A5064461615- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
- Birth, Development, and Health
- Pancreatic function and diabetes
- Diet and metabolism studies
- Biochemical effects in animals
- Neurotransmitter Receptor Influence on Behavior
- Regulation of Appetite and Obesity
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Diet, Metabolism, and Disease
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes and associated disorders
- Bioactive natural compounds
- Neuropeptides and Animal Physiology
- Anesthesia and Neurotoxicity Research
- Pharmacological Effects of Natural Compounds
- Saffron Plant Research Studies
- Pain Mechanisms and Treatments
- Tryptophan and brain disorders
- Prenatal Substance Exposure Effects
- Vitamin C and Antioxidants Research
- Muscle metabolism and nutrition
- Diabetes Management and Research
Shahid Beheshti University of Medical Sciences
2015-2024
Research Institute for Endocrine Sciences
2019-2021
Ahvaz Jundishapur University of Medical Sciences
2006
In the present study, effects of an ethanol and aqueous extract saffron Crocus sativus its constituents safranal crocin on stress‐induced reduction in food intake, weight gain anorexic time mice were investigated. Male albino (20–25 g) irregularly exposed to a trial electroshock stress for 7 days. Then, as well animal's intake recorded. addition, blood samples obtained days 1 corticosterone determination. Intraperitoneal (i.p.) administration but not (10, 50 100 mg/kg) significantly reduced...
The impact of anesthetic agents on endocrine and metabolic factors is an important issue. present study has compared the effects a short-term exposure to diethyl ether, isoflurane, or CO2 plasma corticosterone, insulin glucose concentrations since duration may have effect those factors. Male rats were divided into fed fasted groups. experimental briefly exposed (the degree anesthesia was identical), while control group not anesthetics. In rats, ether increased levels glucose. decreased...
This study explores the effects of maternal separation as a chronic early life stress (ELS) on pancreatic islets insulin content and secretion, their potential relationship with hippocampus spatial memory in young adulthood. Male rat offspring were divided into two groups: (STR) non-stress (non-STR) groups. The animals STR group separated from mothers during postnatal days (PND) 1 to 21. During weaning time, that is, PND-0 PND-21, body weight length pups measured. Blood samples collected...
Lavandula officinalis Chaix, Lamiaceae, extracts can inhibit inflammation and also pain induced by formalin in mice. This study evaluated the effects of L. hydro-alcoholic extract on cyclooxygenase (COX) type 1 2 activity To evaluate probable analgesic anti-inflammatory extract, flowers were prepared maceration extraction alcohol their studied male mice, using hot plate tests. The effect intraperitoneal (100, 200, 250, 300, 400 800 mg/kg), subcutaneous morphine (10 dexamethasone mg/kg; i.p.)...
The current study explored the impact of high fat diet (HFD) on hepatic oxidative and endoplasmic reticulum (ER) stress its insulin degrading enzyme (IDE) content with injection 4-phenyl butyric acid (4-PBA) in adult male rats.Following weaning period, offspring were distributed among six distinct groups. corresponding was used for 20 weeks, subsequently 4-PBA administered three consecutive days. Plasma glucose levels, HOMA-β (homeostasis model assessment β-cell), ER biomarkers IDE protein...
High-fat diets and chronic stress are prevalent risk factors for various diseases in modern societies.This study investigated the effect of high-fat diet on glucose-related metabolic responses to foot-shock stress.Male rats were divided into (containing 54.21% saturated 44.89% unsaturated fatty acids) normal groups then non-stress subgroups. The applied 5 weeks, was induced during last week course. Plasma levels parameters, HOMA-IR index, intra-abdominal fat weight, islets' insulin secretion...
This study investigated the effect of long-term high-fat diet (HFD) on plasma lipid profile and probability inflammation in adult rats. After weaning, male offspring were divided into six groups based type medication. 20 weeks dietary intake, 4-PBA (endoplasmic reticulum (ER) stress inhibitor) was injected for three days. Then, blood samples taken to measure concentrations low-density lipoprotein (LDL), triglyceride (TG), high-density (HDL), cholesterol, leptin interleukin 1-β (IL 1-β). The...
The effects of saffron ethanolic extract and its constituent, safranal, on the acquisition expression morphine-induced place preference (CPP) in male Swiss Webster mice (20-25 g) were investigated present study. An unbiased conditioning method was applied for assessment morphine reward properties. safranal administered intraperitoneally (i.p.) during (acquisition) or after induction (expression) CPP. In a pilot study, alone to animals assess if they have any Subcutaneous (s.c.) (4 8 mg...
Despite daily increase in diabetic patients the world, currently approved medications for this disease, at best, only reduce its progression speed. Using novel technologies is a solution synthetizing more efficient medicines. In present study, we evaluated anti-diabetic effects of DIBc, nano metal-organic framework, which synthetized based on nanochelating technology.High-fat diet and streptozotocin-induced rats were treated by DIBc or metformin 6 weeks.DIBc decreased plasma glucose,...