A5091548510- Cardiac Valve Diseases and Treatments
- Platelet Disorders and Treatments
- RNA Research and Splicing
- AI in cancer detection
- Autoimmune Bullous Skin Diseases
- Cardiac Imaging and Diagnostics
- RNA modifications and cancer
- Brain Tumor Detection and Classification
- Aortic Disease and Treatment Approaches
- Digital Imaging for Blood Diseases
- Sarcoma Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Blood transfusion and management
- Blood donation and transfusion practices
- Water Quality Monitoring Technologies
- Chronic Lymphocytic Leukemia Research
- BRCA gene mutations in cancer
- Blood groups and transfusion
- Cardiovascular Function and Risk Factors
- Cardiac, Anesthesia and Surgical Outcomes
- Renal Diseases and Glomerulopathies
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Hematological disorders and diagnostics
Cedars-Sinai Smidt Heart Institute
2024-2025
Cedars-Sinai Medical Center
2024-2025
The Ohio State University Wexner Medical Center
2024
Maulana Azad National Institute of Technology
2022-2024
Cancer Institute (WIA)
2021-2024
MIT World Peace University
2024
Rabin Medical Center
2024
University of Central Florida
2024
Philadelphia VA Medical Center
2022
Brigham and Women's Hospital
2016-2019
Across the globe, women suffer from breast cancer fatal disease. It is arising surprisingly due to a lack of awareness among them and inconvenient reach diagnostic systems. Many computer-aided systems have been developed for detection cancer. These quite lower performance, so more accurate diagnosis need time save life human beings. For large imbalanced image datasets, efficient learning network very important detect classify accurately. In this paper, graph based adaptive regularized deep...
ZBP1 (zipcode-binding protein 1) was originally discovered as a trans -acting factor for the “zipcode” in 3′ untranslated region (UTR) of β-actin mRNA that is important its localization and translational regulation. Subsequently, has been found to be multifunctional regulator RNA metabolism controls aspects localization, stability, translation many mRNAs. To reveal how recognizes targets, we biochemically characterized interaction between zipcode. The third fourth KH (hnRNP K homology)...
How RNA-binding proteins recognize specific sets of target mRNAs remains poorly understood because current approaches depend primarily on sequence information. In this study, we demonstrate that recognition messenger RNAs (mRNAs) by requires the correct spatial positioning these sequences. We characterized both cis -acting elements and restraints define mode RNA binding zipcode-binding protein 1 (ZBP1/IMP1/IGF2BP1) to β-actin zipcode. The third fourth KH (hnRNP K homology) domains ZBP1...
Lifetime treatment of aortic valve disease is a matter increasing debate. Although the risks second intervention are recognized, little attention has been given to challenges third. This study delves into clinical characteristics, indications, and outcomes patients undergoing 3 interventions. The THIRD (THree aortIc Reinterventions for Disease) registry retrospective multicenter, international who underwent third procedure on valve, either surgically or transcatheter-based. Patients 2...
The IGF2 mRNA-binding proteins (ZBP1/IMP1, IMP2, IMP3) are highly conserved post-transcriptional regulators of RNA stability, localization and translation. They play important roles in cell migration, neural development, metabolism cancer survival. knockout phenotypes individual IMP suggest that each family member regulates a unique pool RNAs, yet evidence an underlying mechanism for this is lacking. Here, we combine systematic evolution ligands by exponential enrichment (SELEX) NMR...
Immune thrombocytopenic purpura (ITP) is mediated by antiplatelet autoantibodies possibly involving CD40:CD40L co-stimulation. Two humanized anti-CD40L monoclonal antibodies, hu5c8 and IDEC-131, were evaluated in 46 patients with chronic refractory ITP. Fifteen treated 20 mg/kg of hu5c8: four (27%) had complete responses (CR) two (13%) partial (PR). Three responders to successfully retreated demonstrating its efficacy. Thirty-one subsequent 5-20 per infusion IDEC-131: five (16%) responded...
Abstract Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs BRCA1/2 were overall cancer high grade (Gleason 8+) using an international sample 65 171 male PSV carriers cancer, 3,388 2,880 without the 3′ region (c.7914+) significantly elevated compared reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25–2.52; P 0.001], as well Gleason 8+ (HR 3.11; CI, 1.63–5.95;...
This study investigated responses to retreatment with rituximab in chronic immune thrombocytopenic purpura (ITP) patients. Treatment ITP patients induces long-lasting approximately 30% of but even these may relapse. Twenty who had achieved a response and relapsed were retreated (375 mg/m(2)x 4); this data was analyzed retrospectively. Subsequently, 16 prospectively randomized receive cyclophosphamide, vincristine prednisone (R-CVP) or double dose (DDR). Retreatment standard demonstrated...
Ideally, thrombophilia testing should be tailored to the type of thrombotic event without influence anticoagulation therapy or acute phase effects which can give false positive results that may result in long term anticoagulation. However, is often performed routinely unselected patients. We analyzed all consecutive orders during months October and November 2009 at an academic teaching institution. Information was extracted from electronic medical records for following: indication, timing,...
Abstract Small randomized trials have not shown an overall survival ( OS ) difference among local treatment modalities for patients with extremity soft‐tissue sarcomas (E‐ STS but were underpowered . We examine the impact of on and sarcoma mortality SM using two national registries. The National Cancer Database NCDB Surveillance, Epidemiology, End Results SEER Program analyzed separately to identify stage II ‐ III , high‐grade E‐ diagnosed between 2004 2013 treated (1) amputation alone, (2)...
Abstract Breast cancer is a worldwide fatal disease that exists mostly among women. The deep learning technique has proven its effectiveness, but the performance of existing systems quite compromising. In this work, transfer system suggested for efficient breast classification from histopathology images. This based on novel multi‐level progressive feature aggregation (MPFA) and spatial domain approach. combination pretrained Resnet101 backbone network with MPFA implemented to extract more...
Objective: Paracetamol and ibuprofen are widely used for fever in children as monotherapy combined therapy. None of the treatments is proven clearly superior to others. Hence, study was planned compare efficacy paracetamol, paracetamol-ibuprofen combination treatment febrile children. Materials Methods: This an investigator blind, randomized, comparative, parallel clinical trial conducted 99 children, 6 months 12 years age, allocated three groups. First group received paracetamol 15 mg/kg,...
Breast cancer is a major public health issue that may be remedied with early identification and efficient organ therapy. The diagnosis prognosis of severe serious illnesses are likely to followed examined by biopsy the affected in order identify classify malignin cells or tissues. histopathology tissue one advancements modern medicine for breast cancer. Haematoxylin eosin staining slides used pathologists benign malignant clinical instances invasive A digital whole slide imaging (WSI)...
Breast cancer is a deadliest disease worldwide among the women. By some means early detection very important to overcome it by prognosing on time. Deep networks having promising performance for different signal and image processing applications, breast classification one of applications diagnose efficiently. transfer learning approaches are its kind using nowadays computational time increase as well. Sparse deep network such VGG19 ReasNet50 etc. giving low but these light weight can be...
Artificial intelligence (AI) is an efficient technique frequently used to tackle practical issues in various engineering and medical fields. Apart from different areas, water desalination essential surviving humans, animals, plants. It a crucial industry for sustainable planet, we cannot live without water. As result, engineers researchers are quite active this area. Recent studies based on Elsevier’s Scopus database demonstrate how automation using emerging technologies has enhanced the...