7 neonatal plasty.Kaplan-Meier estimated survival rates...
The aim of this study was to assess outcomes the deferred Norwood strategy, i.e. planned following routine bilateral pulmonary artery banding and ductal stenting or continuous prostaglandin E1 administration.Forty-five patients with hypoplastic left heart syndrome its variants treated strategy between 2012 2021 were enrolled. Mid-term retrospectively reviewed. median follow-up period after in hospital survivors 4.6 years (interquartile range: 1.9, 6.8).Fourteen (31.1%) had no risk factors....
Kampo, a system of traditional Japanese therapy utilizing mixtures herbal medicine, is widely accepted in the medical system. Kampo originated from Chinese and was gradually adopted into style. Although its effects on variety diseases are appreciated, underlying mechanisms remain mostly unclear. Using quantitative tf-LC3 system, we conducted high-throughput screen 128 kinds to evaluate autophagy. The results revealed suppressive effect Shigyakusan/TJ-35 autophagic activity. TJ-35...
Abstract OBJECTIVES The goal of this study was to determine the long-term surgical outcomes patients with functional single ventricles associated heterotaxy syndrome, risk factors for mortality and Fontan stage completion. METHODS Overall, 279 a ventricle syndrome who underwent an initial procedure at our institute between 1978 2021 were grouped into 4 “eras” based on year during which performed: era 1 (1978–1989, n = 71), 2 (1990–1999, 98), 3 (2000–2009, 64) (2010–2021, 46). Neonatal...
Many polypeptide chains are translocated across and integrated into the endoplasmic reticulum membrane through protein-conducting channels. During process, amino acid sequences of translocating scanned by channels classified to be retained in or lumen. We established an experimental system with which kinetic effect each residue on chain movement can analyzed a time resolution tens seconds. Positive charges greatly slow movement; only two lysine residues caused remarkable down, their effects...
Abstract OBJECTIVES The aim of this study was to identify the long-term therapeutic effect total cavopulmonary connection (TCPC) conversion with an extracardiac conduit. METHODS Between 1991 and 2014, 36 patients underwent TCPC Half these were diagnosed tricuspid atresia or its variant. left ventricle dominant in 26 (72.2%). Median age at interval from initial Fontan operation 24.1 years (interquartile range 18.9–29.2) 17.8 (15.4–20.9), respectively. Surgical cryoablation concomitantly...
The study objectives were to reconfirm the superiority of pulmonary valve-sparing procedure versus transannular patch for repair tetralogy Fallot and evaluate influence a right ventriculotomy in procedure.Between 1978 2003, 440 patients (aged <10 years) underwent repair. Of these patients, 242 (55.0%) procedure, 106 (24.1%) without ventriculotomy, 92 (20.9%) with ventriculotomy. End points focused on adverse events included all-cause mortality, reoperation, catheter intervention, symptomatic...
Abstract OBJECTIVES Our goal was to assess the efficacy of managing pulmonary blood flow from Norwood procedure with a right ventricle-to-pulmonary artery (RV–PA) conduit until stage 2 palliation (S2P). METHODS Among 48 consecutive patients undergoing between 2008 and 2018, 40 (83.3%) who survived discharge were included in this study. The primary diagnosis hypoplastic left heart syndrome 28 (70%) variant 12 (30%) patients. All received bilateral banding. median age weight at time 41...
A 35-month-old boy with severe truncal valve regurgitation underwent successful repair by tricuspidization using raphe slicing and an extension technique glutaraldehyde-treated autologous pericardium. His improved from to mild 5 years postoperatively. Tricuspidization pericardium might be one of the alternatives for a quadricuspid valve.
Abstract OBJECTIVES The aim of this study was to reveal the serial changes in tricuspid regurgitation (TR) after anatomic repair for congenitally corrected transposition great arteries. METHODS Between 1995 and 2018, 48 patients underwent (atrial/arterial switch 14 patients, atrial Rastelli 34 patients). mean age weight during 33 (interquartile range 21.8–62.1) months 12 (10.3–16.3) kg. preoperative TR less than mild 15 (31.3%), mild-to-moderate 29 (60.4%) more-than-moderate 4 (8.3%)....